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Cited by 10Osteoarthritis Treatment and MechanismsCollagen: Extraction and CharacterizationMusculoskeletal pain and rehabilitation

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Impact of Specific Bioactive Collagen Peptides on Joint Discomforts in the Lower Extremity during Daily Activities: A Randomized Controlled Trial

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Schulze, Claas, Schunck, Michael, Zdzieblik, Denise, Oesser, Steffen·2024·International Journal of Environmental Research and Public Health
DOI 10.3390/ijerph21060687PMC PMC11203623
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Abstract

The intake of specific collagen peptides (SCPs) has been shown to decrease activity-related knee pain in young, physically active adults. This trial investigated the effect of a 12-week SCP supplementation in a wider age range of healthy men and women over 18 years with functional knee and hip pain during daily activities. A total of 182 participants were randomly assigned to receive either 5 g of specific collagen peptides (CP-G) or a placebo (P-G). Pain at rest and during various daily activities were assessed at baseline and after 12 weeks by a physician and participants using a 10-point numeric rating scale (NRS). The intake of 5 g SCP over 12 weeks significantly reduced pain at rest (p = 0.018) and during walking (p = 0.032) according to the physician’s evaluation. Participants in the CP-G also reported significantly less pain when climbing stairs (p = 0.040) and when kneeling down (p < 0.001) compared to the P-G. Additionally, after 12 weeks, restrictions when squatting were significantly lower in the CP-G compared with the P-G (p = 0.014). The daily intake of 5 g of SCP seems to benefit healthy adults with hip and knee joint discomforts by reducing pain during daily activities.

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Metadata

Authors
Schulze, C., Schunck, M., Zdzieblik, D., & Oesser, S.
Affiliations
  • Practice of Surgery Bad Schwartau, Am Kurpark 1, 23611 Bad Schwartau, Germany
  • Clinical Research Center Kiel (DE)
Corresponding author
Zdzieblik, Denise
ORCID
Zdzieblik, Denise
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2024-05-27
Volume
21
Issue
6
Pages
687
ISSN
1660-4601 (ISSN-L)
DOI
10.3390/ijerph21060687
PMC
PMC11203623
OpenAlex
W4399092124
Cited by
10
References
2
Citations by year
2026: 4 · 2025: 6
FWCI
3.24
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
GELITA GmbH
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
collagen supplementation, knee pain, hip pain, joint discomfort, daily activities, walking pain, stair climbing, squatting, kneeling, healthy adults
MeSH terms
Activities of Daily Living, Adult, Aged, Collagen, Double-Blind Method, Female, Hip Joint, Humans, Knee Joint, Male, Middle Aged, Peptides, Dietary Supplements, Lower Extremity, Young Adult

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