Nanocarrier system: An emerging strategy for bioactive peptide delivery
Open accessAbstract
Compared with small-molecule synthetic drugs, bioactive peptides have desirable advantages in efficiency, selectivity, safety, tolerance, and side effects, which are accepted by attracting extensive attention from researchers in food, medicine, and other fields. However, unacceptable barriers, including mucus barrier, digestive enzyme barrier, and epithelial barrier, cause the weakening or the loss of bioavailability and biostability of bioactive peptides. The nanocarrier system for bioactive peptide delivery needs to be further probed. We provide a comprehensive update on the application of versatile delivery systems for embedding bioactive peptides, including liposomes, polymer nanoparticles, polysaccharides, hydrogels, and self-emulsifying delivery systems, and further clarify their structural characterization, advantages, and disadvantages as delivery systems. It aims to provide a reference for the maximum utilization of bioactive peptides. It is expected to be an effective strategy for improving the bioavailability and biostability of bioactive peptides.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nanocarriers made out of biopolymers (e.g. chitosan-alginate nanoparticles) increase solubility of peptide molecules and enable pH-dependent release in the intestine, important for delivery of algal peptides with antihypertensive or antidiabetic properties.
“Nanocarriers made out of biopolymers (e.g. chitosan-alginate nanoparticles) increase the solubility of peptide molecules and enable pH-dependent release in the intestine, which is of particular importance in the delivery of algal peptides with antihypertensive or antidiabetic properties [216].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [216]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 138 · Cited by 63
Research works printed but not linked: 1
- [118]Li HL Xu L He XD Li JX. Exploration on antimicrobial activity of self-assembled peptide (RADA16-I). World Latest Med Inf. (2017) 66: 19– 21. 10.19613/j.cnki.1671-3141.2017.66.008 · DOI
- Authors
- Zhang, X., Li, X., Zhao, Y., Zheng, Q., Wu, Q., & Yu, Y.
- Affiliations
- Shaoyang University (CN)
- Corresponding author
- Wu, Qiang
- Yu, Yougui
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2022-12-05
- Volume
- 9
- Pages
- 1050647-1050647
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC9760884
- OpenAlex
- W4310673863
- Cited by
- 63
- References
- 138
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 9 · 2023: 4
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- bioactive peptides, nanocarriers, peptide delivery systems, bioavailability, biostability, liposomes, polymeric nanoparticles, polysaccharides, hydrogels, mucus barrier, epithelial barrier function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
