The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Recent Advances in the Treatment of Breast Cancer
Open accessAbstract
Breast cancer (BC) is the most common malignancy in women. It is classified into a few major molecular subtypes according to hormone and growth factor receptor expression. Over the past few years, substantial advances have been made in the discovery of new drugs for treating BC. Improved understanding of the biologic heterogeneity of BC has allowed the development of more effective and individualized approach to treatment. In this review, we provide an update about the current treatment strategy and discuss the various emerging novel therapies for the major molecular subtypes of BC. A brief account of the clinical development of inhibitors of poly(ADP-ribose) polymerase, cyclin-dependent kinases 4 and 6, phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, histone deacetylation, multi-targeting tyrosine kinases, and immune checkpoints for personalized treatment of BC is included. However, no targeted drug has been approved for the most aggressive subtype-triple negative breast cancer (TNBC). Thus, we discuss the heterogeneity of TNBC and how molecular subtyping of TNBC may help drug discovery for this deadly disease. The emergence of drug resistance also poses threat to the successful development of targeted therapy in various molecular subtypes of BC. New clinical trials should incorporate advanced methods to identify changes induced by drug treatment, which may be associated with the upregulation of compensatory signaling pathways in drug resistant cancer cells.
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Cites
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
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Palbociclib and letrozole in advanced breast cancer
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Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer
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Ribociclib as first-line therapy for HR-positive, advanced breast cancer
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“They were shown to significantly improve median PFS by 10 months (16) and PFS rate by 20% after 18 months (17), respectively, compared to letrozole alone.”
BackgroundSledge, G. W., Toi, M., Neven, P., Sohn, J., Inoue, K., Pivot, X., Burdaeva, O., Okera, M., Masuda, N., Kaufman, P. A., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.73.7585 · Cited by 1,680 · cited 1×
“As second-line treatment in combination with fulvestrant in HR+/HER2− advanced BC, palbociclib and abemaciclib were demonstrated to significantly prolong median PFS by 5 months (18) and 7 months (19), respectively, compared to fulvestrant alone.”
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Recent advances of highly selective CDK4/6 inhibitors in breast cancer
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Cited by
Current State of Breast Cancer Diagnosis, Treatment, and Theranostics
Bhushan, A., Gonsalves, A., & Menon, J. U. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050723 · Cited by 298
Hu, J., Hu, B., Wang, M., Xu, F., Miao, B., Yang, C.-Y., Wang, M., Liu, Z., Hayes, D. F., Chinnaswamy, K., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01572 · Cited by 268
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Metadata
- Authors
- Tong, C. W. S., Wu, M., Cho, W. C. S., & To, K. K. W.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-14
- Volume
- 8
- Pages
- 227-227
- ISSN
- 2234-943X (ISSN-L)
- OpenAlex
- W2807500538
- Cited by
- 399
- References
- 10
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tong, C. W. S., Wu, M., Cho, W. C. S., & To, K. K. W. (2018). Recent Advances in the Treatment of Breast Cancer. Frontiers in Oncology. https://doi.org/10.3389/fonc.2018.00227
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
