The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
HSP70 Multi-Functionality in Cancer
Open accessAbstract
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenomenon of cancer “addiction” to HSP70, tightly linking tumor survival and growth to the HSP70 expression. HSP70 operates in different states through its catalytic cycle, suggesting that it can multi-function in malignant cells in any of these states. Clinically, tumor cells intensively release HSP70 in extracellular microenvironment, resulting in diverse outcomes for patient survival. Given its clinical significance, small molecule inhibitors were developed to target different sites of the HSP70 machinery. Furthermore, several HSP70-based immunotherapy approaches were assessed in clinical trials. This review will explore different roles of HSP70 on cancer progression and emphasize the importance of understanding the flexibility of HSP70 nature for future development of anti-cancer therapies.
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1 retracted
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Cited by
Ramundo, V., Zanirato, G., & Aldieri, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212216 · Cited by 46
Single-molecule evidence of Entropic Pulling by Hsp70 chaperones
Rukes, V., Rebeaud, M. E., Perrin, L. W., De Los Rios, P., & Cao, C. (2024) · Nature Communications · doi:10.1038/s41467-024-52674-y · Cited by 24
Metadata
- Authors
- Albakova, Z., Armeev, G. A., Kanevskiy, L. M., Kovalenko, E. I., & Sapozhnikov, A. M.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-03-02
- Volume
- 9
- Issue
- 3
- Pages
- 587
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W3010628223
- Cited by
- 265
- References
- 229
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- gold
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- Albakova, Z., Armeev, G. A., Kanevskiy, L. M., Kovalenko, E. I., & Sapozhnikov, A. M. (2020). HSP70 Multi-Functionality in Cancer. Cells. https://doi.org/10.3390/cells9030587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
