Insular Dysfunction Reflects Altered Between-Network Connectivity and Severity of Negative Symptoms in Schizophrenia during Psychotic Remission

Manoliu, Andrei; Riedl, Valentin; Doll, Anselm; Bäuml, Josef Georg; Mühlau, Mark; Schwerthöffer, Dirk; Scherr, Martin; Zimmer, Claus; Förstl, Hans; Bäuml, Josef; Wohlschläger, Afra M.; Koch, Kathrin; Sorg, Christian

doi:10.3389/fnhum.2013.00216

Insular Dysfunction Reflects Altered Between-Network Connectivity and Severity of Negative Symptoms in Schizophrenia during Psychotic Remission

Schizophrenia is characterized by aberrant intrinsic functional connectivity (iFC) within and between intrinsic connectivity networks (ICNs), including the Default Mode- (DMN), Salience- (SN), and Central Executive Network (CEN). The anterior insula (AI) of the SN has been demonstrated to modulat…