Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action
Open accessAbstract
In the middle of the coronavirus disease 19 (COVID-19) outbreak, the main efforts of the scientific community are rightly all focused on identifying efficient pharmacological treatments to cure the acute severe symptoms and developing a reliable vaccine. On the other hand, we cannot exclude that, in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) positive subjects, the virus infection could have long-term consequences, leading to chronic medical conditions such as dementia and neurodegenerative disease. Considering the age of SARS-CoV-2 infected subjects, the neuroinvasive potential might lead/contribute to the development of neurodegenerative diseases. Here, we analyzed a possible link between SARS-CoV-2 infection and Alzheimer’s disease risk, hypothesizing possible mechanisms at the base of disease development. This reflection raises the need to start to experimentally investigating today the mechanistic link between Alzheimer’s disease (AD) and COVID-19 to be ready tomorrow.
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SARS-CoV-2 infection might increase Alzheimer's disease risk through different mechanisms, which could be extrapolated to other cognitive diseases.
“Abate et al. [18] reviewed the different mechanisms by which SARS-CoV-2 infection might increase Alzheimer’s disease (AD) risk, which could be extrapolated to other cognitive diseases.”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [18]
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References 87 · Cited by 56
- Authors
- Abate, G., Memo, M., & Uberti, D.
- Affiliations
- University of Brescia (IT)
- Corresponding author
- Abate, Giulia
- Venue
- Healthcare
- Publisher
- MDPI AG
- Published
- 2020-08-21
- Volume
- 8
- Issue
- 3
- Pages
- 286
- ISSN
- 2227-9032 (ISSN-L)
- PMC
- PMC7551579
- OpenAlex
- W3081184819
- Cited by
- 56
- References
- 87
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 4
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Healthcare (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, public-domain)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (University intramural funding grant to D. Uberti.)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, SARS-CoV-2, Alzheimer's disease, dementia risk, neurodegenerative diseases, neuroinvasion, disease mechanisms
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