Lack of spatial segregation in the representation of pheromones and kairomones in the mouse medial amygdala
Open accessAbstract
The nervous system is organized to detect, internally represent and process sensory information to generate appropriate behaviors. Despite the crucial importance of odors that elicit instinctive behaviors, such as pheromones and kairomones, their neural representation remains little characterized in the mammalian brain. Here we used expression of the immediate early gene product c-Fos as a marker of neuronal activity to find that a wide range of pheromones and kairomones produces activation in the medial nucleus of the amygdala, a brain area anatomically connected with the olfactory sensory organs. We see that activity in this nucleus depends on vomeronasal organ input, and that distinct vomeronasal stimuli activate a dispersed ensemble of cells, without any apparent spatial segregation. This activity pattern does not reflect the chemical category of the stimuli, their valence or the induced behaviors. These findings will help build a complete understanding of how odor information is processed in the brain to generate instinctive behaviors.
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Fos induction following social interactions showed widely dispersed response patterns.
“Electrical recordings in the MeApd of anesthetized mice have revealed sex-dependent differences in the neural responses to social cues (Bergan et al., 2014), while Fos induction following social interactions showed widely dispersed response patterns (Carvalho et al., 2015; Choi et al., 2005).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Carvalho et al., 2015
Activation of MeA neurons is highly dependent on VNO-mediated detection of pheromones, confirming a primary role in sensory processing of VNO information.
“and the activation of MeA neurons is highly dependent on VNO-mediated detection of pheromones, confirming a primary role in sensory processing of VNO information (Carvalho et al., 2015).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Carvalho et al., 2015
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References 49 · Cited by 25
- Authors
- Carvalho, V. M. A., Nakahara, T. S., Cardozo, L. M., Souza, M. A. A., Camargo, A. P., Trintinalia, G. Z., Ferraz, E., & Papes, F.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-08-11
- Volume
- 9
- Pages
- 283-283
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4531233
- OpenAlex
- W1774188767
- Cited by
- 25
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 7 · 2018: 2 · 2017: 2 · 2016: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Sao Paulo Research Foundation - FAPESP (09/00473-0)
- PRP/Unicamp (72515, 10215, 34814)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- pheromones, kairomones, medial amygdala, vomeronasal organ, olfactory processing, odor representation, c-fos, neuronal activity, innate behavior, spatial segregation
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