The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management
Open accessAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. The relationship of MIS-C to SARS-CoV-2 infection suggests that the pathogenesis involves post-infectious immune dysregulation. Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. Specific immunomodulatory therapy depends on the clinical presentation. The relationship between the immune response to SARS-CoV-2 vaccines in development and MIS-C requires further study.
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Hyperinflammatory shock in children during COVID-19 pandemic
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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
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Cited by
Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., Cook, J. R., Nordvig, A. S., Shalev, D., Sehrawat, T. S., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01283-z · Cited by 4,862
Costagliola, G., Spada, E., & Consolini, R. (2021) · Immunity, Inflammation and Disease · doi:10.1002/iid3.404 · Cited by 81
Metadata
- Authors
- Nakra, N., Blumberg, D., Herrera-Guerra, A., & Lakshminrusimha, S.
- Venue
- Children
- Publisher
- MDPI AG
- Published
- 2020-07-01
- Volume
- 7
- Issue
- 7
- Pages
- 69
- ISSN
- 2227-9067 (ISSN-L)
- OpenAlex
- W3040117178
- Cited by
- 512
- References
- 42
- FWCI
- 89.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management. https://app.cochat.ai/papers/10.3390/children7070069
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- Nakra, N., Blumberg, D., Herrera-Guerra, A., & Lakshminrusimha, S. (2020). Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management. Children. https://doi.org/10.3390/children7070069
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
