A Review on Annona muricata and Its Anticancer Activity
Open accessAbstract
The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. This review focuses on the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract in downregulating anti-apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Therefore, the active phytochemicals identified in A. muricata have the potential to be employed as a promising anti-cancer agent.
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Alkaloids such as anonaine, glaucine, and reticuline have demonstrated antimicrobial and anticancer properties.
“Alkaloids such as anonaine, glaucine, and reticuline have demonstrated antimicrobial and anticancer properties [1,10,11].”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [11]
Section 3.1 (page unavailable) identifies anonaine and reticuline as alkaloids and reports cancer-cell testing of alkaloids, though it specifically names xylopine and isocoreximine—not anonaine or reticuline—as showing anticancer activity. The cited passages do not establish antimicrobial activity for the named compounds or mention glaucine. (LLM, conf=0.76)
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References 180 · Cited by 91
Research works printed but not linked: 3
- [16]Urbi Z. Hossain M.S. Rahman K.M.H. Zayed T.M. Grape: A Medicinal Fruit Species in the Holy Qur’an and Its Ethnomedicinal Importance World Appl. Sci. J. 2014 30 253 265 10.5829/idosi.wasj.2014.30.03.81114 · DOI
- [30]Mishra S. Ahmad S. Kumar N. Sharma B.K. Annona muricata (the Cancer Killer): A Review Glob. J. Pharma. Res. 2013 2 1613 1618
- [43]Correa-Gordillo J. Ortiz J. Sánchez-Mejía M. Pachón H. Antioxidant Activity in Guanabana (Annona muricata L.): A Literature Review Lat. Am. Caribb. Bull. Med. Aromat. Plants 2012 11 111 126
- Authors
- Ilango, S., Sahoo, D. K., Paital, B., Kathirvel, K., Gabriel, J. I., Subramaniam, K., Jayachandran, P., Dash, R. K., Hati, A. K., Behera, T. R., Mishra, P., & Nirmaladevi, R.
- Affiliations
- Avinashilingam University (IN)
- Iowa State University (US)
- Odisha University of Agriculture and Technology (IN)
- Dr Abhin Chandra Homeopathic Medical College & Hospital, Bhubaneswar 751001, India
- Sriram Chandra Bhanja Medical College Hospital (IN)
- Corresponding author
- Paital, Biswaranjan
- Nirmaladevi, Ramalingam
- ORCID
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2022-09-19
- Volume
- 14
- Issue
- 18
- Pages
- 4539
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC9497149
- OpenAlex
- W4296525262
- Cited by
- 91
- References
- 180
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 31 · 2023: 17 · 2022: 1
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- SERB, DST, Govt. of India, New Delhi (ECR/2016/001984)
- Department of Biotechnology, DST, Government of Odisha, Bhubaneswar (ECR/2016/001984)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Traditional and Medicinal Uses of Annonaceae
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- Annona muricata, anticancer activity, medicinal plants, phytochemicals, acetogenins, alkaloids, phenols, apoptosis, cell proliferation, metastasis, cell invasion, anti-apoptotic genes, ethnomedicine, Annonaceae
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