Slowing down: age-related neurobiological predictors of processing speed
Open accessAbstract
Processing speed, or the rate at which tasks can be performed, is a robust predictor of age-related cognitive decline and an indicator of independence among older adults. This review examines evidence for neurobiological predictors of age-related changes in processing speed, which is guided in part by our source based morphometry findings that unique patterns of frontal and cerebellar gray matter predict age-related variation in processing speed. These results, together with the extant literature on morphological predictors of age-related changes in processing speed, suggest that specific neural systems undergo declines and as a result slow processing speed. Future studies of processing speed - dependent neural systems will be important for identifying the etiologies for processing speed change and the development of interventions that mitigate gradual age-related declines in cognitive functioning and enhance healthy cognitive aging.
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These cognitive changes typically manifest at ages younger than those at which plaque deposition typically begins.
“These changes typically manifest at ages younger than those at which plaque deposition typically begins.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [244]
Cognitive speed and multitasking abilities become less robust with advancing age.
“Cognitive speed and multitasking abilities, for example, become less robust with advancing age.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [244]
At least some elements of cognitive decline evolve throughout adulthood.
“Lastly, it is worth noting that at least some elements of cognitive decline evolve throughout adulthood [195, 242-245].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [244]
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References 141 · Cited by 162
- Authors
- Eckert, M. A.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Eckert, Mark A.
- ORCID
- Eckert, Mark A.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 5
- Pages
- 25-25
- ISSN
- 1662-453X (ISSN-L)
- 1662-4548
- PMC
- PMC3061488
- OpenAlex
- W2096482701
- Cited by
- 162
- References
- 141
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 4 · 2023: 7 · 2022: 15 · 2021: 11 · 2020: 11 · 2019: 21 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 10 · 2014: 6 · 2013: 12 · 2012: 12
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Deafness and Other Communication Disorders (P50DC000422)
- National Center for Research Resources (C06RR014516)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- processing speed, aging, age-related cognitive decline, gray matter, frontal cortex, cerebellum, source-based morphometry, neural systems, healthy cognitive aging, older adults
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