Emerging roles of hydrogen sulfide in inflammatory and neoplastic colonic diseases
Open accessAbstract
Hydrogen sulfide (H2S) is a toxic gas that has been recognized as an important mediator of many physiological processes, such as neurodegeneration, regulation of inflammation, blood pressure, and metabolism. In the human colon, H2S is produced by both endogenous enzymes and sulfate-reducing bacteria (SRB). H2S is involved in the physiological and pathophysiological conditions of the colon, such as inflammatory bowel disease (IBD) and colorectal cancer (CRC), which makes the pharmacological modulation of H2S production and metabolism a potential chemical target for the treatment of colonic diseases. However, the exact mechanisms and pathways by which H2S-mediates normal physiological function and disease in the colon are not fully understood. Besides, the production and release of H2S are modulated by both endogenous and exogenous factors. This review will discuss the production and storage of H2S, its biological roles and the emerging importance in physiology and pathology of IBD and CRC.
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There remains conflicting evidence regarding the precise role of H2S in the gut.
“Indeed, there remains conflicting evidence regarding the precise role of H2S in the gut[344,347].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [347]
Increased H2S formation by SRB can promote oxidant formation, impair colonic epithelial H2S detoxification and induce cytotoxicity and disruption of intestinal barrier integrity, thereby driving local and systemic inflammation.
“while on the other, increased H2S formation by SRB can promote oxidant formation, impair colonic epithelial H2S detoxification and induce cytotoxicity and disruption of intestinal barrier integrity, thereby driving local and systemic inflammation[344,347,352,353].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [347]
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References 80 · Cited by 146
- Authors
- Guo, F.-F., Yu, T.-C., Hong, J., & Fang, J.-Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Fang, Jing-Yuan
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2016-05-03
- Volume
- 7
- Pages
- 156-156
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC4853395
- OpenAlex
- W2346039291
- Cited by
- 146
- References
- 80
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 22 · 2023: 23 · 2022: 17 · 2021: 21 · 2020: 16 · 2019: 11 · 2018: 8 · 2017: 1 · 2016: 4
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Physical Sciences › Engineering › Mechanical Engineering › Catalysis and Hydrodesulfurization Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- hydrogen sulfide, inflammatory bowel disease, colorectal cancer, sulfate-reducing bacteria, colonic inflammation, H2S signaling, colonic physiology, therapeutic target
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