Nucleus accumbens core and shell are necessary for reinforcer devaluation effects on pavlovian conditioned responding
Open accessAbstract
The nucleus accumbens (NA) has been hypothesized to be part of a circuit in which cue-evoked information about expected outcomes is mobilized to guide behavior. Here we tested this hypothesis using a Pavlovian reinforcer devaluation task, previously applied to assess outcome-guided behavior after damage to regions such as the orbitofrontal cortex and amygdala that send projections to NA. Rats with sham lesions or neurotoxic lesions of either the core or shell subdivision of NA were trained to associate a 10-s CS+ with delivery of three food pellets. After training, half of the rats in each lesion group received food paired with illness induced by LiCl injections; the remaining rats received food and illness unpaired. Subsequently, responding to the CS+ was assessed in an extinction probe test. Both sham and lesioned rats conditioned to the CS+ and formed a conditioned taste aversion. However only sham rats reduced their conditioned responding as a result of reinforcer devaluation; devalued rats with lesions of either core or shell showed levels of responding that were similar to lesioned, non-devalued rats. This impairment was not due to the loss of motivational salience conferred to the CS+ in lesioned rats as both groups responded similarly for the cue in conditioned reinforcement testing. These data suggest that NA core and shell are part of a circuit necessary for the use of cue-evoked information about expected outcomes to guide behavior.
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Conditioned responses themselves exhibit sensitivity to outcome devaluation procedures.
“CRs themselves exhibit sensitivity to outcome devaluation procedures”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [57]
The Nacc core and shell have both been shown to be necessary for the effects of outcome-specific devaluation on preparatory conditioned responses.
“the Nacc core and shell have both been shown to be necessary for the effects of outcome-specific devaluation on preparatory CRs [56,57].”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [57]
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References 50 · Cited by 40
Research works printed but not linked: 2
- Balleine B. W. Corbit L. H. (2005). Double dissociation of nucleus accumbens core and shell on the general and outcome-specific forms of pavlovian-instrumental transfer. Soc. Neurosci. Abstracts 71.16. PMC3208020 21849539
- Schoenbaum G. Setlow B. Gallagher M. (2002). “Orbitofrontal cortex: modeling prefrontal function in rats,” in The Neuropsychology of Memory, eds Squire L. Schacter D. (New York: Guilford Press), 463– 477
- Authors
- Singh, T.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Singh, Teghpal
- Venue
- Frontiers in Integrative Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2010
- Volume
- 4
- Pages
- 126-126
- ISSN
- 1662-5145 (ISSN-L)
- PMC
- PMC2981418
- OpenAlex
- W2117342733
- Cited by
- 40
- References
- 50
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 5
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- other-oa
- Locations
- Frontiers in Integrative Neuroscience (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (R01AG027097)
- National Institute on Drug Abuse
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- nucleus accumbens, nucleus accumbens core, nucleus accumbens shell, reinforcer devaluation, conditioned taste aversion, conditioned reinforcement, motivational salience, lesion studies
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