The DOI matches its Crossref record; 217 of the 217 references it cites were found in a registry or an index.
Current Status and Future Prospects for Esophageal Cancer
Open accessAbstract
Esophageal cancer (EC) is the ninth most common cancer and the sixth leading cause of cancer deaths worldwide. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are the two main histological subtypes with distinct epidemiological and clinical features. While the global incidence of ESCC is declining, the incidence of EAC is increasing in many countries. Decades of epidemiologic research have identified distinct environmental exposures for ESCC and EAC subtypes. Recent advances in understanding the genomic aspects of EC have advanced our understanding of EC causes and led to using specific genomic alterations in EC tumors as biomarkers for early diagnosis, treatment, and prognosis of this cancer. Nevertheless, the prognosis of EC is still poor, with a five-year survival rate of less than 20%. Currently, there are significant challenges for early detection and secondary prevention for both ESCC and EAC subtypes, but Cytosponge™ is shifting this position for EAC. Primary prevention remains the preferred strategy for reducing the global burden of EC. In this review, we will summarize recent advances, current status, and future prospects of the studies related to epidemiology, time trends, environmental risk factors, prevention, early diagnosis, and treatment for both EC subtypes.
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Cited by
Global trends in esophageal cancer mortality with predictions to 2025, and in incidence by histotype
Santucci, C., Mignozzi, S., Malvezzi, M., Collatuzzo, G., Levi, F., La Vecchia, C., & Negri, E. (2023) · Cancer Epidemiology · doi:10.1016/j.canep.2023.102486 · Cited by 42
Metadata
- Authors
- Sheikh, M., Roshandel, G., McCormack, V., & Malekzadeh, R.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2023-01-26
- Volume
- 15
- Issue
- 3
- Pages
- 765
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W4318203608
- Cited by
- 270
- References
- 217
- FWCI
- 64.16
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
