Mesolimbic Dopamine Transients in Motivated Behaviors: Focus on Maternal Behavior
Open accessAbstract
Phasic activity of the mesolimbic dopamine pathway - burst-firing of dopamine neurons and the resulting dopamine release events at striatal targets - have been associated with a variety of motivational events, such as novelty, salient stimuli, social interaction, and reward prediction. Over the past decade, advances in electrochemical techniques have allowed measurement of naturally occurring dopamine release events, or dopamine transients, in awake animals during ongoing behavior. Thus, a growing body of studies has revealed dynamic dopamine input to ventral striatum during motivated behavior in a variety of experimental paradigms. We propose that dopamine transients may be important neural signals in pup-directed aspects of maternal behavior, as preliminary data suggest that dopamine transients in dams are associated with pup cues. Measurements of dopamine transients may be useful to investigate not only typical maternal behavior but also maternal inattention induced by drug exposure or stress.
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Phasic dopamine signals in the VS, potentially influenced by input from midbrain, amygdala, and vmPFC, underlie non-social and social reward-seeking behaviors.
“Animal research using in vivo neurochemical methods indicates that phasic dopamine signals in the VS, potentially influenced by input from the midbrain, amygdala, and ventromedial prefrontal cortex (vmPFC), underlie non-social and social reward-seeking behaviors, including eating, drinking, reproduction, and other species-specific interactions [14].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [14]
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References 102 · Cited by 89
Research works printed but not linked: 1
- Yang H. Michael A. C. (2007). “In vivo fast-scan cyclic voltammetry of dopamine near microdialysis probes,” in Electrochemical Methods for Neuroscience, eds Michael A. C. Borland L. M. (Boca Raton: CRC Press), 489– 501 21204386
- Authors
- Robinson, D. L., Zitzman, D. L., & Williams, S. K.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Robinson, Donita L.
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 2
- Pages
- 23-23
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC3098725
- OpenAlex
- W2057246253
- Cited by
- 89
- References
- 102
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 23 · 2019: 1 · 2018: 3 · 2017: 9 · 2016: 5 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Foundation of Hope for Research and Treatment of Mental Illness
- Center for Alcohol Studies
- National Institutes of Health (AA011605)
- National Institute on Alcohol Abuse and Alcoholism (U01AA019972, R01AA018008, U24AA020024, P60AA011605)
- National Institute on Drug Abuse (DA022446, P01DA022446)
- Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mesolimbic dopamine system, maternal behavior, ventral striatum, dopamine release, motivated behavior, drug exposure, stress
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