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Breast Cancer Survivorship, Quality of Life, and Late Toxicities
Open accessAbstract
Breast cancer is the most frequent cancer in women: in 2018, almost two million cases have been diagnosed all over the world and it represents the principal cause of death from a neoplastic disease in women. In the past years, breast cancer prognosis has significantly improved over time: currently 5-year survival rates are in the range of 90%, and 10-year survival is about 80%. This improvement has been mostly observed in western countries, due to high coverage and compliance with screening programs, leading to early diagnosis, i.e., when the disease is at a subclinical level, and to an improvement in tumor molecular characterization and innovative systemic treatments. Yet the identification of different biological breast cancer subtypes prompted the development of innovative targeted agents and improved treatment personalization. On the other hand, longer survival rates and increasing proportions of cured patients require dedicated strategies to manage long-term sequelae of breast cancer treatments, with particular attention to quality of life. This review analyzes the most important issues, potentially occurring with cancer treatments, concerning long-term sequelae and quality of life, to define a global approach to breast cancer survivorship.
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“In addition to somatic side effects of the therapy, such as neurotoxicity and cardiotoxicity, lymphoedema or pain [6–8], increased tumour-related stress or mental illnesses such as anxiety and depression play a central role in follow-up care.”
From The BrEasT cancer afTER-CARE (BETTER-CARE) programme to improve breast cancer follow-up: design and feasibility study results of a cluster-randomised complex intervention trial (2024) · cites this paper as [7]
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Metadata
- Authors
- Nardin, S., Mora, E., Varughese, F. M., D'Avanzo, F., Vachanaram, A. R., Rossi, V., Saggia, C., Rubinelli, S., & Gennari, A.
- Affiliations
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- Corresponding author
- Gennari, Alessandra
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2020-06-16
- Volume
- 10
- Pages
- 864-864
- ISSN
- 2234-943X (ISSN-L)
- PMC
- PMC7308500
- OpenAlex
- W3036457113
- Cited by
- 330
- References
- 39
- Citations by year
- 2026: 47 · 2025: 85 · 2024: 83 · 2023: 55 · 2022: 37 · 2021: 21 · 2020: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- breast cancer survivorship, quality of life, late toxicity, breast cancer screening, breast cancer subtypes, targeted therapy, personalized treatment
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