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Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review

Zhang, Chaohe, Sheng, Jiyao, Li, Guangquan, Zhao, Lihong, Wang, Yicun, Yang, Wei, Yao, Xiaoxiao, Sun, Lihuan, Zhang, Zhuo, Cui, Ranji·2020·Frontiers in Pharmacology
DOI 10.3389/fphar.2019.01461PMC PMC6974675
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Figure 1 Possible mechanism of the anti-tumor effects induced by berberine based on systems pharmacology. VEGFR, vascular endothelial growth factor receptor; Akt, serine/threonine kinase; ERK, extracellular regulated protein kinases activation; MMP, Matrix Metalloproteinase; AMPK, AMP-activated protein kinase; BAX, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; ROS, reactive oxygen species.
Figure 1 Possible mechanism of the anti-tumor effects induced by berberine based on systems pharmacology. VEGFR, vascular endothelial growth factor receptor; Akt, serine/threonine kinase; ERK, extracellular regulated protein kinases activation; MMP, Matrix Metalloproteinase; AMPK, AMP-activated protein kinase; BAX, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; ROS, reactive oxygen species.CC BY · PubMed Central
Figure 2 Structure of berberine and compounds 1-8.
Figure 2 Structure of berberine and compounds 1-8.CC BY · PubMed Central
Figure 3 Structure of compounds 15-17.
Figure 3 Structure of compounds 15-17.CC BY · PubMed Central

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Metadata

Authors
Zhang, C., Sheng, J., Li, G., Zhao, L., Wang, Y., Yang, W., Yao, X., Sun, L., Zhang, Z., & Cui, R.
Venue
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Published
2020-01-15
Volume
10
ISSN
1663-9812
DOI
10.3389/fphar.2019.01461
PMC
PMC6974675
Cited by
102
References
0
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Natural Science Foundation of China (31571126)

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CoChat. (2026). Citation check: Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review. https://app.cochat.ai/papers/10.3389/fphar.2019.01461
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Zhang, C., Sheng, J., Li, G., Zhao, L., Wang, Y., Yang, W., Yao, X., Sun, L., Zhang, Z., & Cui, R. (2020). Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2019.01461