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Cited by 17Cervical Cancer and HPV ResearchPreterm Birth and ChorioamnionitisReproductive tract infections research

Maternal HPV Infection and the Estimated Risks for Adverse Pregnancy Outcomes—A Systematic Review

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Popescu, Simona Daniela, Boiangiu, Andreea Gratiana, Sima, Romina-Marina, Bilteanu, Liviu, Vladareanu, Simona, Vladareanu, Radu·2022·Diagnostics
DOI 10.3390/diagnostics12061471PMC PMC9221727
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Abstract

Background: Human Papilloma Virus (HPV) represents the most prevalent genital infection in young women of reproductive age. Objective: This systematic review aims to estimate the effect of HPV infection during pregnancy and assess the correlation between HPV and adverse pregnancy outcomes. Materials and methods: The search strategy has been developed based on the PICOS framework: Population (pregnant women infected with HPV), Intervention (HPV infection confirmed by molecular tests), Comparator (pregnant women without HPV infection), Outcomes (adverse pregnancy outcomes) and Study design (observational studies). We searched PubMed, Web of Science, and Scopus databases on 8 January 2022 by using the following keywords: “HPV”, “prematurity”, “preterm birth”, “miscarriage”, “premature rupture of membranes”, “adverse pregnancy outcome”, “low birth weight”, “fetal growth restriction”, “pregnancy-induced hypertensive disorders”, “preeclampsia”. Selection criteria were HPV infection confirmed within maximum 2 years before pregnancy with a molecular test and adverse pregnancy outcomes. (Results: Although numerous studies are conducted on this topic, data are still controversial regarding identifying maternal HPV infection as a risk factor for adverse pregnancy outcomes. More prospective large cohort studies are needed to prove a causative relationship.

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  • The association between HPV infection and spontaneous abortions has rarely been investigated, with existing studies limited by small sample sizes and showing conflicting results.

    “The association between HPV infection and spontaneous abortions has rarely been investigated in the literature to date, with existing studies being limited by small sample sizes and showing conflicting results [29, 30].”

    From Fertility and Miscarriage Incidence After Cervical Intraepithelial Neoplasia Treatment by Thermal Ablation: A Cohort Study (2025) · cites this paper as [29]

    The Results (§3.2.1, Miscarriage) say the published data are contradictory and limited by small sample size, supporting the claim about conflicting findings and study limitations. The review identifies nine studies investigating the link and says many studies have examined HPV as a possible miscarriage risk factor; it does not establish that the association has rarely been investigated. (LLM, conf=0.83)

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Authors
Popescu, S. D., Boiangiu, A. G., Sima, R.-M., Bilteanu, L., Vladareanu, S., & Vladareanu, R.
Affiliations
  • Carol Davila University of Medicine and Pharmacy (RO)
  • Department of Preclinic Sciences, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 050097 Bucharest, Romania
  • Neonatology Clinic, Department of Obstetrics and Gynecology, Faculty of General Medicine, Elias University Hospital, Carol Davila University of Medicine and Pharmacy, 011461 Bucharest, Romania
  • Obstetrics and Gynecology Clinic, Department of Obstetrics and Gynecology, Faculty of General Medicine, Elias University Hospital, Carol Davila University of Medicine and Pharmacy, 011461 Bucharest, Romania
Corresponding author
Boiangiu, Andreea Gratiana
ORCID
Venue
Diagnostics
Publisher
MDPI AG
Published
2022-06-15
Volume
12
Issue
6
Pages
1471
ISSN
2075-4418 (ISSN-L)
DOI
10.3390/diagnostics12061471
PMC
PMC9221727
OpenAlex
W4282959395
Cited by
17
References
0
Citations by year
2026: 5 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2
FWCI
0.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Diagnostics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
human papillomavirus, adverse pregnancy outcomes, preterm birth, miscarriage, premature rupture of membranes, low birth weight, fetal growth restriction, preeclampsia, gestational hypertension, risk factors

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