Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy
Open accessAbstract
Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.
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Exosomes loaded with mRNA drugs may be passively transported throughout the body or targeted through surface engineering.
“Exosomes loaded with mRNA drugs may be passively transported throughout the body or targeted through surface engineering [87].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [87]
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References 181 · Cited by 152
- Authors
- Kim, H., Jang, H., Cho, H., Choi, J., Hwang, K. Y., Choi, Y., Kim, S. H., & Yang, Y.
- Affiliations
- Center for Theragnosis, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea
- Korea Institute of Science and Technology (KR)
- Korea University (KR)
- Corresponding author
- Kim, Sun Hwa
- Yang, Yoosoo
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2021-09-02
- Volume
- 13
- Issue
- 17
- Pages
- 4435
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC8430743
- OpenAlex
- W3196775896
- Cited by
- 152
- References
- 181
- Citations by year
- 2026: 22 · 2025: 48 · 2024: 31 · 2023: 30 · 2022: 21
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (NRF-2019R1A2C2010408, NRF-2020H1D3A1A02081401)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- exosomes, extracellular vesicles, drug delivery, cancer therapy, targeted delivery, nucleic acids, chemotherapeutic drugs, protein delivery, biocompatibility, immunogenicity
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