Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance

Belisario, Dimas Carolina, Kopecka, Joanna, Pasino, Martina, Akman, Muhlis, De Smaele, Enrico, Donadelli, Massimo, Riganti, Chiara·2020·Cells
DOI 10.3390/cells9122598

Cites (234)

Items 201–230 of 230

  1. Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells
    Joanna Kopecka, Stefania Porto, Sara Lusa, Elena Gazzano, Giuseppina Salzano, Antonio Giordano, Vincenzo Desiderio, Dario Ghigo, Michele Caraglia, Giuseppe De Rosa et al. · 2015 · Oncotarget
  2. Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer
    Iris C. Salaroglio, Elena Gazzano, Ahmad Abdullrahman, Eleonora Mungo, Barbara Castella, Gamal Eldein Fathy Abd-Ellatef, Massimo Massaia, Massimo Donadelli, Menachem Rubinstein, Chiara Riganti et al. · 2018 · Journal of Experimental & Clinical Cancer Research
  3. P-Glycoprotein Senses Its Substrates and the Lateral Membrane Packing Density: Consequences for the Catalytic Cycle
    Päivi Äänismaa, Ewa Gatlik-Landwojtowicz, Anna Seelig · 2008 · Biochemistry
  4. Characterization of glycolysis-related gene expression in malignant melanoma
    A. Koch, Eva Vanessa Ebert, Tatjana Seitz, Peter Dietrich, Mark Berneburg, Anja‐Katrin Bosserhoff, Claus Hellerbrand · 2019 · Pathology - Research and Practice
  5. P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
    Joanna Kopecka, Gregory M. Rankin, Iris C. Salaroglio, Sally‐Ann Poulsen, Chiara Riganti · 2016 · Oncotarget
  6. Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms
    Balaraman Kalyanaraman, Gang Cheng, Micaël Hardy, Olivier Ouari, Adam Sikora, Jacek Zielonka, Michael B. Dwinell · 2017 · Interface Focus
  7. p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer
    Chae Young Han, David A. Patten, Seung Gee Lee, Robin J. Parks, David W. Chan, Mary‐Ellen Harper, Benjamin K. Tsang · 2019 · Molecular Carcinogenesis
  8. PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations
    Zhi Yao, Aleck W.E. Jones, Elisa Fassone, Mary G. Sweeney, Magdalena Lebiedzińska, Jan M. Suski, Mariusz Roman Wieckowski, Nicolas Tajeddine, Iain Parry Hargreaves, Takehiro Yasukawa et al. · 2012 · Oncogene
  9. Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities
    María Cristina Estañ, Eva Calviño, Susana Calvo, Beatriz Guillén‐Guío, Marı́a del Carmen Boyano-Adánez, Elena de Blas, Eduardo Rial, Patricio Aller · 2014 · PLoS ONE
  10. Carbonic Anhydrase XII Inhibitors Overcome P-Glycoprotein–Mediated Resistance to Temozolomide in Glioblastoma
    Iris C. Salaroglio, Prashant Mujumdar, Laura Annovazzi, Joanna Kopecka, Marta Mellai, Davide Schiffer, Sally‐Ann Poulsen, Chiara Riganti · 2018 · Molecular Cancer Therapeutics
  11. Expression and significance of hypoxia-inducible factor-1α and MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2 cells
    Jin Xie, Dawei Li, Xinwei Chen, Fei Wang, Pin Dong · 2013 · Oncology Letters
  12. Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation
    Ajay Kumar, Shiva Kant, Sukh Mahendra Singh · 2013 · Toxicology and Applied Pharmacology
  13. Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
    Micol Maria Rigoni, Chiara Riganti, Candida Vitale, Valentina Griggio, Ivana Campia, Marta Robino, Myriam Foglietta, Barbara Castella, Patrizia Sciancalepore, Ilaria Buondonno et al. · 2015 · Oncotarget
  14. Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells
    Elena Gazzano, Loretta Lazzarato, Barbara Rolando, Joanna Kopecka, Stefano Guglielmo, Costanzo Costamagna, Konstantin Yu. Chegaev, Chiara Riganti · 2018 · Frontiers in Pharmacology
  15. 2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells
    Shuo Wang, Yau-Huei Wei, D. Shieh, Li-Ling Lin, Shih-Ping Cheng, Pei-Wen Wang, J. Chuang · 2015 · PLoS ONE
  16. Zoledronic Acid Overcomes Chemoresistance and Immunosuppression of Malignant Mesothelioma
    Salaroglio, Iris Chiara, Campia, Ivana, Kopecka, Joanna, Gazzano, Elena, Orecchia, Sara, Ghigo, Dario, Riganti, Chiara · 2015 · Oncotarget
  17. Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation
    Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae Jung Kim, Seong‐Beom Lee, Sug Hyung Lee, Jong Y. Park et al. · 2019 · BMC Cancer
  18. Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma
    Prashant Mujumdar, Joanna Kopecka, Silvia Bua, Claudiu Trandafir Supuran, Chiara Riganti, Sally‐Ann Poulsen · 2019 · Journal of Medicinal Chemistry
  19. Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma
    Nilay S. Sethi, Osamu Kikuchi, James M. McFarland, Yanxi Zhang, Max Chung, Nicholas Kafker, Mirazul Islam, Benjamin L. Lampson, Abhishek A. Chakraborty, William G. Kaelin et al. · 2019 · JCI Insight
  20. The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction
    Giulia Cheloni, Martina Poteti, Silvia Bono, Erico Masala, Nathalie M. Mazure, Elisabetta Rovida, Matteo Lulli, Persio Dello Sbarba · 2017 · Stem Cells International
  21. Sugar, fat, and protein: new insights into what T cells crave
    Greg M. Delgoffe, Jonathan D. Powell · 2015 · Current Opinion in Immunology
  22. The anti-androgen drug dutasteride renders triple negative breast cancer cells more sensitive to chemotherapy via inhibition of HIF-1α-/VEGF-signaling
    Marie‐Kristin von Wahlde, Carolin Hülsewig, Christian Ruckert, Martin Götte, Ludwig Kiesel, Christof Bernemann · 2014 · Gynecological Endocrinology
  23. Effect of environmental factors on chemoresistance of HepG2 cells by regulating hypoxia-inducible factor-1α.
    Hong Zhu, Shun-Feng Luo, Ji Wang, Xin Li, Hui Wang, Wangyang Pu, Hong Zhang, Zhixiang Zhuang · 2012 · PubMed
  24. Role of Oxygen and Nitrogen Radicals in the Mechanism of Anticancer Drug Cytotoxicity.
    Birandra Kumar Sinha · 2020 · PubMed
  25. Effects of desflurane and isoflurane on intestinal tissue oxygen pressure during colorectal surgery
    M. Müller, Ehrenfried Schindler, Sabine Roth, A. Schürholz, M. Vollerthun, G. Hempelmann · 2002 · Anaesthesia
  26. Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?
    Joanna Kopecka, Elena Gazzano, Barbara Castella, Iris C. Salaroglio, Eleonora Mungo, Massimo Massaia, Chiara Riganti · 2019 · Seminars in Cell and Developmental Biology
  27. Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells
    Josep María Cornet-Masana, Daniel Moreno-Martínez, María Carmen Lara-Castillo, Meritxell Nomdedéu, Amaia Etxabe, Niccoló Tesi, Marta Pratcorona, Jordi Esteve, Ruth M. Risueño · 2016 · Oncotarget
  28. Cobalt Chloride Induces Expression and Function of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Renal Proximal Tubular Epithelial Cell Line HK-2
    Nishihashi Katsuki, Kawashima Kei, Takami Nomura, Yumiko Urakami-Takebayashi, Makoto Miyazaki, Mikihisa Takano, Junya Nagai · 2016 · Biological and Pharmaceutical Bulletin
  29. Pyruvate Treatment Restores the Effectiveness of Chemotherapeutic Agents in Human Colon Adenocarcinoma and Pleural Mesothelioma Cells
    Eleonora Mungo, Loredana Bergandi, Iris C. Salaroglio, Sophie Doublier · 2018 · International Journal of Molecular Sciences
  30. [Hypoxia-inducible factor-1 alpha dependent expression and significance of the related multidrug resistance genes induced by hypoxia in human hepatocarcinoma cell].
    Hong Zhu, Xiaoping Chen, Shun-Feng Luo, Jian Guan, Wanguang Zhang, Bixiang Zhang, Haiping Wang · 2005 · PubMed