Gamma Delta T Cells (γδ T Cells) in Health and Disease: In Memory of Professor Wendy Havran
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Gamma delta (γδ) T cells are a small subset of CD3-positive T cells in the peripheral blood but occur at increased frequency in mucosal tissues [...]
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γδ T cells are a small subset of CD3-positive T cells in peripheral blood but occur at increased frequency in mucosal tissues in mice and humans.
“Gamma delta (γδ) T cells are a small subset of CD3-positive T cells in the peripheral blood but occur at increased frequency in mucosal tissues in mice and humans (1).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [1]
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- [1]Saito H. Kranz D.M. Takagaki Y. Hayday A.C. Eisen H.N. Tonegawa S. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes Nature 1984 312 36 40 10.1038/312036a0 6208487 · DOI
- [2]Brenner M.B. McLean J. Dialynas D.P. Strominger J.L. Smith J.A. Owen F.L. Seidman J.G. Ip S. Rosen F. Krangel M.S. Identification of a putative second T-cell receptor Nature 1986 322 145 149 10.1038/322145a0 27183647 · DOI
- [3]Loh E.Y. Lanier L.L. Turck C.W. Littman D.R. Davis M.M. Chien Y.H. Weiss A. Identification and sequence of a fourth human T cell antigen receptor chain Nature 1987 330 569 572 10.1038/330569a0 2825032 · DOI
- [4]Jitsukawa S. Faure F. Lipinski M. Triebel F. Hercend T. A novel subset of human lymphocytes with a T cell receptor-γ complex J. Exp. Med. 1987 166 1192 1197 10.1084/jem.166.4.1192 2443600 PMC2188730 · DOI
- [5]Constant P. Davodeau F. Peyrat M.A. Poquet Y. Puzo G. Bonneville M. Fournié J.J. Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands Science 1994 264 267 270 10.1126/science.8146660 8146660 · DOI
- [6]Kabelitz D. Small molecules for the activation of human gammadelta T cell responses against infection Recent Pat. Antiinfect Drug Discov. 2008 3 1 9 10.2174/157489108783413218 18221182 · DOI
- [7]Gober H.J. Kistowska M. Angman L. Jenö P. Mori L. De Libero G. Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells J. Exp. Med. 2003 197 163 168 10.1084/jem.20021500 12538656 PMC2193814 · DOI
- [8]Harly C. Guillaume Y. Nedellec S. Peigné C.M. Mönkkönen H. Mönkkönen J. Li J. Kuball J. Adams E.J. Netzer S. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset Blood 2012 120 2269 2279 10.1182/blood-2012-05-430470 22767497 PMC3679641 · DOI
- [9]Rigau M. Ostrouska S. Fulford T.S. Johnson D.N. Woods K. Ruan Z. McWilliam H.E.G. Hudson C. Tutuka C. Wheatley A.K. Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells Science 2020 367 6478 10.1126/science.aay5516 31919129 · DOI
- [10]Karunakaran M.M. Willcox C.R. Salim M. Paletta D. Fichtner A.S. Noll A. Starick L. Nöhren A. Begley C.R. Berwick K.A. Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing Immunity 2020 52 487 498 10.1016/j.immuni.2020.02.014 32155411 PMC7083227 · DOI
- [11]Melandri D. Zlatareva I. Chaleil R.A.G. Dart R.J. Chancellor A. Nussbaumer O. Polyakova O. Roberts N.A. Wesch D. Kabelitz D. The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness Nat. Immunol. 2018 19 1352 1365 10.1038/s41590-018-0253-5 30420626 PMC6874498 · DOI
- [12]Kabelitz D. Serrano R. Kouakanou L. Peters C. Kalyan S. Cancer immunotherapy with γδ T cells: Many paths ahead of us Cell Mol. Immunol. 2020 17 925 939 10.1038/s41423-020-0504-x 32699351 PMC7609273 · DOI
- [13]Witherden D.A. Wendy L. Havran, PhD: 1955–2020 Cells 2020 9 1039 10.3390/cells9041039 32331225 PMC7226263 · DOI
- [14]Fonseca S. Pereira V. Lau C. Teixeira M.A. Bini-Antunes M. Lima M. Human Peripheral Blood Gamma Delta T Cells: Report on a Series of Healthy Caucasian Portuguese Adults and Comprehensive Review of the Literature Cells 2020 9 729 10.3390/cells9030729 PMC7140678 32188103 · DOI
- [15]Wesch D. Hinz T. Kabelitz D. Analysis of the TCR Vgamma repertoire in healthy donors and HIV-1-infected individuals Int Immunol. 1998 10 1067 1075 10.1093/intimm/10.8.1067 9723692 · DOI
- [16]Fichtner A.S. Ravens S. Prinz I. Human γδ TCR Repertoires in Health and Disease Cells 2020 9 800 10.3390/cells9040800 32225004 PMC7226320 · DOI
- [17]Xu W. Lau Z.W.X. Fulop T. Larbi A. The Aging of γδ T Cells Cells 2020 9 1181 10.3390/cells9051181 32397491 PMC7290956 · DOI
- [18]Rampoldi F. Ullrich L. Prinz I. Revisiting the Interaction of γδ T-Cells and B-Cells Cells 2020 9 743 10.3390/cells9030743 32197382 PMC7140609 · DOI
- [19]Herrmann T. Fichtner A.S. Karunakaran M.M. An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells Cells 2020 9 1433 10.3390/cells9061433 PMC7348870 32527033 · DOI · Paper page
- [20]Serrano R. Wesch D. Kabelitz D. Activation of Human γδ T Cells: Modulation by Toll-Like Receptor 8 Ligands and Role of Monocytes Cells 2020 9 713 10.3390/cells9030713 PMC7140608 32183240 · DOI
- [21]Havran W.L. Poenie M. Tigelaar R.E. Tsien R.Y. Allison J.P. Phenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones J. Immunol. 1989 142 1422 1428 2783942
- [22]Havran W.L. Chien Y.H. Allison J.P. Recognition of self antigens by skin-derived T cells with invariant gamma delta antigen receptors Science. 1991 252 1430 1432 10.1126/science.1828619 1828619 · DOI
- [23]Witherden D.A. Watanabe M. Garijo O. Rieder S.E. Sarkisyan G. Cronin S.J. Verdino P. Wilson I.A. Kumanogoh A. Kikutani H. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function Immunity. 2012 37 314 325 10.1016/j.immuni.2012.05.026 22902232 PMC3430606 · DOI
- [24]Johnson M.D. Witherden D.A. Havran W.L. The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance Cells 2020 9 686 10.3390/cells9030686 32168884 PMC7140644 · DOI
- [25]Nussbaumer O. Thurnher M. Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance Cells 2020 9 772 10.3390/cells9030772 32235722 PMC7140623 · DOI
- [26]Bank I. The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases Cells 2020 9 462 10.3390/cells9020462 PMC7072729 32085540 · DOI
- [27]Clohosey M.L. Mann B.T. Ryan P.L. Apanasovich T. Maggirwar S.B. Pennington D.J. Soriano-Sarabia N. Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals Cells 2020 9 2568 PMC7760715 33271808
- [28]Girardi M. Oppenheim D.E. Steele C.R. Lewis J.M. Glusac E. Filler R. Hobby P. Sutton B. Tigelaar R.E. Hayday A.C. Regulation of cutaneous malignancy by gammadelta T cells Science 2001 294 605 609 10.1126/science.1063916 11567106 · DOI
- [29]Gentles A.J. Newman A.M. Liu C.L. Bratman S.V. Feng W. Kim D. Nair V.S. Xu Y. Khuong A. Hoang C.D. The prognostic landscape of genes and infiltrating immune cells across human cancers Nat. Med. 2015 21 938 945 10.1038/nm.3909 26193342 PMC4852857 · DOI
- [30]Tosolini M. Pont F. Poupot M. Vergez F. Nicolau-Travers M.L. Vermijlen D. Sarry J.E. Dieli F. Fournié J.J. Assessment of tumor-infiltrating TCRV γ9Vδ2 γδ lymphocyte abundance by deconvolution of human cancers microarrays Oncoimmunology 2017 6 e1284723 10.1080/2162402X.2017.1284723 28405516 PMC5384348 · DOI
- [31]Yoo S.Y. Park H.E. Kim J.H. Wen X. Jeong S. Cho N.Y. Gwon H.G. Kim K. Lee H.S. Jeong S.Y. Whole-Slide Image Analysis Reveals Quantitative Landscape of Tumor-Immune Microenvironment in Colorectal Cancers Clin. Cancer Res. 2020 26 870 881 10.1158/1078-0432.CCR-19-1159 31757879 · DOI
- [32]Chabab G. Boissière-Michot F. Mollevi C. Ramos J. Lopez-Crapez E. Colombo P.-E. Jacot W. Bonnefoy N. Lafont V. Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers Cells 2020 9 1537 10.3390/cells9061537 32599843 PMC7348937 · DOI
- [33]Wang Y. Jia A. Bi Y. Wang Y. Yang Q. Cao Y. Li Y. Liu G. Targeting Myeloid-Derived Suppressor Cells in Cancer Immunotherapy Cancers 2020 12 2626 10.3390/cancers12092626 32942545 PMC7564060 · DOI
- [34]Wesch D. Kabelitz D. Oberg H.H. Tumor resistance mechanisms and their consequences on γδ T cell activation Immunol Rev. 2020 298 84 98 10.1111/imr.12925 33048357 · DOI
- [35]Jonescheit H. Oberg H.-H. Gonnermann D. Hermes M. Sulaj V. Peters C. Kabelitz D. Wesch D. Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells Cells 2020 9 1140 10.3390/cells9051140 32384638 PMC7290398 · DOI
- [36]Kouakanou L. Xu Y. Peters C. He J. Wu Y. Yin Z. Kabelitz D. Vitamin C promotes the proliferation and effector functions of human γδ T cells Cell Mol. Immunol. 2020 17 462 473 10.1038/s41423-019-0247-8 31171862 PMC7192840 · DOI
- [37]Fischer S. Scheffler A. Kabelitz D. Activation of human gamma delta T-cells by heat-treated mistletoe plant extracts Immunol Lett. 1996 52 69 72 10.1016/0165-2478(96)02584-9 8905398 · DOI
- [38]Ma L. Phalke S. Stévigny C. Souard F. Vermijlen D. Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells Cells 2020 9 1560 10.3390/cells9061560 PMC7349316 32604868 · DOI
- [39]Künkele K.-P. Wesch D. Oberg H.-H. Aichinger M. Supper V. Baumann C. Vγ9Vδ2 T Cells: Can We Re-Purpose a Potent Anti-Infection Mechanism for Cancer Therapy? Cells 2020 9 829 10.3390/cells9040829 PMC7226769 32235616 · DOI
- [40]Liu Y. Zhang C. The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy Cells 2020 9 1206 10.3390/cells9051206 PMC7290839 32413966 · DOI
- [41]Yazdanifar M. Barbarito G. Bertaina A. Airoldi I. γδ T Cells: The Ideal Tool for Cancer Immunotherapy Cells 2020 9 1305 10.3390/cells9051305 32456316 PMC7290982 · DOI
- [42]Xu Y. Xiang Z. Alnaggar M. Kouakanou L. Li J. He J. Yang J. Hu Y. Chen Y. Lin L. Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer Cell Mol. Immunol. 2020 Epub ahead of print 10.1038/s41423-020-0515-7 32939032 PMC8027668 · DOI
Cited by
Sorted by citations
Comparing Mouse and Human Tissue-Resident γδ T Cells
Qu, G., Wang, S., Zhou, Z., Jiang, D., Liao, A., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891687 · Cited by 87 · see citing works
- Authors
- Kabelitz, D.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Corresponding author
- Kabelitz, Dieter
- ORCID
- Kabelitz, Dieter
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-11-30
- Volume
- 9
- Issue
- 12
- Pages
- 2564
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC7760329
- OpenAlex
- W3106876990
- Cited by
- 11
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel) (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- γδ T cells, mucosal immunity, T cell subsets, mucosal tissues
- MeSH terms
- Intraepithelial Lymphocytes, HLA Antigens, Humans, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, CD8-Positive T-Lymphocytes
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