Novel graphene electrode for retinal implants: an in vivo biocompatibility study
Open accessAbstract
Evaluating biocompatibility is a core essential step to introducing a new material as a candidate for brain-machine interfaces. Foreign body reactions often result in glial scars that can impede the performance of the interface. Having a high conductivity and large electrochemical window, graphene is a candidate material for electrical stimulation with retinal prosthesis. In this study, non-functional devices consisting of chemical vapor deposition (CVD) graphene embedded onto polyimide/SU-8 substrates were fabricated for a biocompatibility study. The devices were implanted beneath the retina of blind P23H rats. Implants were monitored by optical coherence tomography (OCT) and eye fundus which indicated a high stability in vivo up to 3 months before histology studies were done. Microglial reconstruction through confocal imaging illustrates that the presence of graphene on polyimide reduced the number of microglial cells in the retina compared to polyimide alone, thereby indicating a high biocompatibility. This study highlights an interesting approach to assess material biocompatibility in a tissue model of central nervous system, the retina, which is easily accessed optically and surgically.
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The safety and biocompatibility of graphene electrodes for retinal implants has been assessed.
“Recently, the safety and biocompatibility of graphene electrodes for retinal implants has been assessed [172].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [172]
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References 44 · Cited by 36
- Authors
- Nguyen, D., Valet, M., Dégardin, J., Boucherit, L., Illa, X., de la Cruz, J., del Corro, E., Bousquet, J., Garrido, J. A., Hébert, C., & Picaud, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Institut Català de Nanociència i Nanotecnologia (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Nguyen, Diep
- Picaud, Serge
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2021-03-04
- Volume
- 15
- Pages
- 615256-615256
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC7969870
- OpenAlex
- W3135779714
- Cited by
- 36
- References
- 44
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 6 · 2022: 6 · 2021: 1
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- Funders
- Horizon 2020 Framework Programme (881603)
- Agence Nationale de la Recherche (ANR-10-LABX-65, ANR-18-IAHU-0001)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Keywords
- graphene electrodes, retinal prosthesis, biocompatibility, foreign body reaction, glial scar, microglia, brain-computer interface, electrical stimulation
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