Brain-gut-microbe communication in health and disease
Grenham, Sue, Clarke, Gerard, Cryan, John F., Dinan, Timothy G.·2011·Frontiers in Physiology
Cited by (954)
Items 701–800 of 954
- Gut Homeostasis; Microbial Cross Talks in Health and Disease ManagementGauri S Khatri, Christine Kurian, Asha Anand, Kuppusamy Alagesan Paari · 2021 · Current Research in Nutrition and Food Science Journal
- Infant colic: where is the line between norm and pathology, the role of disruption of the intestinal microbiomeL. D. Panova · 2021 · Meditsinskiy sovet = Medical Council
- PsychobioticsSabrina Mörkl, Mary Butler, Franziska Cichini, John F. Cryan, Timothy G. Dinan · 2020 · Oxford University Press eBooks
- Germ-free Mice Technology: Opportunity for Future ResearchAshish Jain, Anand Maurya · 2022 · Nutritional neurosciences
- Investigating the Influence of Probiotic Bacteria on Anemia and White Blood Cells Count in Cancer Patients Undergoing Chemotherapy and Radiation TherapyMaryam Azizpour, Parvaneh Jafari, Ali Arash Anushiravani · 2022 · Multidisciplinary Cancer Investigation
- A LIGAÇÃO ENTRE O INTESTINO E A DEPRESSÃO: UMA REVISÃO SISTEMÁTICA DOS MECANISMOS ENVOLVIDOS NO EIXO INTESTINO-CÉREBRONathalia Rayane Ferreira Moreira, Jacqueline Volpato Simões Tecchio, Mônica Regina da Costa Marques, Kelly Ribeiro Moura Barboza, Clarynda Nazareth Lôla da Costa, Marcia Cristina Ceriaco Favacho, Josimeire Pedrosa Gomes, Cristiane Andrade Maciel Nassif, Jadislene Estevam da Silva Costa, Aline Martha Trevezani de Souza et al. · 2023 · Revista Ibero-Americana de Humanidades, Ciências e Educação
- Probiotics Show Promise as a Novel Natural Treatment for Neurological DisordersPreeti Jha, Neha Dangi, Shikha Sharma · 2023 · Current Pharmaceutical Biotechnology
- Faecal microbiota transplantation (FMT) in Norwegian outpatients with mild to severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): protocol for a 12-month randomised double-blind placebo-controlled trialLinn Kallbekken Skjevling, Rasmus Goll, Hege Marie Hanssen, Peter Holger Johnsen · 2024 · BMJ Open
- Influence of diet on autismFeng Jin, Yunfeng Duan, XiaoLi WU · 2015 · Chinese Science Bulletin (Chinese Version)
- Do Obese Bacteria Make us “Want them”? Intestinal Microbiota, Mesocorticolimbic Circuit and Non-Homeostatic FeedingJocelyn Urrutia-Piñones, Javiera Illanes-González, Alejandra López-Aguilera, Marcela Julio‐Pieper, Javier A. Bravo · 2018 · Current Behavioral Neuroscience Reports
- Probiotics and Applications to ConstipationElena Scarpato, Vincenzo Coppola, Annamaria Staiano · 2019 · Elsevier eBooks
- Derin Kızartılmış Ayçiçeği Yağının Bir Fare Modelinde Sperm Parametreleri Üzerindeki Etkileri: Probiyotiklerin Koruyucu Etkisi Var mı?Serkan Sayıner, Nurhayat GÜLMEZ, Zafer Sabit, Murat Gülmez · 2019 · Kafkas Universitesi Veteriner Fakultesi Dergisi
- Psychobiotics and Brain-Gut Microbiota AxisSima Taheri, Morteza Khomeiri · 2019 · Iranian Journal of Medical Microbiology
- Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysisNatália Alvarenga Borges, Najla Elias Farage, A.F. Heras Barros, Dennis de Carvalho Ferreira, Denis P. Fouque, Denise Mafrea · 2016 · Nutrición Hospitalaria
- Impact of Probiotics and Gut Microbiota on Host BehaviorSarabjit Singh Kanwar, Sohini Walia, Sakshi Sharma · 2016 · Springer eBooks
- Gut Microbes: The Miniscule Laborers in the Human BodySuma Sarojini · 2018 · Elsevier eBooks
- Effects of exercise training with Lactobacillus plantarum intake on ionized calcium‐binding adaptor molecule 1, glial fibrillary acidic protein, interleukin‐6 and interleukin‐1β in cuprizone‐induced demyelination mouse model of multiple sclerosisDonya Sajedi, Ramin Shabani, Alireza Elmieh · 2021 · Clinical and Experimental Neuroimmunology
- The Human Microbiome, Conventional Medicine, and HomeopathyRonald D. Whitmont · 2020 · Homeopathy
- Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegansQi Jia, Drew Young, Qixin Zhang, Derek Sieburth · 2024 · eLife
- Host Transcriptome and Microbial Variation in Relation to Visceral HyperalgesiaChristopher J. Costa, Stephanie M. Prescott, Nicolaas H. Fourie, Sarah K. Abey, LeeAnne B. Sherwin, Bridgett Rahim-Williams, Paule V. Joseph, Hugo Fernando Posada-Quintero, Rebecca K. Hoffman, Wendy A. Henderson · 2025 · Nutrients
- Immunity in Parkinson's disease - the role of adaptive and auto-immune responses and gut-microbiome axisAditi S Iyengar, Peter Robert Dunkley, Phillip W. Dickson · 2025 · Journal of Neuroimmunology
- Relação entre microbiota intestinal e depressãoRafaela da Silva Ratto, Max dos Santos Afonso, Suely Ribeiro Bampi, Nathalia Brandão Peter, Chirle de Oliveira Raphaelli, Cléber Gibbon Ratto · 2020 · Research Society and Development
- What we have learned to date from the omics approach to non-Alzheimer's dementiasMehmet Demırci, Özge Altıntaş Kadırhan · 2022 · Journal of Integrative Neuroscience
- Link of gut microbiome with risk of type 2 diabetes mellitusAlhanouf M. Alkhammash, Wafa A. Alshehri, Amani Matook Alhozali, Ahmed Bahieldin · 2022 · Journal of Contemporary Medical Sciences
- Research progress on the relationship between traumatic brain injury and brain‐gut‐microbial axisJie Yu, Yun‐Xin Chen, Jin‐Wei Wang, Haitao Wu · 2024 · Ibrain
- Physiology of Gut Water Balance and Pathomechanics of DiarrheaTed H. Elsasser, Shollie Faulkenberg · 2024 · Springer eBooks
- Changes in the intestinal microbiota in patients with a major depressive episode and ulcerative colitisAntonio Maria D’Onofrio, Gaspare Filippo Ferrajoli, Rosaria Calia, Lorenza OGGIANO, Federica Di Vincenzo, Valentina Petito, Eleonora Maggio, Daniele Napolitano, Letizia Masi, Elisa Schiavoni et al. · 2024 · Minerva Psychiatry
- The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral SclerosisMohamed Jamal Saadh, Shahad Mohammed Dhiaa, Pooja Bansal, Hasan Khalid Dabis, Ashu Katyal, Vivek Saraswat, Azher Abdulmutaleb Ibrahim, Radi Usama Kadem, Mohammed Ubaid · 2025 · Current Behavioral Neuroscience Reports
- WuMei-pill alleviates Parkinson's disease induced by dopamine neuron damage in mice by regulating the gut-brain-microbiome axisZuowen Zhang, Lan Shen, Yinyou Bai, Shishuang Li, Shu‐Mei Wang · 2025 · Journal of Radiation Research and Applied Sciences
- Mode of Birth and Specific Learning Disabilities: A Systematic ReviewMaria A. Makri, Dimitrios I. Chaniotis, Victoria V Vivilaki, Effie G. Papageorgiou · 2025 · Cureus
- Functional Gastrointestinal Disorders in ChildrenFlavia Indrio, Giuseppe Riezzo · 2013 · World review of nutrition and dietetics
- Methane matters: from blue-tinged moos, to boozy roos, and the health of humans tooEmily C. Hoedt, Páraic Ó Cuív, Mark Morrison · 2016 · Animal Frontiers
- The gut response to foodEamonn M.M. Quigley · 2017 · Current Opinion in Gastroenterology
- GUT MICROBIOTA GUT MICROBIOTA: SUCCINCT OVERVIEW OF IMPACTS ON HUMAN PHYSIQUE AND CURRENT RESEARCH STATUS WITH FUTURE ASPECTSMd Imran Hossain, Redwanul Islam, Sanjida Islam Mimi, Zilhas Ahmed Jewel, Utsho Ali Haider · 2020 · International Journal of Advancement in Life Sciences Research
- Роль кишечной микробиоты в патогенезе колоректального рака. Обзор литературных данныхИ. А. Карасев, Ol’ga Aleksandrovna Malikhova, Т. С. Давыдкина · 2020 · Malignant tumours
- Bağırsak-Beyin Eksenine Biyokimyasal BakışÜmmühan Fulden Aydın, Abdullah Tuli · 2021 · Arşiv Kaynak Tarama Dergisi
- Probiotics Suppress the Depression: A Look at the Possible Mechanisms of ActionLeila Khalili, Riyaz Zafar Sayyed · 2022 · Springer eBooks
- An Investigation Into What Factors Influence Patterns of Clinical Presentation in Adult-Onset Celiac DiseaseKatie O’Shaughnessy, W. A. Stack, Tríona Hayes, Elizabeth Kenny, Lucina Jackson · 2022 · Cureus
- Psychobiotics in the treatment of depression: a new look at mental health – a systematic search reviewTaiane Coelho, Raquel Kerpel · 2022 · Revista Científica Multidisciplinar Núcleo do Conhecimento
- Psychophysiological Responses of Humans during Seed-Sowing Activity Using Soil Inoculated with Streptomyces rimosusNa-Yoon Choi, Sin-Ae Park, Ye-Rim Lee, Choong Hwan Lee · 2022 · International Journal of Environmental Research and Public Health
- The Importance of the Microbiome in the GutMark Morrison, Nida Murtaza, Nicholas Joseph Talley · 2023 · Springer eBooks
- Mind Meets Body: Lifestyle Medicine and Positive Psychology Interventions for SchoolJolanta Burke, Pádraic J. Dunne · 2024 · Advances in mental health and addiction
- ТРАДИЦИОННЫЕ И СОВРЕМЕННЫЕ РАСТВОРИМЫЕ ПРЕБИОТИКИ ПРИРОДНОГО ПРОИСХОЖДЕНИЯ. Публикация 1. Про- и пребиотики в традиционной медицине и современной концепции питанияМария Алексеевна Киселева, Татьяна Леонидовна Киселева, Е.В. Хлебников · 2024 · Традиционная медицина
- Role of mast cells and probiotics in the regulation of intestinal barrier functionAnders Karlsson · 2013 · Linköping University Electronic Press eBooks
- Neurobiology of Sleep and Microbiomics in AgingLinda J. Larson‐Prior, Gohar Azhar, David Davila, Se‐Ran Jun, Aaron S. Kemp, Intawat Nookaew, Jeanne Y. Wei, Trudy M. Wassenaar · 2017 · OBM Neurobiology
- Role of Gut Microbiome in NeuromodulationSuganya Kannan, Govindan Krishnamoorthy, Prabha Palanichamy, Marudhamuthu Murugan · 2017 · Springer eBooks
- Neonate gut colonization: The rise of a social brainKaterina Karaivazoglou, Christos Konstantakis, Stelios F. Assimakopoulos, Christos K Triantos · 2019 · Neurogastroenterology & Motility
- Comunicación bidireccional de la microbiota intestinal en el desarrollo del sistema nervioso central y en la enfermedad de ParkinsonMargarita Gómez-Chavarı́n, M. Rocio Morales-Gómez · 2017 · Archivos de Neurociencias
- The Paradigm-Shift toward the Next Generation of DrugsSara Diani, Claudio Lombardo · 2020 · Preprints.org
- Association of Prebiotic and Probiotic Food Consumption with Depression, Anxiety and Stress among College Going StudentsManjula Suri, Vandana Sabharwal, Pragya Kaushik, Anushka Joshi, Aayushi, Sunita Aggarwal · 2022 · The Indian Journal of Nutrition and Dietetics
- Saberes ancestrais como promoção à saúde física e mental: um olhar agroecológicoFlávia Silva Barbosa · 2023 · ODEERE
- Gut microbiota: role of biofilms in human healthDhanshree Jha, Rahul Kumar · 2024 · Elsevier eBooks
- Parkinson’s Disease and the faecal microbiota transplantation. Review of current knowledgeMarcin Dudek, Julia Silldorff, M Zajac, Tomasz Fura, Zuzanna Felińska, Stanisław Anczyk, Oliwia Iszczuk, Magdalena Gajkiewicz, Radosław Zaucha · 2024 · Quality in Sport
- Lacticaseibacillus paracasei LPB27 ameliorates depressive-like behaviors in CUMS rats by inhibiting IDO-1 and regulating tryptophan metabolismLi Huang, Jiaxin Xiao, Lyu Jie, Xinru Wei, Yunqin Zheng, Xinrui Zhao, Zewei Ma, Jiajie Xue, Xinyue Yu, Xiaolei Ze et al. · 2025 · Food Science and Human Wellness
- How gut microbes affect Parkinson’s disease: an editorialRabia Nasir, Abdul Haseeb, Muhammad Saqlain Mustafa, Abdullah Mussarat, Laiba Ali, Muhammad Ashir Shafique, Khabab Abbasher Hussien Mohamed Ahmed · 2025 · Annals of Medicine and Surgery
- Prevalence of psychiatric disorders in patients of irritable bowel syndrome fulfilling Rome IV criteria: An observational studyRanita Bhattacharya, Kumari Pratima, Preeti, Shivlok Narayan Ambedkar · 2025 · Journal of Family Medicine and Primary Care
- The prevention effect of prebiotics and probiotics on bisphenol A caused neurotoxicity and mood disorders from the perspective of regulating gut microbiotaYidan Cai, Youmeng Chen, Xinrong Gong, Yili Chen, Wenyan Qin, Xin Zhang · 2025 · Journal of the Science of Food and Agriculture
- High flavonoid diet alleviates chronic stress in cancer patients by optimization of the gut microbiotaYue Li, Jiaqi Dong, Shuai Wang, Renhui Xiong, Xinmei Kang · 2025 · Food & Function
- The Gut Microbiome as a Modulator of Traumatic Brain Injury Pathology and SymptomsCole Vonder Haar, Marta Celorrio, Kris M. Martens, Stuart Howard Friess, Sonia Villapol, Randall J. Urban, Richard B. Pyles, Richelle Mychasiuk, Dennis W. Simon, Amanda M. Dave · 2025 · Journal of Neuroscience
- Oral Administrations of Short-Chain Fatty Acids or Probiotics Extend the Survival Times and Mitigate the Neuropathological Damages in the Scrapie-Infected HamstersYuan Wang, Dong-Lin Liang, Rundong Cao, A Ruhan, Jia-Feng Zeng, Bing Xu, Jiandong Li, Weiwei Zhang, Liping Gao, Kang Xiao et al. · 2025 · Molecular Neurobiology
- The impact of polystyrene nanoplastics on the chicken gut and liver: Based on transcriptomics and microbiomicsZhili Li, Shibin Chen, Su Su, Yiran Wang, Youyou Song, Haigang Wu, Xianguo Yi, Zhizhong Xiao, Qingming Qin · 2026 · Poultry Science
- Gut-Brain Axis as a Closed-Loop Molecular Communication NetworkBeyza E. Ortlek, Özgür B. Akan · 2026 · IEEE Transactions on Molecular Biological and Multi-Scale Communications
- Gut microbiota, cellular metabolism, and exercise: A review of microbial metabolites, mechanisms, and performance implicationsNitesh Kumar, Saritha Keluth, Ruchi Pandey, Krishnaprasad, Rakesh Krishna Kovela, Nirmal Mazumder, Saumya Srivastava, K. Vaishali, Mukesh Kumar Sinha · 2026 · Clinical Epidemiology and Global Health
- Analysis of treatment-naïve gut microbiota in children with new-onset epilepsyAyumi Fujishiro, Shoji Tsuji, Shohei Akagawa, Sadayuki Fujishiro, Kiyotaka Murakami, Atsushi Araki, Kazunari Kaneko · 2026 · Pediatric Research
- Underwater Noise Induces Cognitive Impairments in Resource-Directed Exploratory Behaviors in Black Rockfish ( Sebastes schlegelii ) via Disruption of the Microbiota–Gut–Brain and Hypothalamic–Pituitary–Interrenal AxesShanshan Duan, Xin Li, Raquel O. Vasconcelos, Haixiang Zhao, Junjie Su, Lele Wu, Zongwei Liu, Xian Li · 2026 · Environmental Science & Technology
- Microbial shifts in early life: the pediatric gut microbiome and its role in health and diseaseSonali Waghmode, Rajlakshmi Viswanathan, Vishal Koligudde, Pooja Umare, Mallika Lavania · 2026 · Gut Microbes
- Probiotika in der AllergiebehandlungMatthias F. Kramer · 2015 · HNO Nachrichten
- The effect of probiotics on skinJiang Chang, Aafke A. Duizendstra, Renate Jansen, Ana Jimena, Pacheco Gutierrez, Tian Rui Zhao, Carel Weijers, Willemien Lommen, Jetske Ultee, Matthijs Boog · 2014
- ADVANCES IN TRANSLATIONAL SCIENCEJoseph H. Sellin, Sanjay K. Murthy, Martin Goetz, Arthur W. Hoffman, Ralf Kießlich · 2012
- Escherichia coli revisité, ami ou ennemi ?Marie‐Laure Joly‐Guillou · 2016 · Revue Francophone des Laboratoires
- Tracing the Evolutionary Origin of the Gut–Brain AxisThomas C. G. Bosch · 2018 · Springer eBooks
- Le microbiote intestinal gouverne-t-il notre cerveau ?Guillaume B. Fond · 2018 · Annales Médico-psychologiques revue psychiatrique
- Neurodevelopment, Intestinal Function, and AutismEdwin Chau-Leung Yu · 2018 · Neonatal and Pediatric Medicine
- Evaluation of Gut Microbiota in Patients With Vulvovestibular SyndromeLaura Coda, Paola Cassis, Stefania Angioletti, Cristina Angeloni, Stefania Piloni, Cristian Testa · 2021 · Journal of Clinical Medicine Research
- Finding Colon Cancer- and Colorectal Cancer-Related Microbes Based on Microbe–Disease Association PredictionYu Chen, Hongjian Sun, Mengzhe Sun, Changguo Shi, Hongmei Sun, Xiaoli Shi, Binbin Ji, Jinpeng Cui · 2021 · Frontiers in Microbiology
- The role of the gut microbiota in Parkinson’s diseaseN I Verugina, Oleg Semenovich Levin, Elena A. Lyashenko · 2021 · S S Korsakov Journal of Neurology and Psychiatry
- Pathophysiological Role of Gut Microbiota Affecting Gut–Brain Axis and Intervention of Probiotics and Prebiotics in Autism Spectrum DisorderFirdosh Shah, Mitesh Dwivedi · 2022 · Springer eBooks
- The Interplay between the Microbiota and Enterohemorrhagic Escherichia coliReed Pifer, Vanessa Sperandio · 2015 · ASM Press eBooks
- Gut Microbiota Regulation of Cerebral StrokeKaushlendra Kumar, Kumari Hema, Amit Kumar Tripathi · 2022 · Nutritional neurosciences
- What do experimental animal models of mood disorders tell clinicians about influence of probiotics on the gut-brain axis?Natasza Staniak, Ewa Piaseczna-Spitaleri, Grażyna Biała · 2022 · Postępy Higieny i Medycyny Doświadczalnej
- A modulação intestinal como fator relevante no enfrentamento do quadro de depressãoYanataysha de Souza Lima Primavera, Taís Freitas Bezerra, Ruane Ramos de Souza, Francisca Marta Nascimento de Oliveira Freitas, José Carlos de Sales Ferreira · 2022 · Research Society and Development
- Cognitive, Emotional, Behavioral and Physiological Evaluation of the Relationship Between Brain and Gut MicrobiotaSelim Günüç, Aylin Şendemir · 2022 · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry
- Mood disturbance, but not overall diet quality, is associated with fecal microbiome diversity in free-living adultsKristen S. Smith, Molly M. Morris, Casey D. Morrow, Josh R. Novak, Michael D. Roberts, Andrew D. Frugé · 2023 · Nutritional Neuroscience
- The relationship between dietary fiber intake and the state of cognitive function in middle and old age in the population of high cardiovascular riskS. V. Shishkin, A. V. Titarenko, A. K. Kuntsevich, Evgeniy G. Verevkin, О. Д. Рымар, Sofia K. Malyutina · 2023 · Ateroscleroz
- Parkinson's Disease, Diet and Gut Microbiota AlterationsDavid Armando Guach-Hevia · 2023 · Journal of Neurodegenerative Disorders
- The Role of the Gut Microbiota in the Development of Colorectal CancerШумилова Виктория Николаевна, A. Е. Goncharov, Латария Элгуджа Лаврентьевич, Batyrbek I. Aslanov · 2024 · Fundamental and Clinical Medicine
- Role of Gut Brain and Gut Oral Axis in Progression of Parkinson’s Disease with Special Focus on Gut MicrobesAshwin Rajeev, Indranil Chattopadhyay · 2024 · Springer eBooks
- Multi-Source Data with Laplacian Eigenmaps and Denoising Autoencoder for Predicting Microbe-Disease Associations via Convolutional Neural NetworkXiujuan Lei, Ya-Li Chen, Yi Feng Pan · 2025 · Journal of Computer Science and Technology
- Gut Microbiota and White Matter Integrity: A Two-Sample Mendelian Randomization AnalysisLan Zhang, Xiao‐Wei Pang, Luyang Zhang, Li‐Fang Zhu, Wan-Ning Li, Yun‐Hui Chu, Luo‐Qi Zhou, Dai‐Shi Tian, Chuan Qin, Lian Chen · 2025 · eNeuro
- Lessons from theDrosophila microbiotaEmmaL Walton · 2015 · Biomedical Journal
- RETRACTED CHAPTER: Changing Paradigm of Probiotics from Functional Foods to Biotherapeutic AgentsEldin Maliyakkal Johnson, Yong‐Gyun Jung, Ying‐Yu Jin, Seung Hwan Yang, R. Jayabalan, Joo Won Suh · 2018 · Springer eBooks · Retracted
- Some Mechanistical and Computational Aspects on the Correlations that Might Exist between Irritable Bowel Syndrome Versus Sleep Patterns and DisturbancesRoxana Oana Cojocariu, Alin Stelian Ciobica, Ioana-Miruna Balmuș, Lucian Gorgan, Manuela Pădurariu, C Stanciu, Anca Victorita Trifan · 2019 · E-Health and Bioengineering Conference (EHB)
- The role of the gastrointestinal system and gut microbiota in Parkinson's diseaseJade E. Kenna, Ryan S. Anderton · 2020 · Elsevier eBooks
- Pharmaceutical significance and recent developments in utilizing bacterial enzymesSrinivasa Rao Vulichi, Rupak Kumar, Appa Rao Chippada, Durga Srinivasa Murthy Sistla, Venkata Rao Chunduri, Suman Kapur, Krishna Murthy Naidu Galla · 2020 · Elsevier eBooks
- Irritable bowel syndrome - risk factors, pathogenesis and treatment optionsMagdalena Wójcik, Justyna Dąbrowska, Julita Szarpak, Damian Bator, Hubert Nieścior, Joanna Milanowska · 2020 · Journal of Education Health and Sport
- The Future of Gastrointestinal Physiology: 2020 and BeyondStephen Jacob Pandol · 2021 · Frontiers in Physiology
- Micronutrients and Depression: Is There Any Association?Kenny Kheng-Yee Ong · 2022 · Nutritional neurosciences
- Modulação da microbiota intestinal na infância e suas interferências no sistema imunológicoLetícia Duque Estrada de Souza Martins · 2022 · Research Society and Development
- Deciphering the Gut Microbial Contribution to the Etiology of Autism DevelopmentIvan Kok Seng Yap, François‐Pierre Martin · 2014 · Molecular and integrative toxicology
- Gut Microbiome Drives the Development of Colorectal Cancers and Potential Therapeutic InterventionsSutripto Ghosh, Bijayata Patra, Tamalika Chakraborty · 2023 · International Journal of Pharmaceutical Sciences Review and Research