Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)
Open accessAbstract
The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease. Classical antioxidant and bioenergetic functions of the coenzyme have been taken into consideration, as well as novel mechanisms of action involving the redox-regulated activation of molecular pathways associated with anti-inflammatory activities. Cardiovascular research and fertility remain major fields of application of Coenzyme Q10, although novel applications, in particular in relation to topical application, are gaining considerable interest. In this respect, bioavailability represents a major challenge and the innovation in formulation aspects is gaining critical importance.
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CoQ10 lowers the level of plasma markers of muscular damage, including CK.
“Ulla et al. (2017) and Cirilli et al. (2021) stated that CoQ10 lowered the level of plasma markers of muscular damage, the CK level, which was in line with our results.”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Cirilli et al. 2021
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References 164 · Cited by 115
Research works printed but not linked: 1
- [104]Salviati L. Trevisson E. Doimo M. Navas P. Primary Coenzyme Q10 Deficiency GeneReviews((R)) Adam M.P. Ardinger H.H. Pagon R.A. Wallace S.E. Bean L.J.H. Mirzaa G. Amemiya A. University of Washington Seattle, WA, USA 2017 28125198
- Authors
- Cirilli, I., Damiani, E., Dludla, P. V., Hargreaves, I., Marcheggiani, F., Millichap, L. E., Orlando, P., Silvestri, S., & Tiano, L.
- Affiliations
- Università di Camerino (IT)
- Marche Polytechnic University (IT)
- South African Medical Research Council (ZA)
- Liverpool John Moores University (GB)
- Corresponding author
- Tiano, Luca
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2021-08-23
- Volume
- 10
- Issue
- 8
- Pages
- 1325
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC8389239
- OpenAlex
- W3195520647
- Cited by
- 115
- References
- 164
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 26 · 2023: 21 · 2022: 17 · 2021: 3 · 2019: 1
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Liverpool John Moores University (acceptedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Biofield Effects and Biophysics
- Keywords
- coenzyme Q10, antioxidant activity, bioenergetics, redox regulation, anti-inflammatory mechanism, cardiovascular health, fertility, topical application, bioavailability, formulation development, disease prevention
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