The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Adenosine Methylation in Arabidopsis mRNA is Associated with the 3′ End and Reduced Levels Cause Developmental Defects
Open accessAbstract
We previously showed that the N6-methyladenosine (m(6)A) mRNA methylase is essential during Arabidopsis thaliana embryonic development. We also demonstrated that this modification is present at varying levels in all mature tissues. However, the requirement for the m(6)A in the mature plant was not tested. Here we show that a 90% reduction in m(6)A levels during later growth stages gives rise to plants with altered growth patterns and reduced apical dominance. The flowers of these plants commonly show defects in their floral organ number, size, and identity. The global analysis of gene expression from reduced m(6)A plants show that a significant number of down-regulated genes are involved in transport, or targeted transport, and most of the up-regulated genes are involved in stress and stimulus response processes. An analysis of m(6)A distribution in fragmented mRNA suggests that the m(6)A is predominantly positioned toward the 3' end of transcripts in a region 100-150 bp before the poly(A) tail. In addition to the analysis of the phenotypic changes in the low methylation Arabidopsis plants we will review the latest advances in the field of mRNA internal methylation.
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Cites
The control of the false discovery rate in multiple testing under dependency
Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106 · cited 1×
“However, in a recent paper (Jia et al., 2011) it is shown that the primary function of the human fat mass and obesity associated protein (FTO) is to remove the methyl groups from N 6 methylated adenosines in mRNA.”
Cited by
m6A modulates neuronal functions and sex determination in Drosophila
Lence, T., Akhtar, J., Bayer, M., Schmid, K., Spindler, L., Ho, C. H., Kreim, N., Andrade-Navarro, M. A., Poeck, B., Helm, M., et al. (2016) · Nature · doi:10.1038/nature20568 · Cited by 544
Růžička, K., Zhang, M., Campilho, A., Bodi, Z., Kashif, M., Saleh, M., Eeckhout, D., El‐Showk, S., Li, H., Zhong, S., et al. (2017) · New Phytologist · doi:10.1111/nph.14586 · Cited by 486
Self-citationRecent advances in dynamic m 6 A RNA modification
Cao, G., Li, H.-B., Yin, Z., & Flavell, R. A. (2016) · Open Biology · doi:10.1098/rsob.160003 · Cited by 308
Self-citationThe proteins of mRNA modification: writers, readers, and erasers
Flamand, M. N., Tegowski, M., & Meyer, K. D. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052521-035330 · Cited by 164
m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases
Du, K., Zhang, L., Lee, T., & Sun, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1138-1 · Cited by 153
Metadata
- Authors
- Bodi, Z., Zhong, S., Mehra, S., Song, J., Graham, N., Li, H., May, S., & Fray, R. G.
- Venue
- Frontiers in Plant Science
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 3
- Pages
- 48-48
- ISSN
- 1664-462X (ISSN-L)
- OpenAlex
- W2127087804
- Cited by
- 313
- References
- 2
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bodi, Z., Zhong, S., Mehra, S., Song, J., Graham, N., Li, H., May, S., & Fray, R. G. (2012). Adenosine Methylation in Arabidopsis mRNA is Associated with the 3′ End and Reduced Levels Cause Developmental Defects. Frontiers in Plant Science. https://doi.org/10.3389/fpls.2012.00048
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