YAP/TAZ signalling in colorectal cancer: lessons from consensus molecular subtypes
Open accessAbstract
Recent advance in the characterization of the heterogeneity of colorectal cancer has led to the definition of a consensus molecular classification within four CMS subgroups, each associated with specific molecular and clinical features. Investigating the signalling pathways that drive colorectal cancer progression in relation to the CMS classification may help design therapeutic strategies tailored for each CMS subtype. The two main effectors of the Hippo pathway YAP and its paralogue TAZ have been intensively scrutinized for their contribution to colon carcinogenesis. Here, we review the knowledge of YAP/TAZ implication in colorectal cancer from the perspective of the CMS framework. We identify gaps in our current understanding and delineate research avenues for future work.
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Activation of YAP and/or TAZ is a cardinal trait of CMS4 colorectal cancer, similar to that of TGFβ.
“Activation of YAP and/or TAZ appears to represent a cardinal trait of CMS4 colorectal cancer, similar to that of TGFβ (40).”
From Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine (2024) · cites this paper as [40]
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References 106 · Cited by 40
- Authors
- Mouillet-Richard, S., & Laurent-Puig, P.
- Affiliations
- Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2020-10-28
- Volume
- 12
- Issue
- 11
- Pages
- 3160
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC7692643
- OpenAlex
- W3095524575
- Cited by
- 40
- References
- 106
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Association pour la Recherche sur le Cancer (PJA 20171206220)
- cancéropôle Ile de France (2016-1-EMERG-36-UP 5-1)
- SIRIC CARPEM (NA)
- Institut National de la Santé et de la Recherche Médicale (U1138)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- YAP, TAZ, Hippo signaling pathway, colorectal cancer, consensus molecular subtypes, colon carcinogenesis, tumor heterogeneity, targeted therapy
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