Retinal prostheses: progress toward the next generation implants
Open accessAbstract
In the last decade, various clinical trials proved the capability of visual prostheses, in particular retinal implants, to restore a useful form of vision. These encouraging results promoted the emerging of several strategies for neuronal stimulation aiming at the restoration of sight. Besides the traditional approach based on electrical stimulation through metal electrodes in the different areas of the visual path (e.g., the visual cortex, the lateral geniculate nucleus, the optic nerve, and the retina), novel concepts for neuronal stimulation have been mostly exploited as building blocks of the next generation of retinal implants. This review is focused on critically discussing recent major advancements in the field of retinal stimulation with particular attention to the findings in the application of novel concepts and materials. Last, the major challenges in the field and their clinical implications will be outlined.
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Retinal prostheses can profit from the retinotopic organisation and early positioning in the visual pathway.
“Besides the ease of surgical accessibility, they can also profit from the retinotopic organisation and early positioning in the visual pathway [26,27].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [27]
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References 61 · Cited by 83
- Authors
- Ghezzi, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Ghezzi, Diego
- ORCID
- Ghezzi, Diego
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-08-20
- Volume
- 9
- Pages
- 290-290
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4542462
- OpenAlex
- W1796712256
- Cited by
- 83
- References
- 61
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 9
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- retinal prosthesis, retinal stimulation, electrical stimulation, neurostimulation, vision restoration, implant materials, clinical trials
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