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Cited by 29Pain Management and TreatmentTactile and Sensory InteractionsStroke Rehabilitation and Recovery

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Plasticity in the Visual System is Associated with Prosthesis Use in Phantom Limb Pain

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Preißler, Sandra, Dietrich, Caroline, Blume, Kathrin R., Hofmann, Gunther O., Miltner, Wolfgang H. R., Weiss, Thomas·2013·Frontiers in Human Neuroscience
DOI 10.3389/fnhum.2013.00311PMC PMC3690782
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Abstract

The experience of strong phantom limb pain (PLP) in arm amputees was previously shown to be associated with structural neural plasticity in parts of the cortex that belong to dorsal and ventral visual streams. It has been speculated that this plasticity results from the extensive use of a functional prosthesis which is associated with increased visual feedback to control the artificial hand. To test this hypothesis, we reanalyzed data of cortical volumes of 21 upper limb amputees and tested the association between the amount of use of the hand prosthesis and cortical volume plasticity. On the behavioral level, we found no relation between PLP and the amount of prosthesis use for the whole patient group. However, by subdividing the patient group into patients with strong PLP and those with low to medium PLP, stronger pain was significantly associated with less prosthesis use whereas the group with low PLP did not show such an association. Most plasticity of cortical volume was identified within the dorsal stream. The more the patients that suffered from strong PLP used their prosthesis, the smaller was the volume of their posterior parietal cortex. Our data indicate a relationship between prosthesis use and cortical plasticity of the visual stream. This plasticity might present a brain adaptation process to new movement and coordination patterns needed to guide an artificial hand.

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Metadata

Authors
Preißler, S., Dietrich, C., Blume, K. R., Hofmann, G. O., Miltner, W. H. R., & Weiss, T.
Affiliations
  • Friedrich Schiller University Jena (DE)
  • Jena University Hospital (DE)
Corresponding author
Preißler, Sandra
ORCID
Venue
Frontiers in Human Neuroscience
Publisher
Frontiers Media SA
Published
2013
Volume
7
Pages
311-311
ISSN
1662-5161 (ISSN-L)
DOI
10.3389/fnhum.2013.00311
PMC
PMC3690782
OpenAlex
W2126277682
Cited by
29
References
9
Citations by year
2025: 3 · 2024: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
FWCI
2.12
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Human Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Bundesministerium für Bildung und Forschung (16SV3697)
  • Deutsche Gesetzliche Unfallversicherung
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords
phantom limb pain, cortical plasticity, prosthesis use, upper limb amputation, dorsal stream, posterior parietal cortex, cortical volume, artificial hand, visual feedback, brain adaptation

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