Application of Antioxidant Compounds in Bone Defect Repair
Open accessAbstract
Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair the function of cells involved in bone formation, posing a serious challenge for bone repair. Due to the potent ROS scavenging ability, as well as potential anti-inflammatory and immunomodulatory activities, antioxidants play an indispensable role in the maintenance and protection of bone health and have gained increasing attention in recent years. This narrative review aims to give an overview of the main research directions on the application of antioxidant compounds in bone defect repair over the past decade. In addition, the positive effects of various antioxidants and their biomaterial delivery systems in bone repair are summarized to provide new insights for exploring antioxidant-based strategies for bone defect repair.
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Elevated ROS concentrations directly impair mitochondrial function in BMSCs, inhibiting their osteogenic differentiation potential.
“Elevated ROS concentrations not only directly impair mitochondrial function in BMSCs, thereby inhibiting their osteogenic differentiation potential49, but also facilitate osteoclastogenesis by activating NF-κB signaling pathways50.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [49]
Section 3.3 (page not provided) identifies BMSCs as osteoblastic-lineage cells vulnerable to ROS-induced oxidative damage and says oxidative stress inhibits pathways involved in osteoblast differentiation. It does not say that ROS directly impair mitochondrial function in BMSCs or establish mitochondrial impairment as the cause of reduced osteogenic differentiation. (LLM, conf=0.87)
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References 170 · Cited by 39
- Authors
- Wang, J., Zhang, Y., Tang, Q., Zhang, Y., Yin, Y., & Chen, L.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Tongji University (CN)
- Corresponding author
- Yin, Ying
- Chen, Lili
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2024-06-28
- Volume
- 13
- Issue
- 7
- Pages
- 789
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC11273992
- OpenAlex
- W4400294787
- Cited by
- 39
- References
- 170
- Citations by year
- 2026: 21 · 2025: 14 · 2024: 4
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Key Research and Development Program of China (2021YFC2400404, 22207085)
- National Natural Science Foundation of China (2021YFC2400404, 22207085)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
- Keywords
- antioxidants, bone defect repair, reactive oxygen species, bone regeneration, anti-inflammatory activity, immunomodulation, bone health, bone formation
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