The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Platinum Resistance in Ovarian Cancer: Role of DNA Repair
Open accessAbstract
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs.
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1 retracted
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Integrated genomic analyses of ovarian carcinoma
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Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature
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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
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Cited by
Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway
Tossetta, G., & Marzioni, D. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106365 · Cited by 115
Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer
Li, J., Hu, H., He, J., Hu, Y., Liu, M., Cao, B., Chen, D., Ye, X., Zhang, J., Zhang, Z., et al. (2024) · Translational Oncology · doi:10.1016/j.tranon.2023.101825 · Cited by 4
Wei, R., Dai, H., Zhang, J., Shih, D. J. H., Liang, Y., Xiao, P., McGrail, D. J., & Lin, S.-Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095008 · Cited by 4
Metadata
- Authors
- Damia, G., & Broggini, M.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2019-01-20
- Volume
- 11
- Issue
- 1
- Pages
- 119
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W2908832432
- Cited by
- 298
- References
- 116
- FWCI
- 36.22
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
