The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review
Open accessAbstract
Cancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the range of effective treatments. Terpenoids, a large group of secondary metabolites, are derived from plant sources and are composed of several isoprene units. The high diversity of terpenoids has drawn attention to their potential anticancer and pharmacological activities. Some terpenoids exhibit an anticancer effect by triggering various stages of cancer progression, for example, suppressing the early stage of tumorigenesis via induction of cell cycle arrest, inhibiting cancer cell differentiation and activating apoptosis. At the late stage of cancer development, certain terpenoids are able to inhibit angiogenesis and metastasis via modulation of different intracellular signaling pathways. Significant progress in the identification of the mechanism of action and signaling pathways through which terpenoids exert their anticancer effects has been highlighted. Hence, in this review, the anticancer activities of twenty-five terpenoids are discussed in detail. In addition, this review provides insights on the current clinical trials and future directions towards the development of certain terpenoids as potential anticancer agents.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
3 retracted
Ravindran, J., Nair, H. B. B., Sung, B., Prasad, S., TEKMAL, R. R., & Aggarwal, B. B. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.01.023 · Cited by 138
RetractedPrasad, S., Nigam, N., Kalra, N., & Shukla, Y. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20442 · Cited by 52
RetractedMoradzadeh, M., Ghorbani, A., Erfanian, S., Mohaddes, S. T., Rahimi, H., Karimiani, E. G., Mashkani, B., Chiang, S., El‐Khamisy, S. F., Tabarraei, A., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27489 · Cited by 15
RetractedSung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743
Targeting mitochondria for cancer therapy
Fulda, S., Galluzzi, L., & Kroemer, G. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3137 · Cited by 1,629
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis
Roos, W. P., & Kaina, B. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.01.007 · Cited by 879
Calcium and cancer: targeting Ca2+ transport
Monteith, G. R., McAndrew, D., Faddy, H. M., & Roberts-Thomson, S. J. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2171 · Cited by 676
Metadata
- Authors
- Kamran, S., Sinniah, A., Abdulghani, M. A. M., & Alshawsh, M. A.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2022-02-22
- Volume
- 14
- Issue
- 5
- Pages
- 1100
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W4214735603
- Cited by
- 259
- References
- 204
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. https://app.cochat.ai/papers/10.3390/cancers14051100
- The paper
- Kamran, S., Sinniah, A., Abdulghani, M. A. M., & Alshawsh, M. A. (2022). Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. Cancers. https://doi.org/10.3390/cancers14051100
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
