Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
Mithaiwala, Mustafa N., Santana-Coelho, Danielle, Porter, Grace A., O’Connor, Jason C.·2021·Cells
Cites (303)
Items 201–302 of 302
- Xanthurenic acid distribution, transport, accumulation and release in the rat brainSerge Gobaille, Véronique Kemmel, Daniel Brumaru, Christophe Dugave, Dominique Aunis, Michel Maître · 2008 · Journal of Neurochemistry
- Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controlsCarl M. Sellgren, Jessica Gracias, Oscar Jungholm, Roy H. Perlis, Göran Engberg, Lilly Schwieler, Mikael Landén, Sophie Erhardt · 2019 · Translational Psychiatry
- Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s diseasePratishtha Chatterjee, Henrik Zetterberg, Kathryn G. Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas James Ashton, Abdul Hye, Steve Pedrini, Hamid Reza Sohrabi, Tejal M. Shah et al. · 2019 · Journal of Neuroinflammation
- The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxineYu Sun, Wayne Curtis Drevets, Gustavo Turecki, Qingqin S. Li · 2020 · Brain Behavior and Immunity
- Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticityAmira Latif‐Hernandez, Disha Shah, Tariq Ahmed, Adrian C. Lo, Zsuzsanna Callaerts‐Vegh, Annemie Van der Linden, Detlef Balschun, Rudi D’Hooge · 2016 · Scientific Reports
- Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markersFarzi, Aitak, Reichmann, Florian, Meinitzer, Andreas, Mayerhofer, Raphaela, Jain, Piyush, Hassan, Ahmed M., Fröhlich, Esther E., Wagner, Karin, Painsipp, Evelin, Rinner, Beate et al. · 2015 · Brain Behavior and Immunity
- The impact of electroconvulsive therapy on the tryptophan–kynurenine metabolic pathwaySinan Gülöksüz, Baer M.G. Arts, Sharon Walter, Marjan Drukker, Laura Rodriguez, Aye-Mu Myint, Markus Schwarz, Rudolf Ponds, Jim van Os, Günter Kenis et al. · 2015 · Brain Behavior and Immunity
- Systematic Review on the Involvement of the Kynurenine Pathway in Stroke: Pre-clinical and Clinical EvidenceGabriela Delevati Colpo, Venugopal Reddy Venna, Louise D. McCullough, Antônio Lúcio Teixeira · 2019 · Frontiers in Neurology
- Microbial regulation of hippocampal miRNA expression: implications for transcription of kynurenine pathway enzymesMoloney, Gerard M., O’Leary, Olivia F., Salvo-Romero, Eloisa, Desbonnet, Lieve, Shanahan, Fergus, Dinan, Timothy G., Clarke, Gerard, Cryan, John F. · 2017 · Behavioural Brain Research
- Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cellsTakako Yamamoto, Kunitada Hatabayashi, Mao Arita, Nobuyuki Yajima, Chiemi Takenaka, Takashi Suzuki, Masatoshi Takahashi, Yasuhiro Oshima, Keisuke Hara, Kenichi Kagawa et al. · 2019 · Science Signaling
- Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathiesPetra Majerová, Alena Michalicová, Martin Cente, Jozef Hanes, Jozef Vegh, Ágnes Kittel, Nina Kosikova, Viera Cigánková, Sandra Mihaljević, Santosh Jadhav et al. · 2019 · PLoS ONE
- Cognitive Dysfunction Precedes the Onset of Motor Symptoms in the MitoPark Mouse Model of Parkinson’s DiseaseXiuhua Li, Laney Redus, Cang Chen, Paul Anthony Martinez, Randy Strong, Senlin Li, Jason C. O’Connor · 2013 · PLoS ONE
- The kynurenine pathway in major depression: Haplotype analysis of three related functional candidate genesClaes, Stephan, Myint, Aye-Mu, Domschke, Katharina, Del-Favero, Jurgen, Entrich, Kathrin, Engelborghs, Sebastiaan, De Deyn, Peter, Mueller, Norbert, Baune, Bernhard, Rothermundt, Matthias · 2011 · Psychiatry Research
- Relevance of Alternative Routes of Kynurenic Acid Production in the BrainL. A. Ramos-Chávez, R. Lugo Huitrón, D. G. Esquivel, B. Pineda, C. Ríos, D. Silva-Adaya, L. Sánchez-Chapul, G. Roldán-Roldán, V. Pérez de la Cruz · 2018 · Oxidative Medicine and Cellular Longevity
- Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemiaLevente Gellért, János Fuzik, Anikó Göblös, Kitti Sárközi, Máté Marosi, Zsolt Kis, Tamás Farkas, István Szatmári, Ferenc Fülöp, László Vécsei et al. · 2011 · European Journal of Pharmacology
- Delayed Increases in Regional Brain Quinolinic Acid Follow Transient Ischemia in the GerbilMelvyn P. Heyes, Thaddeus S. Nowak · 1990 · Journal of Cerebral Blood Flow & Metabolism
- Modulation of Hippocampal Synaptic Transmission by the Kynurenine Pathway Member Xanthurenic Acid and Other VGLUT InhibitorsStuart A. Neale, Caroline S. Copeland, Victor N. Uebele, FIONA J. THOMSON, T.E. Salt · 2013 · Neuropsychopharmacology
- The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's diseaseVahri Beaumont, Ladislav Mrzljak, Ulrike Dijkman, Robert Freije, Mariette Heins, Arash Rassoulpour, Geoffrey C. Tombaugh, Simon Gelman, Amyaouch Bradaïa, Esther Steidl et al. · 2016 · Experimental Neurology
- Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of RatsDavid Martín‐Hernández, Hiram Tendilla‐Beltrán, José L. M. Madrigal, Borja García‐Bueno, Juan Carlos Leza, Javier R. Caso · 2018 · Molecular Neurobiology
- A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolitesShaowei Zhang, Michiyo Sakuma, Girdhar Singh Deora, Colin Levy, Alex D. Klausing, Carlo Breda, Kevin D. Read, Chris D. Edlin, Benjamin P. Ross, Marina Wright Muelas et al. · 2019 · Communications Biology
- 3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr−/− miceMartin Berg, Konstantinos A. Polyzos, Hanna E. Agardh, Roland Baumgartner, María J. Forteza, Ilona Kareinen, Anton Gisterå, Gerhard Böttcher, Eva Hurt‐Camejo, Göran K. Hansson et al. · 2019 · Cardiovascular Research
- Role of astrocytes in memory and psychiatric disordersRodrigo Moraga‐Amaro, Juan Manuel Jerez-Baraona, Felipe Simón, Jimmy Stehberg · 2014 · Journal of Physiology-Paris
- Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stressLucia García‐Lara, Francisca Pérez‐Severiano, Dinora F. González‐Esquivel, Guillermo Elizondo, José Segovia · 2015 · Journal of Neuroscience Research
- Regulation of proinflammatory monocyte activation by the kynurenine–AhR axis underlies immunometabolic control of depressive behavior in miceXiaojie Zang, Xiao Zheng, Yuanlong Hou, Miaomiao Hu, Hong Wang, Xiaoqiang Bao, Fang Zhou, Guangji Wang, Haiping Hao · 2017 · The FASEB Journal
- Actions of Xanthurenic Acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamusCaroline S. Copeland, Stuart A. Neale, T.E. Salt · 2012 · Neuropharmacology
- The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonismJ.F. Martí-Massó, Alberto Bergareche, Vladimir Makarov, Javier Ruiz‐Martínez, Ana Gorostidi, Adolfo López de Munaín, Juan José Poza, Pasquale Striano, Joseph D. Buxbaum, Coro Paisán‐Ruiz · 2013 · Journal of Molecular Medicine
- Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological EffectsKorrapati V. Sathyasaikumar, Margarita A. Tararina, Hui‐Qiu Wu, Stuart A. Neale, Filippo Weisz, T.E. Salt, Robert M. Schwarcz · 2017 · Neuroscience
- Kynurenine pathway metabolism and the neurobiology of treatment-resistant depression: Comparison of multiple ketamine infusions and electroconvulsive therapyAndrew P. Allen, Maura Naughton, Joshua L. Dowling, Annabel E. L. Walsh, R. O'Shea, George Shorten, Lucinda V. Scott, Declan M. McLoughlin, John F. Cryan, Gerard A. Clarke et al. · 2018 · Journal of Psychiatric Research
- Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicityAbdur Rahman, M.S. Rama Rao, Khalid M. Khan · 2018 · Journal of Neuroinflammation
- Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in miceFrancesco Fazio, Cristina Zappulla, Serena Notartomaso, Carla Letizia Busceti, Alban Bessede, Pamela Scarselli, Carmine Vacca, Marco Gargaro, Claudia Volpi, M. Allegrucci et al. · 2014 · Neuropharmacology
- Microglia activation contributes to quinolinic acid-induced neuronal excitotoxicity through TNF-αFeng, Wei, Wang, Yan, Liu, Zi-Qi, Zhang, Xuan, Han, Rong, Miao, You-Zhu, Qin, Zheng-Hong · 2017 · Apoptosis
- A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of ratsAjeesh Koshy Cherian, Howard J. Gritton, David E. Johnson, Damon A. Young, Rouba Kozak, Martin F. Sarter · 2014 · Neuropharmacology
- Antiviral, cytotoxic and apoptotic activities of picolinic acid on human immunodeficiency virus-1 and human herpes simplex virus-2 infected cells.J. A. Fernandez‐Pol, Dennis J. Klos, P D Hamilton · 2002 · PubMed
- Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophreniaIkwunga Wonodi, Robert P. McMahon, Nithin Krishna, Braxton D. Mitchell, Judy Liu, Matthew Glassman, Liyi Elliot Hong, James M. Gold · 2014 · Schizophrenia Research
- Kynurenic Acid Restores Nrf2 Levels and Prevents Quinolinic Acid-Induced Toxicity in Rat Striatal SlicesFernanda Silva Ferreira, Helena Biasibetti, Paula Pierozan, Felipe Schmitz, Carolina Gessinger Bertó, Caroline A. Prezzi, Vanusa Manfredini, Ângela Terezinha de Souza Wyse · 2018 · Molecular Neurobiology
- Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapyKaren M. Ryan, Kelly Ann Allers, Declan M. McLoughlin, Andrew Harkin · 2019 · Brain Behavior and Immunity
- Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolonesShanshan Cai, Katsumasa Sato, Toshiaki Shimizu, Seiko Yamabe, Miho Hiraki, Chiaki Sano, Haruaki Tomioka · 2005 · Journal of Antimicrobial Chemotherapy
- Kynurenic Acid Levels in Cerebrospinal Fluid from Patients with Alzheimer's Disease or Dementia with Lewy BodiesMalin Wennström, Henrietta M. Nielsen, Funda Orhan, Elisabet Londos, Lennart Minthon, Sophie Erhardt · 2014 · International Journal of Tryptophan Research
- Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression‐like behaviorA. Eskelund, Yan Li, D. Budac, H. Müller, M. Gulinello, C. Sánchez, G. Wegener · 2017 · Journal of Neurochemistry
- The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophreniaGislaine Z. Réus, Indianara Reynaud Toreti Becker, Giselli Scaini, Fabricia Cardoso Petronilho, Jean Pierre Oses, Rima F Kaddurah-Daouk, Luciane Bisognin Ceretta, Alexandra Ioppi Zugno, Felipe Dal‐Pizzol, João Quevedo et al. · 2017 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampusFlavio Moroni, Andrea Cozzi, R. Carpendo, Gianluca Cipriani, O. Veneroni, Emanuela Izzo · 2005 · Neuropharmacology
- Association study between kynurenine 3‐monooxygenase gene and schizophrenia in the Japanese populationN. Aoyama, Nagahide Takahashi, Susumu Saito, N. Maeno, R. Ishihara, Xiaohui Ji, Hideki Miura, Masashi Ikeda, Taroh Suzuki, Tsuyoshi Kitajima et al. · 2006 · Genes Brain & Behavior
- The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatumAna Laura Colín-González, Marisol Maya-López, José Pedraza‐Chaverrí, Syed F. Ali, Anahí Chavarría, Abel Santamarı́a · 2014 · Brain Research
- Common genetic variation in the indoleamine-2,3-dioxygenase genes and antidepressant treatment outcome in major depressive disorderJessica A Cutler, Augustus John Rush, Francis J. McMahon, Gonzalo Laje · 2012 · Journal of Psychopharmacology
- Regulation of GABAergic Inputs to CA1 Pyramidal Neurons by Nicotinic Receptors and Kynurenic AcidJyotirmoy Banerjee, Manickavasagom Alkondon, Edna F. R. Pereira, Edson Xavier Albuquerque · 2012 · Journal of Pharmacology and Experimental Therapeutics
- Biochemical identification and crystal structure of kynurenine formamidase fromDrosophila melanogasterQian Han, Howard H. Robinson, Jianyong Li · 2012 · Biochemical Journal
- Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?Francesco Fazio, Albino Carrizzo, Luana Lionetto, Antonio Damato, Luca Capocci, Mariateresa Ambrosio, Giuseppe Battaglia, Valeria Bruno, Michele Madonna, Maurizio Simmaco et al. · 2017 · Frontiers in Pharmacology
- Role of human brain microvascular endothelial cells during central nervous system infectionRüdiger Adam, Daniel Rüßing, Ortwin Adams, Aziz Ailyati, Kwang Sik Kim, Horst Schroten, Walter Däubener · 2005 · Thrombosis and Haemostasis
- Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortexDavid M. Bortz, Hui‐Qiu Wu, Robert M. Schwarcz, John P. Bruno · 2017 · Neuropharmacology
- Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndromePaul J. Kennedy, Andrew P. Allen, Ann O’Neill, Eamonn M.M. Quigley, John F. Cryan, Timothy G. Dinan, Gerard A. Clarke · 2014 · Psychopharmacology
- Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with FluoxetineA. Laugeray, J. Launay, J. Callebert, O. Mutlu, G. Guillemin, C. Belzung, P. Barone · 2016 · PLoS ONE
- 3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Enhance the Toxicity Induced by Copper in Rat Astrocyte CultureD. Ramírez-Ortega, Alelí Ramiro-Salazar, D. González-Esquivel, C. Ríos, B. Pineda, V. Pérez de la Cruz · 2017 · Oxidative Medicine and Cellular Longevity
- Inhibition of the kynurenine pathway protects against reactive microglial‐associated reductions in the complexity of primary cortical neuronsK. O'Farrell, E. Fagan, T. Connor, A. Harkin · 2017 · European Journal of Pharmacology
- The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activationJohanna Prodinger, Lisa J Loacker, Ralf L. J. Schmidt, Franz Ratzinger, Georg Greiner, Nadine Witzeneder, Gregor Hoermann, Sabrina Jutz, Winfried Franz Pickl, Peter Steinberger et al. · 2015 · Journal of Leukocyte Biology
- The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain.G. Mazarei, David P. Budac, G. Lu, Hong J. Lee, Thomas Möller, B. R. Leavitt · 2013 · Experimental Neurology
- Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature MortalityDavid W. Donley, Andrew R. Olson, Merl F. Raisbeck, Jonathan H. Fox, Jason P. Gigley · 2016 · PLoS ONE
- Pharmacologic Induction of Endotoxin Tolerance in Dendritic Cells by L-KynurenineGiorgia Manni, Giada Mondanelli, Giulia Scalisi, Maria Teresa Pallotta, Dario Nardi, Eleonora Padiglioni, Rita Romani, Vincenzo Nicola Talesa, Paolo Puccetti, Francesca Fallarino et al. · 2020 · Frontiers in Immunology
- Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortexStuart A. Neale, Caroline S. Copeland, T.E. Salt · 2013 · Neurochemistry International
- Quinolinic acid induces disrupts cytoskeletal homeostasis in striatal neurons. Protective role of astrocyte–neuron interactionPaula Pierozan, Fernanda da Silva Ferreira, Bárbara Ortiz de Lima, Regina Pessoa‐Pureur · 2014 · Journal of Neuroscience Research
- The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expressionSara Hemmati, Mohammad Amin Sadeghi, Razieh Mohammad Jafari, Hasan Yousefi‐Manesh, Ahmad Reza Dehpour · 2019 · Journal of Neuroinflammation
- NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.Claudia Backhaus, Hafizur Rahman, Sebastian Scheffler, H. Laatsch, R. Hardeland · 2008 · Nitric oxide
- In Situ Produced 7-Chlorokynurenate Provides Protection against Quinolinate- and Malonate-Induced Neurotoxicity in the Rat StriatumPaolo Guidetti, Hui‐Qiu Wu, Robert M. Schwarcz · 2000 · Experimental Neurology
- ?-4-?hlorokynurenine Attenuates Kainate-Induced Seizures and Lesions in the RatHui-Qui Wu · 2002 · Experimental Neurology
- Randomized, double-blind, placebo-controlled, dose-escalation study: Investigation of the safety, pharmacokinetics, and antihyperalgesic activity of L-4-chlorokynurenine in healthy volunteersMark S. Wallace, Alexander White, Kathy A. Grako, Randal Lane, Allen Cato, H. Ralph Snodgrass · 2017 · Scandinavian Journal of Pain
- Kynurenic acid accumulation underlies learning and memory impairment associated with agingMihir Vohra, George A. Lemieux, Lin Lin, Kaveh Ashrafi · 2018 · Genes & Development
- Genetic variants of the kynurenine-3-monooxygenase and postpartum depressive symptoms after cesarean section in Chinese womenSaiying Wang, Kaiming Duan, Xiao-Fang Tan, Ji‐Ye Yin, Xiao‐Yuan Mao, Wei Zheng, Chunyan Wang, Mi Yang, Cheng Peng, Hong‐Hao Zhou et al. · 2017 · Journal of Affective Disorders
- Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint StressYoung-Soo Koo, Hyunha Kim, J. Park, Min Jae Kim, Y. Shin, B. Choi, Seo-Yeon Lee, H. Shin · 2018 · Oxidative Medicine and Cellular Longevity
- Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic AcidEdén Flores-Barrera, Daniel R. Thomases, Daryn K. Cass, Ajay Bhandari, Robert M. Schwarcz, John P. Bruno, Kuei Yuan Tseng · 2017 · Journal of Neuroscience
- Picolinic acid modulates kainic acid-evoked glutamate release from the striatum in vitroLynda M. Vrooman, Khem H. Jhamandas, Roland J. Boegman, Richard J Beninger · 1993 · Brain Research
- Coordination Complex Formation and Redox Properties of Kynurenic and Xanthurenic Acid Can Affect Brain Tissue HomeodynamicsLenka Kubicová, Franz Hadaček, Gert Bachmann, Wolfram Weckwerth, Vladimı́r Chobot · 2019 · Antioxidants
- A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological studyIldikó Demeter, Károly Nagy, Levente Gellért, László Vécsei, Ferenc Fülöp, József Toldi · 2012 · Journal of Neural Transmission
- Uptake of 3-hydroxykynurenine measured in rat brain slices and in a neuronal cell lineClifford L. Eastman, Tomás R. Guilarte, John R. Lever · 1992 · Brain Research
- Neuroinflammation and NeurodegenerationInelia Morales, Gonzalo A. Farias, Nicole Cortés, Ricardo Benjamin Maccioni · 2016 · InTech eBooks
- Modification of Kynurenine Pathway via Inhibition of Kynurenine Hydroxylase Attenuates Surgical Brain Injury Complications in a Male Rat ModelG. Zakhary, P. Sherchan, Qian Li, Ji-Ping Tang, John H. Zhang · 2019 · Journal of Neuroscience Research
- Minocycline as adjunctive treatment for treatment-resistant depression: study protocol for a double blind, placebo-controlled, randomized trial (MINDEP2)Muhammad Ishrat Husain, Clare Cullen, Madeha Umer, Andre F. Carvalho, Stefan M. Kloiber, Jeffrey H. Meyer, Abigail Ortiz, Yuliya Knyahnytska, Muhammed Omair Husain, Justine L. Giddens et al. · 2020 · BMC Psychiatry
- Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptorHirohiko Hikichi, Tetsuaki Hiyoshi, Toshiyuki Marumo, Yasumitsu Tomishima, Ayaka Kaku, Izumi Iida, Hiroki Urabe, Tomoko Tamita, Akito Yasuhara, Jun-ichi Karasawa et al. · 2015 · Journal of Pharmacological Sciences
- The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesiaAngelika Richter, Melanie Hamann · 2003 · European Journal of Pharmacology
- Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acidsIzyaslaw P. Lapin · 1983 · Journal of Neural Transmission
- A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson’s DiseaseDolores Vilas, Rubén Fernández‐Santiago, Elena Sanchez, Luis J. Azcona, Meritxell Santos-Montes, Pilar Casquero, Lucía Argandoña, EDUARDO S. TOLOSA, Coro Paisán‐Ruiz · 2017 · Journal of Parkinson s Disease
- Kynurenic Acid Prevents Cytoskeletal Disorganization Induced by Quinolinic Acid in Mixed Cultures of Rat StriatumPaula Pierozan, Helena Biasibetti, Felipe Schmitz, Fernanda Silva Ferreira, Regina Pessoa‐Pureur, Ângela Terezinha de Souza Wyse · 2017 · Molecular Neurobiology
- Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 ExpressionAditya Joshi, Ekram Hossain, Cornelis J. Elferink · 2017 · Molecular Pharmacology
- The IDO genetic polymorphisms and postpartum depressive symptoms: an association study in Chinese parturients who underwent cesarean sectionKaiming Duan, Saiying Wang, Ji‐Ye Yin, Xi Li, Jiahui Ma, Zhendong Huang, Ying Zhou, He‐Ya Yu, Mi Yang, Hong‐Hao Zhou et al. · 2018 · Archives of Women s Mental Health
- Histological and ultrastructural changes in the rat brain following systemic administration of picolinic acidMirosław Beskid, J Jachimowicz, A Taraszewska, D. Kukulska · 1995 · Experimental and Toxicologic Pathology
- Prolonged therapy with antidepressants increases hippocampal level of kynurenic acid and expression of Kat1 and Kat2 genesTomasz Kocki, Ewa M. Urbańska, Janusz Kocki, Renata Kloc, Katarzyna Kocka, Marcin Olajossy, Björn Owe‐Larsson · 2018 · Pharmacological Reports
- Celecoxib augmentation of escitalopram in treatment-resistant bipolar depression and the effects on Quinolinic AcidMonica Feliz R. Castillo, Stephen Murata, Markus Schwarz, Gregor A. Schütze, Natalie Moll, Brendan Martin, Bianca Burger, Elif Weidinger, Norbert Mueller, Angelos E Halaris · 2019 · Neurology Psychiatry and Brain Research
- Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in MiceLee Peyton, Alfredo Oliveros, Maximilian Tufvesson‐Alm, Lilly Schwieler, Phillip A. Starski, Göran Engberg, Sophie Erhardt, Doo‐Sup Choi · 2019 · International Journal of Tryptophan Research
- The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese womenChengxuan Quan, Saiying Wang, Kaiming Duan, Jiahui Ma, He‐Ya Yu, Mi Yang, Na Hu, Ge Long, Guang Zeng, Zhendong Huang · 2020 · Brain and Behavior
- Absence of microglia or presence of peripherally‐derived macrophages does not affect tau pathology in young or old hTau miceKeying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing‐Mei Zhang, Robert Adam Harris, Harald Lund · 2020 · Glia
- Imaging cerebral tryptophan metabolism in brain tumor-associated depressionEdit Bosnyák, David Olayinka. Kamson, Michael E. Behen, Geoffrey R. Barger, Sandeep Mittal, Csaba Juhász · 2015 · EJNMMI Research
- Transport of Xanthurenic Acid by Rat/Human Organic Anion Transporters OAT1 and OAT3Yuichi Uwai, Emi HONJO · 2013 · Bioscience Biotechnology and Biochemistry
- Comparative genotoxicity of 3-hydroxyanthranilic acid and anthranilic acid in the presence of a metal cofactor Cu (II) in vitroGopi S. Gadupudi, King‐Thom Chung · 2011 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIVVanessa Douet, Naomi Tanizaki, Adrian A. Franke, Xingnan Li, Linda Chang · 2016 · Journal of Neuroimmune Pharmacology
- Influence of picolinic acid on seizure susceptibility in miceAnna Cioczek‐Czuczwar, Piotr Czuczwar, Waldemar Andrzej Turski, Jolanta Parada-Turska · 2016 · Pharmacological Reports
- Novel Therapeutic Targets for Major Depressive DisorderMax A. Lazar, Roger S. McIntyre · 2019 · Elsevier eBooks
- Studies of the Association between the Kynurenine-3-Monooxygenase Gene and DepressionТ. В. Лежейко, Вера Евгеньевна Голимбет, A. V. Andryushchenko, A. Melik-Pashayan, E. V. Mironova · 2018 · Neuroscience and Behavioral Physiology
- Cinnabarinic Acid was Formed in Damaged Mitochondria and its Effect on Mitochondrial RespirationYouichi Nagamura, Kentaro Uesugi, J. Naito, Isao Ishiguro · 1999 · Advances in experimental medicine and biology
- Association of kynurenine-3-monooxygenase gene with schizophreniaВера Евгеньевна Голимбет, Т. В. Лежейко, М. В. Алфимова, Lilia I. Abramova, Nikolai Kondratev · 2014 · Russian Journal of Genetics
- Gemst: a taylor-made combination that reverts neuroanatomical changes in strokeArturo Mangas, Javier Yajeya, N. González, I. Ruiz, Marianny Pernía, M. Geffard, Rafael Coveñas · 2017 · European Journal of Histochemistry
- Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled TrialAisen, Paul S., Schafer, Kimberly A., Grundman, Michael, Pfeiffer, Eric, Sano, Mary, Davis, Kenneth L., Farlow, Martin R., Jin, Shelia, Thomas, Ronald G., Thal, Leon J. et al. · 2003 · JAMA
- Inflammatory Abnormalities in Major Depressive DisorderGaurav Singhal, Bernhard T. Baune · 2019 · Elsevier eBooks
- Correction: Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?Johann Steiner, Martin Walter, Tomasz Gos, Gilles J. Guillemin, Hans‐Gert Bernstein, Zóltan Sarnyai, Christian Mawrin, Ralf Brisch, Hendrik Bielau, Louise M zu Schwabedissen et al. · 2013 · Journal of Neuroinflammation
- A67 RAPID REDUCTION IN ANXIETY SCORES IN IBD PATIENTS AFTER INFLIXIMAB INFUSION IS ASSOCIATED WITH CHANGES IN KYNURENINE/TRYPTOPHAN METABOLISMCaroline Seiler, Christian Avila, R Khana, Erika Springer, C. James, David Armstrong, John Kenneth Marshall, Stephen Michael Collins, María Inés Pinto-Sánchez, Premsyl Bercik · 2018 · Journal of the Canadian Association of Gastroenterology