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The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis
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“Nonetheless, CD44 expression varies widely between CRC stages [86,87]. This heterogeneity may limit uniform nanoparticle uptake across entire tumors.”
From Chitosan-Based Drug Delivery Systems for Targeted Chemotherapy in Colorectal Cancer: A Scoping Review (2025) · cites this paper as [87]
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Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
Research works printed but not linked: 99
- Bray, 2018, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin., 68, 394, 10.3322/caac.21492 · DOI · Paper page
- Van Cutsem, 2014, Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann Oncol., 25, iii1, 10.1093/annonc/mdu260 · DOI · Paper page
- Weiser, 2018, AJCC 8th Edition: colorectal cancer, Ann Surg Oncol., 25, 1454, 10.1245/s10434-018-6462-1 · DOI · Paper page
- Pardal, 2003, Morrison: applying the principles of stem-cell biology to cancer, Nat Rev Cancer., 3, 895, 10.1038/nrc1232 · DOI
- Liu, 2017, RAD51 mediates resistance of cancer stem cells to PARP inhibition in triple-negative breast cancer, Clin Cancer Res., 23, 514, 10.1158/1078-0432.ccr-15-1348 · DOI
- Singh, 2004, Identification of human brain tumour initiating cells, Nature., 432, 396, 10.1038/nature03128 · DOI
- O'Brien, 2007, A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature., 445, 106, 10.1038/nature05372 · DOI
- Dalerba, 2007, Phenotypic characterization of human colorectal cancer stem cells, Proc Natl Acad Sci USA., 104, 10158, 10.1073/pnas.0703478104 · DOI
- Du, 2008, CD44 is of functional importance for colorectal cancer stem cells, Clin Cancer Res., 14, 6751, 10.1158/1078-0432.ccr-08-1034 · DOI
- Nagano, 2004, Mechanism and biological significance of CD44 cleavage, Cancer Sci., 95, 930, 10.1111/j.1349-7006.2004.tb03179.x · DOI · Paper page
- Cheng, 2006, Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion, Mol Cell Biol., 26, 362, 10.1128/mcb.26.1.362-370.2006 · DOI
- Vigetti, 2008, Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging, J Biol Chem., 283, 4448, 10.1074/jbc.M709051200 · DOI
- Naor, 1997, CD44: structure, function, and association with the malignant process, Adv Cancer Res., 71, 241, 10.1016/S0065-230X(08)60101-3 · DOI
- Ponta, 2003, CD44: from adhesion molecules to signalling regulators, Nat Rev Mol Cell Biol., 4, 33, 10.1038/nrm1004 · DOI
- Negi, 2012, Role of CD44 in tumour progression and strategies for targeting, J Drug Target., 20, 561, 10.3109/1061186x.2012.702767 · DOI
- Zoller, 2011, CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?, Nat Rev Cancer., 11, 254, 10.1038/nrc3023 · DOI
- Bates, 2001, A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells, Cancer Res., 61, 5275
- Fujita, 2002, CD44 signaling through focal adhesion kinase and its anti-apoptotic effect, FEBS Lett., 528, 101, 10.1016/s0014-5793(02)03262-3 · DOI
- Wang, 2006, Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer, Arch Otolaryngol Head Neck Surg., 132, 771, 10.1001/archotol.132.7.771 · DOI
- Miletti-Gonzalez, 2005, The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer, Cancer Res., 65, 6660, 10.1158/0008-5472.can-04-3478 · DOI
- Kim, 2005, Hyaluronic acid induces osteopontin via the phosphatidylinositol 3-kinase/Akt pathway to enhance the motility of human glioma cells, Cancer Res., 65, 686, 10.1158/0008-5472.686.65.3 · DOI
- Yu, 1999, Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion, Genes Dev., 13, 35, 10.1101/gad.13.1.35 · DOI
- Chen, 2014, Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis, BMC Cancer., 14, 15, 10.1186/1471-2407-14-15 · DOI
- Li, 2013, Clinical significance of CD44 variants expression in colorectal cancer, Tumori., 99, 88, 10.1700/1248.13794 · DOI
- Wu, 2015, Evaluation of the correlation of KAI1/CD82, CD44, MMP7 and beta-catenin in the prediction of prognosis and metastasis in colorectal carcinoma, Diagn Pathol., 10, 176, 10.1186/s13000-015-0411-0 · DOI
- Hong, 2015, Expression of the cancer stem cell markers CD44 and CD133 in colorectal cancer: an immunohistochemical staining analysis, Ann Coloproctol., 31, 84, 10.3393/ac.2015.31.3.84 · DOI
- Lugli, 2010, Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer, Br J Cancer., 103, 382, 10.1038/sj.bjc.6605762 · DOI
- Jungling, 2002, Expression of CD44v6 has no prognostic value in patients with colorectal cancer, Z Gastroenterol., 40, 229, 10.1055/s-2002-25152 · DOI
- Chen, 2014, The prognostic value of CD44 expression in gastric cancer: a meta-analysis, Biomed Pharmacother., 68, 693, 10.1016/j.biopha.2014.08.001 · DOI
- Luo, 2016, Prognostic value of CD44 expression in patients with hepatocellular carcinoma: meta-analysis, Cancer Cell Int., 16, 47, 10.1186/s12935-016-0325-2 · DOI
- Li, 2015, Prognostic value of CD44 expression in renal cell carcinoma: a systematic review and meta-analysis, Sci Rep., 5, 13157, 10.1038/srep13157 · DOI
- Lin, 2017, The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis, Cancer Cell Int., 17, 8, 10.1186/s12935-016-0376-4 · DOI
- Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, BMJ., 339, b2535, 10.1136/bmj.b2535 · DOI · Paper page
- Bhatavdekar, 1998, Overexpression of CD44: a useful independent predictor of prognosis in patients with colorectal carcinomas, Ann Surg Oncol., 5, 495, 10.1007/BF02303641 · DOI
- Sokmen, 2001, Prognostic value of CD44 expression in colorectal carcinomas, Anticancer Res., 21, 4121
- Ropponen, 1998, Expression of CD44 and variant proteins in human colorectal cancer and its relevance for prognosis, Scand J Gastroenterol., 33, 301, 10.1080/00365529850170900 · DOI
- Visca, 2002, Role and prognostic significance of CD44s expression in colorectal cancer, Anticancer Res., 22, 2671
- Ngan, 2007, A multivariate analysis of adhesion molecules expression in assessment of colorectal cancer, J Surg Oncol., 95, 652, 10.1002/jso.20638 · DOI
- Horst, 2009, Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer, Cancer Invest., 27, 844, 10.1080/07357900902744502 · DOI
- Seo, 2015, Prognostic implications of adhesion molecule expression in colorectal cancer, Int J Clin Exp Pathol., 8, 4148
- Cai, 2016, Correlation of multiple proteins with clinic-pathological features and its prognostic significance in colorectal cancer with signet-ring cell component, Eur Rev Med Pharmacol Sci., 20, 3358
- Mohamed, 2018, The prognostic value of cancer stem cell markers (Notch1, ALDH1, and CD44) in primary colorectal carcinoma, J Gastrointest Cancer., 10.1007/s12029-018-0156-6 · DOI
- Qu, 2017, Prognostic value of E-cadherin-, CD44-, and MSH2-associated nomograms in patients with stage II and III colorectal cancer, Transl Oncol., 10, 121, 10.1016/j.tranon.2016.12.005 · DOI
- Iseki, 2017, Significance of E-cadherin and CD44 expression in patients with unresectable metastatic colorectal cancer, Oncol Lett., 14, 1025, 10.3892/ol.2017.6269 · DOI
- Ribeiro, 2016, KRAS mutation associated with CD44/CD166 immunoexpression as predictors of worse outcome in metastatic colon cancer, Cancer Biomark., 16, 513, 10.3233/cbm-160592 · DOI
- Zavrides, 2005, Prognostic evaluation of CD44 expression in correlation with bcl-2 and p53 in colorectal cancer, Folia Histochem Cytobiol., 43, 31
- Huh, 2009, Expression of standard CD44 in human colorectal carcinoma: association with prognosis, Pathol Int., 59, 241, 10.1111/j.1440-1827.2009.02357.x · DOI · Paper page
- Choi, 2009, Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma, World J Gastroenterol., 15, 2258, 10.3748/wjg.15.2258 · DOI
- Saigusa, 2012, Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy, Int J Oncol., 41, 1643, 10.3892/ijo.2012.1598 · DOI
- Fernandez, 2004, CD44s expression in resectable colorectal carcinomas and surrounding mucosa, Cancer Invest., 22, 878, 10.1081/cnv-200039658 · DOI
- Vizoso, 2004, Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer, J Cancer Res Clin Oncol., 130, 679, 10.1007/s00432-004-0596-1 · DOI
- Saito, 2013, CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer, Oncol Rep., 29, 1570, 10.3892/or.2013.2273 · DOI
- Ozawa, 2014, Prognostic significance of CD44 variant 2 upregulation in colorectal cancer, Br J Cancer., 111, 365, 10.1038/bjc.2014.253 · DOI
- Kobel, 2004, Epithelial hyaluronic acid and CD44v6 are mutually involved in invasion of colorectal adenocarcinomas and linked to patient prognosis, Virchows Arch., 445, 456, 10.1007/s00428-004-1095-0 · DOI
- Zlobec, 2009, Systematic assessment of the prognostic impact of membranous CD44v6 protein expression in colorectal cancer, Histopathology., 55, 564, 10.1111/j.1365-2559.2009.03421.x · DOI
- Koretz, 1995, Effect of CD44v6 on survival in colorectal carcinoma, Lancet., 345, 327, 10.1016/S0140-6736(95)90320-8 · DOI
- Haruyama, 1999, Clinicopathological significance of the expression of CD44v2 in colorectal cancer, Anticancer Res., 19, 4421
- Parmar, 1998, Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints, Stat Med., 17, 2815, 10.1002/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8 · DOI
- Altman, 2011, How to obtain the confidence interval from a P value, BMJ., 343, d2090, 10.1136/bmj.d2090 · DOI
- Sauerbrei, 2018, Reporting recommendations for tumor marker prognostic studies (REMARK): an abridged explanation and elaboration, J Natl Cancer Inst., 110, 803, 10.1093/jnci/djy088 · DOI
- Higgins, 2002, Quantifying heterogeneity in a meta-analysis, Stat Med., 21, 1539, 10.1002/sim.1186 · DOI · Paper page
- DerSimonian, 1986, Meta-analysis in clinical trials, Control Clin Trials., 7, 177, 10.1016/0197-2456(86)90046-2 · DOI · Paper page
- Begg, 1994, Operating characteristics of a rank correlation test for publication bias, Biometrics., 50, 1088, 10.2307/2533446 · DOI · Paper page
- Egger, 1997, Bias in meta-analysis detected by a simple, graphical test, BMJ., 315, 629, 10.1136/bmj.315.7109.629 · DOI · Paper page
- Katoh, 2015, Cancer stem cell marker in circulating tumor cells: expression of CD44 variant exon 9 is strongly correlated to treatment refractoriness, recurrence and prognosis of human colorectal cancer, Anticancer Res., 35, 239
- Ichikawa, 1994, Positive relationship between expression of CD44 and hepatic metastases in colorectal cancer, Pathobiology., 62, 172, 10.1159/000163907 · DOI
- Kunimura, 2009, The relationships between loss of standard CD44 expression and lymph node, liver metastasis in T3 colorectal carcinoma, J Gastrointest Cancer., 40, 115, 10.1007/s12029-009-9100-0 · DOI
- Wang, 2018, [Expression of stem cell markers CD44 and Lgr5 in colorectal cancer and its relationship with lymph node and liver metastasis], Zhonghua Yi Xue Za Zhi., 98, 2899, 10.3760/cma.j.issn.0376-2491.2018.36.005 · DOI
- Isozaki, 1998, Expression of cell adhesion molecule CD44 and sialyl Lewis A in gastric carcinoma and colorectal carcinoma in association with hepatic metastasis, Int J Oncol., 13, 935
- Zhao, 2015, CD44v6 expression in patients with stage II or stage III sporadic colorectal cancer is superior to CD44 expression for predicting progression, Int J Clin Exp Pathol., 8, 692
- Gotley, 1996, Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer, Br J Cancer., 74, 342, 10.1038/bjc.1996.364 · DOI
- Gunther, 2002, Prediction of distant metastases after curative surgery for rectal cancer, J Surg Res., 103, 68, 10.1006/jsre.2001.6312 · DOI
- Avoranta, 2012, Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence, World J Gastroenterol., 18, 4549, 10.3748/wjg.v18.i33.4549 · DOI
- Ismaiel, 2016, Detection of cancer stem cells in colorectal cancer: histopathological and immunohistochemical study, Open Access Maced J Med Sci., 4, 543, 10.3889/oamjms.2016.126 · DOI
- Amirghofran, 2008, Evaluation of CD44 and CD44v6 in colorectal carcinoma patients: soluble forms in relation to tumor tissue expression and metastasis, J Gastrointest Cancer., 39, 73, 10.1007/s12029-009-9062-2 · DOI
- Ishida, 2000, Immunohistochemical expression of the CD44 variant 6 in colorectal adenocarcinoma, Surg Today., 30, 28, 10.1007/pl00010042 · DOI
- Yamane, 1999, Soluble CD44 variant 6 as a prognostic indicator in patients with colorectal cancer, Oncology., 56, 232, 10.1159/000011970 · DOI
- Michl, 2015, Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system, Pathol Res Pract., 211, 601, 10.1016/j.prp.2015.05.006 · DOI
- Choi, 2017, Expression of epithelial-mesenchymal transition and cancer stem cell markers in colorectal adenocarcinoma: clinicopathological significance, Oncol Rep., 38, 1695, 10.3892/or.2017.5790 · DOI
- Neumann, 2015, Cancer stem cell markers are associated with distant hematogenous liver metastases but not with peritoneal carcinomatosis in colorectal cancer, Cancer Invest., 33, 354, 10.3109/07357907.2015.1047507 · DOI
- Huh, 2014, Pretreatment expression of 13 molecular markers as a predictor of tumor responses after neoadjuvant chemoradiation in rectal cancer, Ann Surg., 259, 508, 10.1097/SLA.0b013e31829b3916 · DOI
- Jing, 2015, Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases, Int J Oncol., 46, 1582, 10.3892/ijo.2015.2844 · DOI
- Rohani, 2017, CD44 standard isoform; not a good marker for colon cancer, Int J Cancer Manag., 10, 5, 10.5812/ijcm.9166 · DOI
- Gallatin, 1983, A cell-surface molecule involved in organ-specific homing of lymphocytes, Nature., 304, 30, 10.1038/304030a0 · DOI
- Prince, 2007, Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma, Proc Natl Acad Sci USA., 104, 973, 10.1073/pnas.0610117104 · DOI
- Hurt, 2008, CD44+ CD24(-) prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis, Br J Cancer., 98, 756, 10.1038/sj.bjc.6604242 · DOI
- Al-Hajj, 2003, Prospective identification of tumorigenic breast cancer cells, Proc Natl Acad Sci USA., 100, 3983, 10.1073/pnas.0530291100 · DOI
- Zhang, 2008, Identification and characterization of ovarian cancer-initiating cells from primary human tumors, Cancer Res., 68, 4311, 10.1158/0008-5472.can-08-0364 · DOI
- Inoue, 2015, Aberrant splicing of estrogen receptor, HER2, and CD44 genes in breast cancer, Genet Epigenet., 7, 19, 10.4137/geg.s35500 · DOI
- Xiaoping, 2015, Expression and significance of CD44 and p-AKT in pancreatic head cancer, World J Surg Oncol., 13, 334, 10.1186/s12957-015-0746-8 · DOI
- Biddle, 2013, CD44 staining of cancer stem-like cells is influenced by down-regulation of CD44 variant isoforms and up-regulation of the standard CD44 isoform in the population of cells that have undergone epithelial-to-mesenchymal transition, PLoS ONE., 8, e57314, 10.1371/journal.pone.0057314 · DOI
- Brown, 2011, CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression, J Clin Invest., 121, 1064, 10.1172/jci44540 · DOI
- Mashita, 2014, Epithelial to mesenchymal transition might be induced via CD44 isoform switching in colorectal cancer, J Surg Oncol., 110, 745, 10.1002/jso.23705 · DOI
- Krishnamachary, 2012, Hypoxia regulates CD44 and its variant isoforms through HIF-1alpha in triple negative breast cancer, PLoS ONE., 7, e44078, 10.1371/journal.pone.0044078 · DOI
- Ishimoto, 2011, CD44 variant regulatesredox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth, Cancer Cell., 19, 387, 10.1016/j.ccr.2011.01.038 · DOI · Paper page
- Barbour, 2003, Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3, Cancer Res., 63, 887
- Gunthert, 1991, A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells, Cell., 65, 13, 10.1016/0092-8674(91)90403-L · DOI
- Weg-Remers, 1998, Decreased expression of CD44 splicing variants in advanced colorectal carcinomas, Eur J Cancer., 34, 1607, 10.1016/S0959-8049(98)00177-4 · DOI
- Katoh, 1994, Characterization of soluble CD44 in the circulation of mice, Levels are affected by immune activity and tumor growth. J Immunol., 153, 3440
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Metadata
- Authors
- Wang, Z., Tang, Y., Xie, L., Huang, A., Xue, C., Gu, Z., Wang, K., & Zong, S.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2019-04-30
- Volume
- 9
- ISSN
- 2234-943X
- PMC
- PMC6503057
- Cited by
- 100
- References
- 1
- Funders
- National Natural Science Foundation of China
- Shanghai University of Traditional Chinese Medicine
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