The Administration of Probiotics against Hypercholesterolemia: A Systematic Review
Open accessAbstract
Hypercholesterolemia is a key factor in the progression of atherosclerosis and cardiovascular disease (CVD). CVD is a significant public health concern with a high death rate. Some of the main factors linked to CVD include genetics and lifestyle. Dyslipidemia has been one of the factors related to the onset of several CVD-related diseases. Several clinicopathological studies have shown a correlation between high cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-c), and CVD development. Probiotics have received a lot of attention for various beneficial effects, especially their ability to reduce blood cholesterol in humans. Probiotics were shown in several investigations to affect hypercholesterolemia by influencing cholesterol biosynthesis. The current review focuses on the human dietary interventions with probiotics and their effects on CVD risk factors and hypercholesterolemia. The outcomes are debatable and consider various parameters such as probiotic strain, dosing frequency, therapeutic response, dietary changes, and so forth. As a result, probiotics have the propensity to become dietary supplements in moderate/severe hypercholesterolemic patients, which significantly reduces the CVD risk.
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Probiotics reduce blood cholesterol levels.
“In addition to modulating the immune system, the positive health effects of taking probiotics include: the improvement of lactose tolerance and digestion [199,205], the prevention and treatment of gastrointestinal infections [206], the prevention of colorectal cancer [203,207], reduction in blood cholesterol levels [208,209,210], and the improvement of mental health via the gut-brain axis [211].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [209]
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References 74 · Cited by 20
- Authors
- Sivamaruthi, B. S., Bharathi, M., Kesika, P., Suganthy, N., & Chaiyasut, C.
- Affiliations
- Chiang Mai University (TH)
- Alagappa University (IN)
- Corresponding author
- Chaiyasut, Chaiyavat
- ORCID
- Venue
- Applied Sciences
- Publisher
- MDPI AG
- Published
- 2021-07-27
- Volume
- 11
- Issue
- 15
- Pages
- 6913
- ISSN
- 2076-3417 (ISSN-L)
- OpenAlex
- W3186632331
- Cited by
- 20
- References
- 74
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 3
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Applied Sciences (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chiang Mai University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- probiotics, hypercholesterolemia, cardiovascular disease, LDL cholesterol, dyslipidemia, cholesterol biosynthesis, dietary intervention, probiotic strains, cardiovascular risk factors, dietary supplements
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