CoChat
Sign Up
Cited by 52Lipid metabolism and biosynthesisLipid metabolism and disordersCancer, Lipids, and Metabolism

Lipid droplets in disease

Open access
Dalhaimer, Paul·2019·Cells
DOI 10.3390/cells8090974PMC PMC6770496
Open this paper in CoChat — free accountOpen PDF

Abstract

Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular disease, and cancer [...]

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/cells8090974

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Excess lipid droplet accumulation is associated with several diseases, including Alzheimer's disease.

    “It is well documented that several diseases are associated with excessive LDs, including but not limited to obesity, atherosclerosis, cancer, type 2 diabetes, and Alzheimer’s disease (AD) (Farmer et al., 2020; Dalhaimer, 2019)”

    From APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses (2025) · cites this paper as Dalhaimer, 2019

    In “Lipid Droplets in Disease” (page unavailable), Dalhaimer links lipid droplets to obesity, type 2 diabetes, Alzheimer’s disease, cardiovascular disease, and cancer. The section also reports increased small lipid droplets in APOE4-expressing astrocytes. It does not establish excessive lipid droplet accumulation across every disease in the citing sentence, particularly atherosclerosis. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 21

  1. [1]Ghosh S. Zhao B. Bie J. Song J. Macrophage cholesterol ester mobilization and atherosclerosis Vasc. Pharmacol. 2010 52 1 10 10.1016/j.vph.2009.10.002 19878739 PMC2823947 · DOI
  2. [2]Harris C.A. Hass J.T. Strepper R.S. Stone S.J. Kumari M. Yang K. Han X. Brownell N. Gross R.W. Zechner R. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes J. Lipid Res. 2011 52 657 667 10.1194/jlr.M013003 21317108 PMC3284159 · DOI
  3. [3]Choudhary V. Golani G. Joshi A.S. Cottier S. Schneiter R. Prinz W.A. Kozlov M.M. Architecture of lipid droplets in endoplasmic reticulum is determined by phospholipid intrinsic curvature Curr. Biol. 2008 28 915 926 10.1016/j.cub.2018.02.020 29526591 PMC5889118 · DOI
  4. [4]Jornayvaz F.R. Shulman G.I. Diacylglycerol activation of protein kinase C epsilon and hepatic insulin resistance Cell Metab. 2012 15 574 584 10.1016/j.cmet.2012.03.005 22560210 PMC3353749 · DOI
  5. [5]Preuss C. Jelenik T. Bodis K. Mussig K. Burkart V. Szendroedi J. Roder M. Markgraf D.F. A new targeted lipidomics approach reveals lipid droplets in liver, muscle and heart as a repository for diacylglycerol and ceramide Cells 2019 8 277 10.3390/cells8030277 30909521 PMC6468791 · DOI
  6. [6]Bobowski-Gerard M. Zummo F.P. Staels B. Lefebvre P. Eeckhoute J. Retinoids issued from hepatic stellate cell lipid droplet loss as potential signaling molecules orchestrating a multicellular liver injury response Cells 2018 7 137 10.3390/cells7090137 30217095 PMC6162435 · DOI
  7. [7]Yang H.L. Galea A. Sytnyk V. Crossley M. Controlling the size of lipid droplets: Lipid and protein factors Curr. Opin. Cell Biol. 2012 24 509 516 10.1016/j.ceb.2012.05.012 22726586 · DOI
  8. [8]Slayton M. Gupta A. Balakrishnan B. Puri V. CIDE proteins in human health and disease Cells 2019 8 238 10.3390/cells8030238 PMC6468517 30871156 · DOI
  9. [9]Brasaemle D.L. Dolios G. Shapiro L. Wang R. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes J. Biol. Chem. 2004 279 46835 46842 10.1074/jbc.M409340200 15337753 · DOI
  10. [10]Granneman J.G. Moore H.P.H. Krishnamoorthy R. Rathod M. Perilipin controls lipolysis by regulating the interaction of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (ATGL) J. Biol. Chem. 2009 284 34538 34544 10.1074/jbc.M109.068478 19850935 PMC2787315 · DOI
  11. [11]Lafontan M. Langin D. Lipolysis and lipid mobilization in human adipose tissue Prog. Lipid Res. 2009 48 275 297 10.1016/j.plipres.2009.05.001 19464318 · DOI
  12. [12]Young S.G. Zechner R. Biochemistry and pathophysiology of intravascular and intracellular lipolysis Genes Dev. 2013 27 459 484 10.1101/gad.209296.112 23475957 PMC3605461 · DOI
  13. [13]Missaglia S. Coleman R.A. Mordente A. Tavian D. Neutral lipid storage diseases as cellular model to study lipid droplet function Cells 2019 8 187 10.3390/cells8020187 PMC6406896 30795549 · DOI
  14. [14]Listenberger L. Townsend E. Rickertsen C. Hains A. Brown E. Inwards E.G. Stoeckman A.K. Matis M.P. Sampathkumar R.S. Osna N.A. Decreasing phosphatidylcholine on the surface of the lipid droplet correlates with altered protein binding and steatosis Cells 2018 7 230 10.3390/cells7120230 PMC6316228 30477200 · DOI
  15. [15]Goodman J.M. The gregarious lipid droplet J. Biol. Chem. 2008 283 28005 28009 10.1074/jbc.R800042200 18611863 PMC2568941 · DOI
  16. [16]Chokchaiwong S. Kuo Y.-T. Hsu S.-P. Hsu Y.-C. Lin S.-H. Zhong W.-B. Lin Y.-F. Kao S.-H. ETF-QO mutants uncoupled fatty acid beta-oxidation and mitochondrial bioenergetics leading to lipid pathology Cells 2019 8 106 10.3390/cells8020106 PMC6406559 30709034 · DOI
  17. [17]Chen Y.-S. Liu H.-M. Lee T.-Y. Ursodeoxycholic acid regulates hepatic energy homeostasis and white adipose tissue macrophages polarization in leptin-deficient obese mice Cells 2019 8 253 10.3390/cells8030253 PMC6468643 30884843 · DOI
  18. [18]Li X. Li Z. Zhao M. Nei Y. Liu P. Zhu Y. Zhang X. Skeletal muscle lipid droplets and the athlete’s paradox Cells 2019 8 249 10.3390/cells8030249 PMC6468652 30875966 · DOI
  19. [19]Berndt N. Eckstein J. Heucke N. Gajowski R. Stockmann M. Meierhofer D. Holzhutter H.-G. Characterization of lipid and lipid droplet metabolism in human HCC Cells 2019 8 512 10.3390/cells8050512 PMC6562484 31137921 · DOI
  20. [20]Liu C.-C. Kanekiyo T. Xu H. Bu G. Apolipoprotein E and Alzheimer disease: Risk, mechanisms, and therapy Nat. Rev. Neurol. 2013 9 106 118 10.1038/nrneurol.2012.263 23296339 PMC3726719 · DOI · Paper page
  21. [22]Libbing C.L. McDevitt A.R. Azcueta R.-M.P. Ahila A. Mulye M. Lipid droplets: A significant but understudied contributor of host-bacterial interactions Cells 2019 8 354 10.3390/cells8040354 PMC6523240 30991653 · DOI

Cited by

Sorted by citations

Authors
Dalhaimer, P.
Affiliations
University of Tennessee at Knoxville (US)
Corresponding author
Dalhaimer, Paul
ORCID
Dalhaimer, Paul
Venue
Cells
Publisher
MDPI AG
Published
2019-08-26
Volume
8
Issue
9
Pages
974
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells8090974
PMC
PMC6770496
OpenAlex
W2969446569
Cited by
52
References
1
Citations by year
2026: 6 · 2025: 10 · 2024: 12 · 2023: 3 · 2022: 9 · 2021: 9 · 2020: 2 · 2018: 1
FWCI
2.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
lipid droplets, fat deposition, lipid metabolism disorders, obesity, hepatic steatosis, type 2 diabetes, Alzheimer's disease, cardiovascular disease, cancer
MeSH terms
Cardiovascular Diseases, Diabetes Mellitus, Type 2, Fatty Liver, Humans, Mitochondria, Neoplasms, Obesity, Lipid Metabolism, Lipid Droplets

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review