YAP-Mediated Mechanotransduction in Skeletal Muscle
Open accessAbstract
Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and functionality is determined by its mechanical and physical environment. Processing intra- and extracellular mechanical signaling cues contributes to the regulation of cell growth, survival, migration and differentiation. Yes-associated Protein (YAP), a transcriptional coactivator downstream of the Hippo pathway and its paralog, the transcriptional co-activator with PDZ-binding motif (TAZ), were recently found to play a key role in mechanotransduction in various tissues including skeletal muscle. Furthermore, YAP/TAZ modulate myogenesis and muscle regeneration and abnormal YAP activity has been reported in muscular dystrophy and rhabdomyosarcoma. Here, we summarize the current knowledge of mechanosensing and -signaling in striated muscle. We highlight the role of YAP signaling and discuss the different routes and hypotheses of its regulation in the context of mechanotransduction.
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YAP/TAZ obligatorily interact with TEAD transcription factors to strongly drive expression of c-Myc.
“YAP/TAZ obligatorily interact with TEAD transcription factors to strongly drive the expression of c-Myc”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [43]
The YAP section says that active YAP regulates TEAD transcription factors, and the Figure 1 caption says YAP activates TEAD-mediated gene expression. The copy does not establish that YAP/TAZ must interact with TEAD, or that this interaction strongly drives c-Myc expression; its listed prominent YAP targets do not include c-Myc. (LLM, conf=0.88)
Experimental — accuracy not yet measuredc-Myc acts as direct effector, binding to rDNA promoters to orchestrate Pol I activity and nucleolar expansion.
“c-Myc acts as the direct effector, binding to rDNA promoters to orchestrate Pol I activity and nucleolar expansion”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [43]
The YAP section describes YAP’s transcription-factor partners and target genes, but does not address c-Myc binding to rDNA promoters. Searches for c-Myc, Pol I, and nucleolar expansion found no passage in our copy addressing the claimed mechanism. The cited paper’s text therefore does not verify this attribution. (LLM, conf=0.74)
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References 140 · Cited by 145
- Authors
- Fischer, M., Rikeit, P., Knaus, P., & Coirault, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Freie Universität Berlin (DE)
- Corresponding author
- Coirault, Catherine
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2016-02-16
- Volume
- 7
- Pages
- 41-41
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC4754448
- OpenAlex
- W2290648886
- Cited by
- 145
- References
- 140
- Citations by year
- 2026: 20 · 2025: 14 · 2024: 17 · 2023: 10 · 2022: 10 · 2021: 22 · 2020: 20 · 2019: 13 · 2018: 12 · 2017: 6 · 2016: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft
- Université Pierre et Marie Curie
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- YAP, TAZ, mechanotransduction, skeletal muscle, Hippo signaling pathway, mechanosensing, myogenesis, muscle regeneration, muscular dystrophy, rhabdomyosarcoma, striated muscle, mechanosensitive signaling
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