Heart Rate Variability for the Prediction of Treatment Response in Major Depressive Disorder
Open accessAbstract
Major depressive disorder (MDD) is one of the disabling diseases in the world-wide, and known to increase cardiac morbidity and mortality. Therefore, previous studies related heart rate variability (HRV) have been conducted to evaluate and diagnose MDD, and to predict treatment outcomes in patient with MDD. We reviewed extensively on the previous peer-reviewed publications associated with this issue, using Pub-Med. In this review article, we introduce the basic concept of HRV and HRV measures, and present several important findings associated with diagnosis and treatment prediction in MDD with using HRV parameters. Furthermore, we discuss the possible underlying mechanism of this phenomenon, and suggest several considerations for the future research.
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ANS function is purportedly modulated by the core-ICNs and one of the most robust ANS disturbances found in IDs is cardiac dysautonomia in the form of reduced HRV.
“ANS function is purportedly modulated by the core-ICNs and one of the most robust ANS disturbances found in IDs is cardiac dysautonomia in the form of reduced HRV [52, 96, 103, 280, 282–293].”
From Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders (2022) · cites this paper as [96]
The Introduction and ‘HRV for the Diagnosis of MDD’ section link autonomic dysfunction and reduced HRV to major depressive disorder; the ‘Low HF’ section also reports reduced HRV in various anxiety disorders. The ‘Possible Implication’ section describes central autonomic network regulation of cardiac autonomic activity, but does not identify that network as the core-ICNs or establish reduced HRV as one of the most robust ANS disturbances across IDs. No page numbers are available in our copy. (LLM, conf=0.84)
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References 84 · Cited by 32
- Authors
- Choi, K. W., & Jeon, H. J.
- Affiliations
- Korea University (KR)
- Samsung Medical Center (KR)
- Corresponding author
- Jeon, Hong Jin
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2020-06-30
- Volume
- 11
- Pages
- 607-607
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC7339656
- OpenAlex
- W3040634158
- Cited by
- 32
- References
- 84
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (NRF-2016M3C7A1947307, NRF-2017M3A9F1027323)
- College of Medicine, Korea University (K1922891)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- heart rate variability, major depressive disorder, treatment response prediction, antidepressant response, cardiac autonomic function, depression diagnosis
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