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Cited by 1,468Plant Stress Responses and TolerancePlant Molecular Biology ResearchRedox biology and oxidative stress

Mechanisms of ROS Regulation of Plant Development and Stress Responses

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Huang, Honglin, Ullah, Farhan, Zhou, Dao-Xiu, Yi, Ming, Zhao, Yu·2019·Frontiers in Plant Science
DOI 10.3389/fpls.2019.00800PMC PMC6603150
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Abstract

Plants are subjected to various environmental stresses throughout their life cycle. Reactive oxygen species (ROS) play important roles in maintaining normal plant growth, and improving their tolerance to stress. This review describes the production and removal of ROS in plants, summarizes recent progress in understanding the role of ROS during plant vegetative apical meristem development, organogenesis, and abiotic stress responses, and some novel findings in recent years are discussed. More importantly, interplay between ROS and epigenetic modifications in regulating gene expression is specifically discussed. To summarize, plants integrate ROS with genetic, epigenetic, hormones and external signals to promote development and environmental adaptation.

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  • Adverse in vitro conditions lead to overproduction of reactive oxygen species (ROS), which cause molecular disruptions including alterations in DNA methylation patterns, chromosomal aberrations, strand breakages, and point mutations.

    “These adverse conditions lead to the overproduction of reactive oxygen species (ROS), which are known to cause a variety of molecular disruptions, including alterations in DNA methylation patterns, chromosomal aberrations, strand breakages, and point mutations [43].”

    From Somaclonal Variation and Clonal Fidelity in Commercial Micropropagation: Challenges and Perspectives (2025) · cites this paper as [43]

    The Introduction says unfavorable circumstances increase ROS production and that high ROS levels can damage DNA. “Generation and Removal of ROS in Plants” specifically mentions DNA single-strand breakage, while “Interplay Between ROS and Epigenetic Modification” links ROS to DNA methylation. The paper does not establish these effects specifically for adverse in vitro conditions or report chromosomal aberrations and point mutations as outcomes. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • One of the primary contributors to somaclonal variation involves genetic mechanisms, which include modifications at the DNA level that result in permanent genetic changes.

    “One of the primary contributors to somaclonal variation involves genetic mechanisms, which include modifications at the DNA level that result in permanent genetic [43,44].”

    From Somaclonal Variation and Clonal Fidelity in Commercial Micropropagation: Challenges and Perspectives (2025) · cites this paper as [43]

    The Introduction states that ROS can cause irreversible DNA damage, and the section on ROS and epigenetic modification discusses chemical changes to DNA. Neither passage connects those changes to somaclonal variation or identifies genetic mechanisms as a primary contributor to it. Searches for somaclonal variation and permanent DNA changes found no passage making that connection. (LLM, conf=0.74)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Huang, H., Ullah, F., Zhou, D.-X., Yi, M., & Zhao, Y.
Affiliations
Huazhong Agricultural University (CN)
Corresponding author
Zhao, Yu
ORCID
Venue
Frontiers in Plant Science
Publisher
Frontiers Media SA
Published
2019-06-25
Volume
10
Pages
800-800
ISSN
1664-462X (ISSN-L)
DOI
10.3389/fpls.2019.00800
PMC
PMC6603150
OpenAlex
W2953462495
Cited by
1,468
References
0
Citations by year
2026: 138 · 2025: 245 · 2024: 278 · 2023: 257 · 2022: 250 · 2021: 217 · 2020: 71 · 2019: 9 · 2015: 1
FWCI
12.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Plant Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
reactive oxygen species, plant development, abiotic stress response, organogenesis, ROS homeostasis, epigenetic modifications, gene expression regulation, plant hormones, environmental adaptation

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