Dynamic functional reorganizations and relationship with working memory performance in healthy aging
Open accessAbstract
In recent years, several theories have been proposed in attempts to identify the neural mechanisms underlying successful cognitive aging. Old subjects show increased neural activity during the performance of tasks, mainly in prefrontal areas, which is interpreted as a compensatory mechanism linked to functional brain efficiency. Moreover, resting-state studies have concluded that elders show disconnection or disruption of large-scale functional networks. We used functional MRI during resting-state and a verbal n-back task with different levels of memory load in a cohort of young and old healthy adults to identify patterns of networks associated with working memory and brain default mode. We found that the disruption of resting-state networks in the elderly coexists with task-related overactivations of certain brain areas and with reorganizations within these functional networks. Moreover, elders who were able to activate additional areas and to recruit a more bilateral frontal pattern within the task-related network achieved successful performance on the task. We concluded that the balanced and plastic reorganization of brain networks underlies successful cognitive aging. This observation allows the integration of several theories that have been proposed to date regarding the aging brain.
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The 3-back task probes executive control, and its cerebral correlates involve the bilateral posterior parietal cortex, premotor cortex, dorsal cingulate/medial premotor cortex, dorsolateral prefrontal cortex and ventrolateral prefrontal cortex.
“The 3-back task probes executive control, and its cerebral correlates involve the bilateral posterior parietal cortex, premotor cortex, dorsal cingulate/medial premotor cortex, dorsolateral prefrontal cortex and ventrolateral prefrontal cortex [48].”
From Dawn simulation light impacts on different cognitive domains under sleep restriction (2015) · cites this paper as [48]
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References 46 · Cited by 54
Research works printed but not linked: 1
- Hedden T. Van Dijk K. R. Shire E. R. Sperling R. A. Johnosn K. A. Buckner R. L. (2012). Failure to modulate attentional control in white matter pathology. Cereb. Cortex. 22, 1038– 1051 10.1093/cercor/bhr172 21765181 PMC3328340 · DOI
- Authors
- Sala-Llonch, R., Arenaza-Urquijo, E. M., Valls-Pedret, C., Vidal-Piñeiro, D., Bargalló, N., Junqué, C., & Bartrés-Faz, D.
- Affiliations
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- ORCID
- Junqué, Carme
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 6
- Pages
- 152-152
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC3369258
- OpenAlex
- W2101793277
- Cited by
- 54
- References
- 46
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 2 · 2012: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cognitive aging, working memory, resting-state networks, default mode network, neural compensation, neuroplasticity, functional reorganization, memory load, older adults
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