MMP14 in sarcoma: a regulator of tumor microenvironment communication in connective tissues
Open accessAbstract
Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell–cell and cell–extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.
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Adverse clinical cancer outcomes are reported to be relevant to sarcopenic obesity, especially with respect to dose-limiting toxicity, surgical complications, physical disability, and shorter survival.
“Moreover, adverse clinical cancer outcomes reported to be relevant to SO, especially with respect to dose-limiting toxicity, surgical complications, physical disability, and shorter survival (59–61).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [61]
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References 199 · Cited by 89
- Authors
- Gonzalez-Molina, J., Gramolelli, S., Liao, Z., Carlson, J. W., Ojala, P. M., & Lehti, K.
- Affiliations
- Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 17177 Stockholm, Sweden
- University of Helsinki (FI)
- Nanyang Technological University (SG)
- Karolinska Institutet (SE)
- Corresponding author
- Lehti, Kaisa
- ORCID
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-08-28
- Volume
- 8
- Issue
- 9
- Pages
- 991
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC6770050
- OpenAlex
- W2970922664
- Cited by
- 89
- References
- 199
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 8 · 2023: 17 · 2022: 12 · 2021: 18 · 2020: 11 · 2019: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Cancerfonden
- Karolinska Institutet
- Vetenskapsrådet
- Sigrid Juséliuksen Säätiö
- Barncancerfonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- MMP-14, membrane-type matrix metalloproteinases, sarcoma, tumor microenvironment, extracellular matrix remodeling, extracellular matrix degradation, cell invasion, metastasis, mesenchymal phenotype, pediatric sarcoma, connective tissue
- MeSH terms
- Adult, Cell Communication, Child, Connective Tissue, Extracellular Matrix, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Sarcoma, Gene Expression Regulation, Neoplastic, Matrix Metalloproteinase 14, Tumor Microenvironment
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