Activity of free and liposome-encapsulated essential oil from Lavandula angustifolia against persister-derived biofilm of Candida auris
Open accessAbstract
The high virulence of Candida auris, a pathogen fungus considered as a global threat for public health, is due to its peculiar traits such as its intrinsic resistance to conventional antifungals. Its biofilm lifestyle certainly promotes the prolonged survival of C. auris after disinfection or antifungal treatments. In this work, for the first time, we detected persister cells in a biofilm of C. auris in a microwell plate model, following caspofungin treatment. Furthermore, we showed how persisters can progressively develop a new biofilm in situ, mimicking the re-colonization of a surface which may be responsible for recalcitrant infections. Plant-derived compounds, such as essential oils, may represent a valid alternative to combat fungal infections. Here, Lavandula angustifolia essential oil, as free or encapsulated in liposomes, was used to eradicate primary and persister-derived biofilms of C. auris, confirming the great potential of alternative compounds against emergent fungal pathogens. As in other Candida species, the action of essential oils against C. auris involves ROS production and affects the expression of some biofilm-related genes.
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Lavandula angustifolia essential oil provokes intracellular ROS accumulation and successfully eradicates caspofungin-triggered Candida auris biofilm persisters.
“Lavandula angustifolia essential oil, which can provoke intracellular reactive oxygen species (ROS) accumulation, has been found to successfully eradicate caspofungin-triggered Candida auris biofilm persisters [14].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [14]
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References 42 · Cited by 54
- Authors
- de Alteriis, E., Maione, A., Falanga, A., Bellavita, R., Galdiero, S., Albarano, L., Salvatore, M. M., Galdiero, E., & Guida, M.
- Affiliations
- Department of Biology, University of Naples ‘Federico II’, Via Cinthia, 80126 Naples, Italy
- University of Naples Federico II (IT)
- Institute for Sustainable Plant Protection (IT)
- Corresponding author
- Galdiero, Emilia
- ORCID
- Venue
- Antibiotics
- Publisher
- MDPI AG
- Published
- 2021-12-27
- Volume
- 11
- Issue
- 1
- Pages
- 26
- ISSN
- 2079-6382 (ISSN-L)
- PMC
- PMC8772840
- OpenAlex
- W4200276970
- Cited by
- 54
- References
- 42
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 14 · 2023: 12 · 2022: 11
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antibiotics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida auris, persister cells, biofilm, liposome encapsulation, caspofungin, antifungal resistance, reactive oxygen species, biofilm-related gene expression, plant-derived antifungal compounds
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