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Macrophage cytotherapy on liver cirrhosis
Open accessAbstract
Macrophages, an essential cell population involved in mediating innate immunity in the host, play a crucial role on the development of hepatic cirrhosis. Extensive studies have highlighted the potential therapeutic benefits of macrophage therapy in treating hepatic cirrhosis. This review aims to provide a comprehensive overview of the various effects and underlying mechanisms associated with macrophage therapy in the context of hepatic cirrhosis.
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“In murine experiments, these MoMFs express high levels of lymphocyte antigen 6 complex locus C (Ly-6C), known as Ly-6Chigh macrophages [79].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [79]
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“Macrophage transplantation therapy ameliorates liver fibrosis primarily by: 1) enhancing the expression of growth factors, such as HGF, to improve the proliferation and differentiation of LPCs and hepatocytes; 2) reducing inflammatory damage to protect hepatocytes; 3) inducing apoptosis of aHSCs by recruiting and activating natural killer (NK) cells while reducing HSC activation to reduce ECM”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [79]
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Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
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Triantafyllou, E., Pop, O. T., Possamai, L. A., Wilhelm, A., Liaskou, E., Singanayagam, A., Bernsmeier, C., Khamri, W., Petts, G., Dargue, R., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313615 · Cited by 226
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Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver
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Cited by
Sorted by citations
Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2
“…3) inducing apoptosis of aHSCs by recruiting and activating nat-ural killer (NK) cells while reducing HSC activation to reduce ECM synthesis; 4) upregulating MMPs such as MMP-2, MMP-9, and MMP-13, while downregulating TIMPs, including TIMP-1 and TIMP-2, to promote ECM degradation [78, 79].”
Metadata
- Authors
- Ping, D., Peng, Y., Hu, X., & Liu, C.
- Affiliations
- Shanghai University of Traditional Chinese Medicine (CN)
- Corresponding author
- Liu, Chenghai
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2023-12-15
- Volume
- 14
- Pages
- 1265935-1265935
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC10757375
- OpenAlex
- W4389792691
- Cited by
- 6
- References
- 8
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- SSRN Electronic Journal (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- macrophage therapy, liver cirrhosis, macrophages, innate immunity, cell therapy, therapeutic mechanisms
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