Comparative Genomics and Adaptive Evolution of Bifidobacterium adolescentis in Geographically Distinct Human Gut Populations
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Bifidobacterium adolescentis is prevalent in the gastrointestinal tract of healthy humans, and significantly influences host health. Recent studies have predominantly investigated the probiotic characteristics of individual strains and their specific metabolic roles, whereas analyses at the population genome level have been limited to date. This study conducted a comparative genomics analysis of 543 B. adolescentis genomes to explore genetic background variations and functional gene differences across geographically diverse populations. The results revealed significant differences in genome size and GC content among populations from Asia, Europe, and North America (p < 0.05). The pan-gene exhibited an open structure, reflecting the substantial genetic diversity within B. adolescentis. Functional annotation demonstrated that B. adolescentis possesses numerous protein-coding genes and abundant carbohydrate-active enzymes (CAZys) implicated in carbohydrate degradation and transformation. Population-specific CAZys were identified, suggesting adaptive evolution driven by distinct regional dietary patterns.
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Similar patterns, in which non-Westernized or rural cohorts exhibit greater strain-level and accessory genome diversity than Westernized populations, have been reported within the genus Bifidobacterium.
“Similar patterns, in which non-Westernized or rural cohorts exhibit greater strain-level and accessory genome diversity than Westernized populations, have been reported within the genus Bifidobacterium [34,76] .”
From Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum (2026) · cites this paper as [76]
Results §3.3 (page unavailable) reports an open pan-genome and significantly greater pan-genome expansion in Asian than North American B. adolescentis isolates, supporting a regional difference in genomic diversity. It does not classify the cohorts as rural, non-Westernized, or Westernized, or establish that either category has greater strain-level and accessory-genome diversity overall; North American isolates had the most pan genes in the datasets compared. (LLM, conf=0.85)
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References 45 · Cited by 3
- Authors
- Fu, P., Qi, H., & Liu, W.
- Affiliations
- Inner Mongolia Agricultural University (CN)
- Corresponding author
- Liu, Wenjun
- ORCID
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2025-08-06
- Volume
- 14
- Issue
- 15
- Pages
- 2747
- ISSN
- 2304-8158 (ISSN-L)
- PMC
- PMC12345859
- OpenAlex
- W4413021648
- Cited by
- 3
- References
- 45
- Citations by year
- 2026: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Foods (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Joint Funds of the National Natural Science Foundation of China (U23A20260, NYT22042)
- Youth Science and Technology Talent Project of Higher Education Institutions in Inner Mongolia Autonomous Region (U23A20260, NYT22042)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- Bifidobacterium adolescentis, gut microbiota, population genomics, adaptive evolution, carbohydrate-active enzymes, genome size variation, GC content, pan-genome, dietary adaptation, probiotics
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