Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 31

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Inflammation, Peripheral Signals and Redox Homeostasis in Athletes Who Practice Different Sports

Luti, Simone, Modesti, Alessandra, Modesti, Pietro A.·2020·Antioxidants
DOI 10.3390/antiox9111065
Open this paper in CoChat — free account

Abstract

The importance of training in regulating body mass and performance is well known. Physical training induces metabolic changes in the organism, leading to the activation of adaptive mechanisms aimed at establishing a new dynamic equilibrium. However, exercise can have both positive and negative effects on inflammatory and redox statuses. In recent years, attention has focused on the regulation of energy homeostasis and most studies have reported the involvement of peripheral signals in influencing energy and even inflammatory homeostasis due to overtraining syndrome. Among these, leptin, adiponectin, ghrelin, interleukin-6 (IL6), interleukin-1β (IL1β) and tumour necrosis factor a (TNFa) were reported to influence energy and even inflammatory homeostasis. However, most studies were performed on sedentary individuals undergoing an aerobic training program. Therefore, the purpose of this review was to focus on high-performance exercise studies performed in athletes to correlate peripheral mediators and key inflammation markers with physiological and pathological conditions in different sports such as basketball, soccer, swimming and cycling.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/antiox9111065

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 75

  1. Magherini, 2019, Oxidative stress in exercise training: The involvement of inflammation and peripheral signals, Free. Radic. Res., 53, 1155, 10.1080/10715762.2019.1697438 · DOI
  2. Voracek, 2008, Relationships between finger-length ratios, ghrelin, leptin, IGF axis, and sex steroids in young male and female swimmers, Graefes Arch. Clin. Exp. Ophthalmol., 104, 523
  3. Wada, N., Hirako, S., Takenoya, F., Kageyama, H., Okabe, M., and Shioda, S. (2014). Leptin and its receptors. J. Chem. Neuroanat., 191–199. · DOI
  4. Wolsk, 2012, Human skeletal muscle releases leptin in vivo, Cytokine, 60, 667, 10.1016/j.cyto.2012.08.021 · DOI
  5. Legakis, 2004, Rapid decrease of leptin in middle-aged sedentary individuals after 20 minutes of vigorous exercise with early recovery after the termination of the test, J. Endocrinol. Investig., 27, 117, 10.1007/BF03346255 · DOI
  6. Olive, 2001, Differential effects of maximal- and moderate-intensity runs on plasma leptin in healthy trained subjects, Nutrition, 17, 365, 10.1016/S0899-9007(01)00522-6 · DOI
  7. Eriksson, 2008, Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin, Thromb. Res., 122, 701, 10.1016/j.thromres.2008.01.010 · DOI
  8. Bouassida, 2008, Review on leptin and adiponectin responses and adaptations to acute and chronic exercise, Br. J. Sports Med., 44, 620, 10.1136/bjsm.2008.046151 · DOI · Paper page
  9. Punyadeera, 2005, The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle, Eur. J. Endocrinol., 152, 427, 10.1530/eje.1.01872 · DOI
  10. Purge, 2004, Adiponectin is altered after maximal exercise in highly trained male rowers, Graefes Arch. Clin. Exp. Ophthalmol., 93, 502
  11. Purge, 2006, Adiponectin and stress hormone responses to maximal sculling after volume-extended training season in elite rowers, Metabolism, 55, 13, 10.1016/j.metabol.2005.06.020 · DOI
  12. Shiiya, 2002, Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion, J. Clin. Endocrinol. Metab., 87, 240, 10.1210/jcem.87.1.8129 · DOI · Paper page
  13. Godfrey, 2003, The Exercise-Induced Growth Hormone Response in Athletes, Sports Med., 33, 599, 10.2165/00007256-200333080-00005 · DOI · Paper page
  14. Purge, 2007, Plasma ghrelin is altered after maximal exercise in elite male rowers, Exp. Biol. Med., 232, 904
  15. Purge, 2009, Plasma Visfatin and Ghrelin Response to Prolonged Sculling in Competitive Male Rowers, Med. Sci. Sports Exerc., 41, 137, 10.1249/MSS.0b013e31818313e6 · DOI
  16. Toshinai, 2007, Acute Incremental Exercise Decreases Plasma Ghrelin Level in Healthy Men, Horm. Metab. Res., 39, 849, 10.1055/s-2007-991177 · DOI
  17. Vestergaard, 2007, The Ghrelin Response to Exercise before and after Growth Hormone Administration, J. Clin. Endocrinol. Metab., 92, 297, 10.1210/jc.2006-1435 · DOI
  18. Kraemer, 2004, Ghrelin and Other Glucoregulatory Hormone Responses to Eccentric and Concentric Muscle Contractions, Endocrine, 24, 93, 10.1385/ENDO:24:1:093 · DOI
  19. Rowlands, 2011, Oxidative stress, inflammation, and muscle soreness in an 894-km relay trail run, Graefes Arch. Clin. Exp. Ophthalmol., 112, 1839
  20. Smith, 2000, Cytokine hypothesis of overtraining: A physiological adaptation to excessive stress?, Med. Sci. Sports Exerc., 32, 317, 10.1097/00005768-200002000-00011 · DOI · Paper page
  21. Serrano, 2010, Antioxidant defence and inflammatory response in professional road cyclists during a 4-day competition, J. Sports Sci., 28, 1047, 10.1080/02640414.2010.484067 · DOI
  22. Nieman, 2012, Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity, J. Interf. Cytokine Res., 32, 12, 10.1089/jir.2011.0038 · DOI
  23. Nieman, 2014, Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling, Am. J. Physiol. Integr. Comp. Physiol., 307, R68, 10.1152/ajpregu.00092.2014 · DOI
  24. Lakhdar, 2013, Effects of intense cycling training on plasma leptin and adiponectin and its relation to insulin resistance, Neuro Endocrinol. Lett., 34, 229
  25. Pons, 2014, Changes in circulating cytokines and markers of muscle damage in elite cyclists during a multi-stage competition, Clin. Physiol. Funct. Imaging, 35, 351
  26. Pillon, 2013, Cross-talk between skeletal muscle and immune cells: Muscle-derived mediators and metabolic implications, Am. J. Physiol. Metab., 304, E453
  27. Plinta, 2011, The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin, adiponectin, visfatin, and ghrelin levels in young female handball and basketball players, J. Endocrinol. Investig., 35, 595
  28. Schmidt, 2004, Acute Exercise has no Effect on Ghrelin Plasma Concentrations, Horm. Metab. Res., 36, 174, 10.1055/s-2004-814342 · DOI
  29. Chatzinikolaou, 2014, The microcycle of inflammation and performance changes after a basketball match, J. Sports Sci., 32, 870, 10.1080/02640414.2013.865251 · DOI
  30. Souglis, 2015, Comparison of Inflammatory Responses and Muscle Damage Indices Following a Soccer, Basketball, Volleyball and Handball Game at an Elite Competitive Level, Res. Sports Med., 23, 59, 10.1080/15438627.2014.975814 · DOI
  31. Kraemer, 2002, Leptin and Exercise, Exp. Biol. Med., 227, 701, 10.1177/153537020222700903 · DOI
  32. Unal, 2005, Investigation of serum leptin levels in professional male football players and healthy sedentary males, Neuro Endocrinol. Lett., 26, 148
  33. Romagnoli, 2015, Changes in muscle damage, inflammation, and fatigue-related parameters in young elite soccer players after a match, J. Sports Med. Phys. Fit., 56, 1198
  34. Rosas, 2011, Functional Status and Inflammation after Preseason Training Program in Professional and Recreational Soccer Players: A Proteomic Approach, J. Sports Sci. Med., 10, 45
  35. Rebelo, 2008, Biochemical impact of a soccer match—Analysis of oxidative stress and muscle damage markers throughout recovery, Clin. Biochem., 41, 841, 10.1016/j.clinbiochem.2008.04.008 · DOI · Paper page
  36. Karamouzis, I., Karamouzis, M., Vrabas, I.S., Christoulas, K., Kyriazis, N., Giannoulis, E., and Mandroukas, K. (2002). The Effects of Marathon Swimming on Serum Leptin and Plasma Neuropeptide Y Levels. Clin. Chem. Lab. Med., 40. · DOI
  37. Knab, 2013, Effects of a Flavonoid-Rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics-Based Approach, Int. J. Sport Nutr. Exerc. Metab., 23, 150, 10.1123/ijsnem.23.2.150 · DOI
  38. Morgado, 2011, Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers, Graefes Arch. Clin. Exp. Ophthalmol., 112, 471
  39. Cheng, 2020, Intramuscular mechanisms of overtraining, Redox Biol., 35, 101480, 10.1016/j.redox.2020.101480 · DOI
  40. Gorini, 2018, Irreversible plasma and muscle protein oxidation and physical exercise, Free. Radic. Res., 53, 126, 10.1080/10715762.2018.1542141 · DOI
  41. Lauridsen, 2019, From oxidative stress to inflammation: Redox balance and immune system, Poult. Sci., 98, 4240, 10.3382/ps/pey407 · DOI · Paper page
  42. Cazzola, 2003, Biochemical assessments of oxidative stress, erythrocyte membrane fluidity and antioxidant status in professional soccer players and sedentary controls, Eur. J. Clin. Investig., 33, 924, 10.1046/j.1365-2362.2003.01227.x · DOI
  43. Diboun, 2018, A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines, Sports Med. Open, 4, 1
  44. Balog, 2006, The influence of season on oxidant–antioxidant status in trained and sedentary subjects, Life Sci., 78, 1441, 10.1016/j.lfs.2005.07.039 · DOI
  45. Vucic, 2015, Redox balance in elite female athletes: Differences based on sport types, J. Sports Med. Phys. Fit., 56, 1
  46. Gamberi, 2019, Postactivation potentiation improves athletic performance without affecting plasma oxidative level, J. Sports Med. Phys. Fit., 59, 975
  47. Feriche, 2018, Oxidative stress in elite athletes training at moderate altitude and at sea level, Eur. J. Sport Sci., 18, 832, 10.1080/17461391.2018.1453550 · DOI
  48. McGinnis, 2014, Acute Hypoxia and Exercise-Induced Blood Oxidative Stress, Int. J. Sport Nutr. Exerc. Metab., 24, 684, 10.1123/ijsnem.2013-0188 · DOI
  49. Wadley, 2017, Heightened Exercise-Induced Oxidative Stress at Simulated Moderate Level Altitude vs. Sea Level in Trained Cyclists, Int. J. Sport Nutr. Exerc. Metab., 27, 97, 10.1123/ijsnem.2015-0345 · DOI
  50. Guidi, 2011, Plasma proteincarbonylation and physical exercise, Mol. BioSyst., 7, 640, 10.1039/C0MB00106F · DOI
  51. Yasuda, 2015, Effects of repeated bouts of long-duration endurance exercise on muscle and urinary levels of 8-hydroxy-2′-deoxyguanosine in moderately trained cyclists, J. Sports Sci., 33, 1692, 10.1080/02640414.2015.1004637 · DOI
  52. Lekhi, 2007, Influence of exercise on oxidant stress products in elite Indian cyclists, Br. J. Sports Med., 41, 691, 10.1136/bjsm.2007.037663 · DOI
  53. Shing, 2007, The effect of consecutive days of exercise on markers of oxidative stress, Appl. Physiol. Nutr. Metab., 32, 677, 10.1139/H07-051 · DOI
  54. Olcina, 2010, Effect of different exercise intensities on oxidative stress markers and antioxidant response in trained cyclists, J. Sports Med. Phys. Fit., 50, 93
  55. Zabala, 2014, Redox status and antioxidant response in professional cyclists during training, Eur. J. Sport Sci., 14, 830, 10.1080/17461391.2014.915345 · DOI
  56. Maleki, 2014, The Effects of 16 Weeks of Intensive Cycling Training on Seminal Oxidants and Antioxidants in Male Road Cyclists, Clin. J. Sport Med., 24, 302, 10.1097/JSM.0000000000000051 · DOI
  57. Kalinski, 2002, Anaerobic power characteristics of elite athletes in national level team-sport games, Eur. J. Sport Sci., 2, 1, 10.1080/17461390200072303 · DOI
  58. Terrados, 2003, Blood lactate and heart rate during national and international women’s basketball, J. Sports Med. Phys. Fit., 43, 432
  59. Tessitore, 2006, Aerobic-Anaerobic Profiles, Heart Rate and Match Analysis in Old Basketball Players, Gerontol., 52, 214, 10.1159/000093653 · DOI
  60. Castagna, 2010, Activity Profile and Physiological Requirements of Junior Elite Basketball Players in Relation to Aerobic-Anaerobic Fitness, J. Strength Cond. Res., 24, 2330, 10.1519/JSC.0b013e3181e381c1 · DOI · Paper page
  61. Spanidis, 2015, Variations in oxidative stress markers in elite basketball players at the beginning and end of a season, Exp. Ther. Med., 11, 147, 10.3892/etm.2015.2843 · DOI
  62. Yilmaz, 2007, Biochemical assessments of retinol, α-tocopherol, pyridoxal—5-phosphate oxidative stress index and total antioxidant status in adolescent professional basketball players and sedentary controls, Int. J. Adolesc. Med. Heal., 19, 177
  63. Valjevac, 2014, Oxidative stress status in elite athletes engaged in different sport disciplines, Bosn. J. Basic Med Sci., 14, 56, 10.17305/bjbms.2014.2262 · DOI
  64. Perrea, 2013, Comparison of the Short-Term Oxidative Stress Response in National League Basketball and Soccer Adolescent Athletes, Angiology, 65, 624, 10.1177/0003319713497991 · DOI
  65. Farney, 2012, Absence of blood oxidative stress in trained men following strenuous exercise, Med. Sci. Sports Exerc., 44, 1855, 10.1249/MSS.0b013e3182592575 · DOI
  66. Zlatkovic, 2011, The effects of progressive exercise on cardiovascular function in elite athletes: Focus on oxidative stress, Acta Physiol. Hung., 98, 51, 10.1556/APhysiol.98.2011.1.7 · DOI
  67. Fatouros, 2010, Time-Course of Changes in Oxidative Stress and Antioxidant Status Responses Following a Soccer Game, J. Strength Cond. Res., 24, 3278, 10.1519/JSC.0b013e3181b60444 · DOI
  68. Gravina, 2012, Influence of nutrient intake on antioxidant capacity, muscle damage and white blood cell count in female soccer players, J. Int. Soc. Sports Nutr., 9, 32, 10.1186/1550-2783-9-32 · DOI
  69. Gravina, 2011, Metabolic impact of a soccer match on female players, J. Sports Sci., 29, 1345, 10.1080/02640414.2011.597420 · DOI
  70. Zivkovic, 2013, Alteration in basal redox state of young male soccer players after a six-month training programme, Acta Physiol. Hung., 100, 64, 10.1556/APhysiol.100.2013.1.6 · DOI
  71. Groussard, 2016, Redox Status of Professional Soccer Players is Influenced by Training Load Throughout a Season, Int. J. Sports Med., 37, 680, 10.1055/s-0035-1565199 · DOI
  72. Deminice, 2010, Oxidative stress biomarkers response to high intensity interval training and relation to performance in competitive swimmers, J. Sports Med. Phys. Fit., 50, 356
  73. Lubkowska, 2013, Winter-swimming as a building-up body resistance factor inducing adaptive changes in the oxidant/antioxidant status, Scand. J. Clin. Lab. Investig., 73, 315, 10.3109/00365513.2013.773594 · DOI
  74. Kouretas, 2011, Blood Oxidative Stress Markers After Ultramarathon Swimming, J. Strength Cond. Res., 25, 805, 10.1519/JSC.0b013e3181d0b109 · DOI
  75. Kabasakalis, 2014, Effects of endurance and high-intensity swimming exercise on the redox status of adolescent male and female swimmers, J. Sports Sci., 32, 747, 10.1080/02640414.2013.850595 · DOI

Cited by

Metadata

Authors
Luti, S., Modesti, A., & Modesti, P. A.
Venue
Antioxidants
Publisher
MDPI AG
Published
2020-10-30
Volume
9
Issue
11
Pages
1065
ISSN
2076-3921
DOI
10.3390/antiox9111065
Cited by
31
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.