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Cited by 26Liver Disease and TransplantationDrug-Induced Hepatotoxicity and ProtectionPediatric Hepatobiliary Diseases and Treatments

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Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania

Open access
Grama, Alina, Aldea, Cornel Olimpiu, Burac, Lucia, Delean, Dan, Bulata, Bogdan, Sirbe, Claudia, Duca, Emanuela, Boghitoiu, Dora, Coroleuca, Alexandra, Pop, Tudor Lucian·2020·Children
DOI 10.3390/children7120282PMC PMC7763257
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Abstract

Background: Acute liver failure (ALF) is a rare disease, associated with high mortality, despite optimal medical therapy without emergency liver transplantation. Knowing the possible cause of ALF plays a vital role in the management, as the child could benefit from effective specific therapies in emergencies. Methods: We have analyzed the etiology and outcome of ALF in children followed-up in a tertiary care hospital between January 2012–December 2018. The patients were grouped into different age categories: neonates (0–1 month), infants (1–12 months), children (1–14 years), and teenagers (14–18 years). Results: 97 children (46 males, 47.42%, the mean age of 7.66 ± 8.18 years) were admitted with ALF. The most important causes of ALF were in neonates and infants, infections (72.72%), and metabolic disorders (43.47%), in children and adolescents were the toxic causes (60% and 79.41%). The mortality rate was 31.95% (31 patients), mainly in ALF due to infections or metabolic disorders. Conclusions: In neonates and infants, the main causes of ALF were infections and metabolic diseases, while in older children and teenagers, were toxin-induced liver injuries. The mortality among neonates and infants was significantly higher than in other ages. Early recognition and immediate therapeutic intervention could improve the outcome of these patients.

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Research works printed but not linked: 27

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Metadata

Authors
Grama, A., Aldea, C. O., Burac, L., Delean, D., Bulata, B., Sirbe, C., Duca, E., Boghitoiu, D., Coroleuca, A., & Pop, T. L.
Affiliations
  • Carol Davila University of Medicine and Pharmacy (RO)
  • Spitalul Clinic de Urgență pentru Copii Cluj-Napoca (RO)
  • Iuliu Hațieganu University of Medicine and Pharmacy (RO)
  • Pediatric Nephrology, Dialysis and Toxicology Clinic, Emergency Clinic Hospital for Children, 400177 Cluj-Napoca, Romania
  • 2nd Pediatric Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400012 Cluj-Napoca, Romania
  • University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania
Corresponding author
Pop, Tudor Lucian
ORCID
Venue
Children
Publisher
MDPI AG
Published
2020-12-09
Volume
7
Issue
12
Pages
282
ISSN
2227-9067 (ISSN-L)
DOI
10.3390/children7120282
PMC
PMC7763257
OpenAlex
W3112520965
Cited by
26
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 1
FWCI
2.65
Type
journal article
Language
en
Open access
Licence
Locations
  • Children (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
Keywords
acute liver failure, pediatric patients, etiology, mortality, neonates, infants, infection, metabolic disorders, toxin-induced liver injury, age differences, outcomes

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CoChat. (2026). Citation check: Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania. https://app.cochat.ai/papers/10.3390/children7120282
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Grama, A., Aldea, C. O., Burac, L., Delean, D., Bulata, B., Sirbe, C., Duca, E., Boghitoiu, D., Coroleuca, A., & Pop, T. L. (2020). Etiology and Outcome of Acute Liver Failure in Children—The Experience of a Single Tertiary Care Hospital from Romania. Children. https://doi.org/10.3390/children7120282

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