The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.
Associative and non-associative plasticity in Kenyon cells of the honeybee mushroom body
Open accessAbstract
The insect mushroom bodies are higher-order brain centers and critical for odor learning. We investigated experience dependent plasticity of their intrinsic neurons, the Kenyon cells (KCs). Using calcium imaging, we recorded KC responses and investigated non-associative plasticity by applying repeated odor stimuli. Associative plasticity was examined by performing appetitive odor learning experiments. Olfactory, gustatory and tactile antennal stimuli evoked phasic calcium transients in sparse ensembles of responding KCs. Repeated stimulation with an odor led to a decrease in KCs' response strength. The pairing of an odor (conditioned stimulus, CS) with a sucrose reward (unconditioned stimulus) induced a prolongation of KC responses. After conditioning, KC responses to a rewarded odor (CS+) recovered from repetition-induced decrease, while the responses to a non-rewarded odor (CS-) decreased further. The spatio-temporal pattern of activated KCs changed for both odors when compared with the response before conditioning but the change was stronger for the CS-. These results demonstrate that KC responses are subject to non-associative plasticity during odor repetition and undergo associative plasticity after appetitive odor learning.
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“It is well established that Hebbian-like plasticity in connections at the output of the mushroom body can support various forms of reinforcement learning [71,76–78].”
From Phenomenal interface theory: a model for basal consciousness (2025) · cites this paper as [77]
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Cites
Mushroom body memoir: from maps to models
Heisenberg, M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1074 · Cited by 1,286
Classical conditioning of proboscis extension in honeybees (Apis mellifera).
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Oscillations and Sparsening of Odor Representations in the Mushroom Body
Pérez-Orive, J., Mazor, O., Turner, G. C., Cassenaer, S., Wilson, R. I., & Laurent, G. (2002) · Science · doi:10.1126/science.1070502 · Cited by 792
Behavioral studies of Pavlovian conditioning
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Drosophila olfactory memory: single genes to complex neural circuits
Keene, A. C., & Waddell, S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2098 · Cited by 384
Punishment Prediction by Dopaminergic Neurons in Drosophila
Riemensperger, T. D., Völler, T., Stock, P., Buchner, E., & Fiala, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.042 · Cited by 350
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Giurfa, M., & Sandoz, J. (2012) · Learning & Memory · doi:10.1101/lm.024711.111 · Cited by 413
Caffeine in Floral Nectar Enhances a Pollinator's Memory of Reward
Wright, G. A., Baker, D. D., Palmer, M. J., Stabler, D., Mustard, J. A., Power, E. F., Borland, A. M., & Stevenson, P. C. (2013) · Science · doi:10.1126/science.1228806 · Cited by 380
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Metadata
- Authors
- Szyszka, P.
- Affiliations
- University of Konstanz (DE)
- Corresponding author
- Szyszka, Paul
- ORCID
- Szyszka, Paul
- Venue
- Frontiers in Systems Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2008
- Volume
- 2
- Pages
- 3-3
- ISSN
- 1662-5137 (ISSN-L)
- PMC
- PMC2526274
- OpenAlex
- W2022062647
- Cited by
- 121
- References
- 45
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 15 · 2012: 12
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Systems Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 515)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Kenyon cells, associative plasticity, non-associated plasticity, olfactory conditioning, sucrose reward, calcium imaging
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