The DOI matches its Crossref record; 177 of the 177 references it cites were found in a registry or an index.
Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy
Open accessAbstract
Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90. HSPs function in diverse physiological and protective processes to assist in maintaining cellular homeostasis. In particular, HSPs participate in protein folding and maturation processes under diverse stressors such as heat shock, hypoxia, and degradation. Notably, HSPs also play essential roles across cancers as they are implicated in a variety of cancer-related activities such as cell proliferation, metastasis, and anti-cancer drug resistance. In this review, we comprehensively discuss the functions of HSPs in association with cancer initiation, progression, and metastasis and anti-cancer therapy resistance. Moreover, the potential utilization of HSPs to enhance the effects of chemo-, radio-, and immunotherapy is explored. Taken together, HSPs have multiple clinical usages as biomarkers for cancer diagnosis and prognosis as well as the potential therapeutic targets for anti-cancer treatment.
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2 retracted
Cordonnier, T., Bishop, J. L., Shiota, M., Nip, K. M., Thaper, D., Vahid, S., Heroux, D., Gleave, M. E., & Zoubeidi, A. (2014) · International Journal of Cancer · doi:10.1002/ijc.29122 · Cited by 71
RetractedFu, W., Wang, W.-M., Wang, H., Zhu, X. M., Liang, Y. Q., Kung, H., & Zhang, J. (2013) · Cell Biology International · doi:10.1002/cbin.10193 · Cited by 12
RetractedBray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Global patterns and trends in colorectal cancer incidence and mortality
Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2017) · Gut · doi:10.1136/gutjnl-2015-310912 · Cited by 5,228
Cancer drug resistance: an evolving paradigm
Holohan, C., Van Schaeybroeck, S., Longley, D. B., & Johnston, P. G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3599 · Cited by 4,681
AKT/PKB Signaling: Navigating the Network
Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772
Hospital-acquired renal insufficiency
Nash, K., Hafeez, A., & Hou, S. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.32766 · Cited by 1,951
Vyas, S., Zaganjor, E., & Haigis, M. C. (2016) · Cell · doi:10.1016/j.cell.2016.07.002 · Cited by 1,735
Melatonin as an antioxidant: under promises but over delivers
Reiter, R. J., Mayo, J. C., Tan, D., Sainz, R. M., Alatorre‐Jimenez, M., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,703
Cited by
Small molecules targeting protein–protein interactions for cancer therapy
Wu, D., Li, Y., Zheng, L., Xiao, H., Ouyang, L., Wang, G., & Sun, Q. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.05.035 · Cited by 71
Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
Parma, B., Ramesh, V., Gollavilli, P. N., Siddiqui, A., Pinna, L., Schwab, A., Marschall, S., Zhang, S., Pilarsky, C., Napoli, F., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02049-8 · Cited by 46
Metadata
- Authors
- Yun, C. W., Kim, H. J., Lim, J. H., & Lee, S. H.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-12-24
- Volume
- 9
- Issue
- 1
- Pages
- 60
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2997805606
- Cited by
- 284
- References
- 177
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yun, C. W., Kim, H. J., Lim, J. H., & Lee, S. H. (2019). Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy. Cells. https://doi.org/10.3390/cells9010060
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
