Current Situation of Medication Adherence in Hypertension
Open accessAbstract
Despite increased awareness, poor adherence to treatments for chronic diseases remains a global problem. Adherence issues are common in patients taking antihypertensive therapy and associated with increased risks of coronary and cerebrovascular events. Whilst there has been a gradual trend toward improved control of hypertension, the number of patients with blood pressure values above goal has remained constant. This has both personal and economic consequences. Medication adherence is a multifaceted issue and consists of three components: initiation, implementation, and persistence. A combination of methods is recommended to measure adherence, with electronic monitoring and drug measurement being the most accurate. Pill burden, resulting from free combinations of blood pressure lowering treatments, makes the daily routine of medication taking complex, which can be a barrier to optimal adherence. Single-pill fixed-dose combinations simplify the habit of medication taking and improve medication adherence. Re-packing of medication is also being utilized as a method of improving adherence. This paper presents the outcomes of discussions by a European group of experts on the current situation of medication adherence in hypertension.
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Non-adherence prevails, so hypertension is not under desirable control.
“Nevertheless, since non-adherence prevails, hypertension is not under desirable control [10, 11].”
From The effect of the mobile “blood pressure management application” on hypertension self-management enhancement: a randomized controlled trial (2021) · cites this paper as [11]
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- Authors
- Vrijens, B., Antoniou, S., Burnier, M., de la Sierra, A., & Volpe, M.
- Affiliations
- University of Liège (BE)
- Barts Health NHS Trust (GB)
- Centre Hospitalier Universitaire Vaudois (CH)
- Istituto Neurologico Mediterraneo (IT)
- Corresponding author
- Vrijens, Bernard
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2017-03-01
- Volume
- 8
- Pages
- 100-100
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC5331678
- OpenAlex
- W2601416412
- Cited by
- 292
- References
- 30
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 25 · 2023: 38 · 2022: 34 · 2021: 48 · 2020: 48 · 2019: 23 · 2018: 34 · 2017: 7
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- IRIS (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- Funders
- Daiichi Sankyo Europe
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- medication adherence, hypertension, antihypertensive therapy, blood pressure control, medication burden, fixed-dose combination, electronic monitoring, adherence measurement, cardiovascular events, chronic disease management
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