The Impact of high-intensity interval training on brain derived neurotrophic factor in brain: a mini-review.
Open accessAbstract
The brain-derived neurotrophic factor (BDNF) is a protein mainly synthetized in the neurons. Early evidence showed that BDNF participates in cognitive processes as measured at the hippocampus. This neurotrophin is as a reliable marker of brain function; moreover, recent studies have demonstrated that BDNF participates in physiological processes such as glucose homeostasis and lipid metabolism. The BDNF has been also studied using the exercise paradigm to determine its response to different exercise modalities; therefore, BDNF is considered a new member of the exercise-related molecules. The high-intensity interval training (HIIT) is an exercise protocol characterized by low work volume performed at a high intensity (i.e., ≥ 80% of maximal heart rate -HRmax-). Recent evidence supports the contention that HIIT elicits higher fat oxidation in skeletal muscle than other forms of exercise. Similarly, HIIT is a good stimulus to increase maximal oxygen uptake (VO2max). Few studies have investigated the impact of HIIT on the BDNF response. The present work summarizes the effects of acute and long-term HIIT on BDNF.
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The exact molecular mechanisms of increased BDNF production in response to physical exercising are not fully understood.
“the exact molecular mechanisms of increased BDNF production in response to physical exercising are not fully understood (for review, see Jiménez-Maldonado et al., 2018)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Jiménez-Maldonado et al., 2018
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References 87 · Cited by 118
- Authors
- Jiménez-Maldonado, A., Rentería, I., García-Suárez, P. C., Moncada-Jiménez, J., & Freire-Royes, L. F.
- Affiliations
- Universidad Autónoma de Baja California (MX)
- ORCID
- Rentería, Iván
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-11-14
- Volume
- 12
- Pages
- 839-839
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC6246624
- OpenAlex
- W2901536671
- Cited by
- 118
- References
- 87
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 11 · 2023: 16 · 2022: 20 · 2021: 18 · 2020: 15 · 2019: 12
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- high-intensity interval training, brain-derived neurotrophic factor, physical activity, neurotrophins, hippocampus, cognitive function, glucose homeostasis, lipid metabolism, fat oxidation, VO2max
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