The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes
Open accessAbstract
Major depression shortens life while the effectiveness of frontline treatments remains modest. Exercise has been shown to be effective both in reducing mortality and in treating symptoms of major depression, but it is still underutilized in clinical practice, possibly due to prevalent misperceptions. For instance, a common misperception is that exercise is beneficial for depression mostly because of its positive effects on the body ("from the neck down"), whereas its effectiveness in treating core features of depression ("from the neck up") is underappreciated. Other long-held misperceptions are that patients suffering from depression will not engage in exercise even if physicians prescribe it, and that only vigorous exercise is effective. Lastly, a false assumption is that exercise may be more harmful than beneficial in old age, and therefore should only be recommended to younger patients. This narrative review summarizes relevant literature to address the aforementioned misperceptions and to provide practical recommendations for prescribing exercise to individuals with major depression.
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“For example, stress is not only an indicator of burnout, but can also impact levels of depression, in turn impacting overall functioning and physical health (Belvederi Murri et al., 2019).”
From A randomised trial of Mindfulness-based Social Work and Self-Care with social workers (2023) · cites this paper as Belvederi Murri et al., 2019
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1 retracted
REMOVED: Exercise as antidepressant treatment: Time for the transition from trials to clinic?
Panteleimon Ekkekakis, A., & Murri, M. B. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.04.008 · Cited by 28
RetractedGarber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322
Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J. P. T., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32802-7 · Cited by 3,541
Walker, E. R., McGee, R. E., & Druss, B. G. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2502 · Cited by 2,976
Alexopoulos, G. S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66665-2 · Cited by 2,024
Exercise-based cardiac rehabilitation for coronary heart disease
Heran, B. S., Chen, J. M., Ebrahim, S., Moxham, T., Oldridge, N., Rees, K., Thompson, D. R., & Taylor, R. S. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001800.pub2 · Cited by 1,844
Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies
Schuch, F. B., Vancampfort, D., Firth, J., Rosenbaum, S., Ward, P. B., Silva, E. S., Hallgren, M., Ponce De Leon, A., Dunn, A. L., Deslandes, A. C., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17111194 · Cited by 1,763
Exercise Training for Blood Pressure: A Systematic Review and Meta‐analysis
Cornelissen, V. A., & Smart, N. A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.004473 · Cited by 1,683
Exercise as a treatment for depression: a meta-analysis adjusting for publication bias
Schuch, F. B., Vancampfort, D., Richards, J., Rosenbaum, S., Ward, P. B., & Stubbs, B. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.023 · Cited by 1,529 · cited 2×
“One such intervention is physical exercise, which is increasingly recognized as both an antidepressant agent (14) and a potent tool to delay mortality (15).”
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The Effects and Mechanisms of Exercise on the Treatment of Depression
Xie, Y., Wu, Z., Sun, L., Zhou, L., Wang, G., Xiao, L., & Wang, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.705559 · Cited by 209
Almas, K. (1999) · PubMed · Cited by 169
Systematic Review of Meta-Analyses: Exercise Effects on Depression in Children and Adolescents
Wegner, M., Amatriain‐Fernández, S., Kaulitzky, A., Murillo‐Rodríguez, E., Machado, S. E. D. C., & Budde, H. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00081 · Cited by 159
Depression and Objectively Measured Physical Activity: A Systematic Review and Meta-Analysis
Gianfredi, V., Blandi, L., Cacitti, S., Minelli, M., Signorelli, C., Amerio, A., & Odone, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17103738 · Cited by 148
Wanjau, M. N., Möller, H., Haigh, F., Milat, A., Hayek, R., Lucas, P., & Veerman, J. L. (2023) · AJPM Focus · doi:10.1016/j.focus.2023.100074 · Cited by 111
Metadata
- Authors
- Belvederi Murri, M., Ekkekakis, P., Magagnoli, M., Zampogna, D., Cattedra, S., Capobianco, L., Serafini, G., Calcagno, P., Zanetidou, S., & Amore, M.
- Affiliations
- University of Genoa (IT)
- Ospedale Policlinico San Martino (IT)
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2019-01-10
- Volume
- 9
- Pages
- 762-762
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC6335323
- OpenAlex
- W2910505094
- Cited by
- 163
- References
- 169
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 12 · 2023: 57 · 2022: 29 · 2021: 19 · 2020: 13 · 2019: 6
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Funders
- Heart and Stroke Foundation of Canada
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, physical activity, exercise prescription, mortality gap, clinical outcomes, elderly exercise, depression treatment
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