Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing

Naeem, Muhammad, Majeed, Saman, Hoque, Mubasher Zahir, Ahmad, Irshad·2020·Cells
DOI 10.3390/cells9071608

Cited by (461)

Items 401–461 of 461

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  28. Profiling Plant–pathogen Interactions by Integrative Omics Tools Leads to Speed Breeding of CRISPR-edited Disease-tolerant Crops
    Khadija Benamar, Rachid Ezzouggari, Mohammed Taoussi, Rachid Lahlali · 2025 · CABI biotechnology series.
  29. Transgene-free CRISPR-edited Crops for Stress-resilient Agriculture: Technological Advancements and Applications
    Saniya, Sarfraz Ahmad, Maksud Hasan Shah, Mohammad Ghani Raghib, Vikas Belwal, Pankaj Kumar · 2025 · CABI biotechnology series.
  30. Evaluating CRISPR-Cas9's Ability for Identifying the Etiology of Multiple Sclerosis
    Shima Bayat, Seyed Aidin Sajedi · 2025 · Russian Open Medical Journal
  31. CRISPR-Cas opens a new era of antimicrobial therapy as a powerful gene editing tool
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  32. DNA vs. RNA Editing: A Systematic Review Evaluating CRISPR-Cas9 and CRISPR-Cas13 Therapies for Huntington's Disease
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  33. Environmental molecular physiology
    2023 · CSIRO Publishing eBooks
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  35. Optimized guide RNA design and evaluation of CRISPR/Cas9 cleavage efficiency in LEP gene knockout
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  56. Navigating off-target effects in CRISPR-based genome editing for safer gene therapies
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  59. CRISPR‐Cas9 in Cancer Therapy: Overcoming Delivery Barriers and Off‐Target Effects for Clinical Translation
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  61. Ethical and Scientific Concerns Relating to CRISPR/Cas Gene Therapy
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